ID   LCD1_CANGA              Reviewed;         667 AA.
AC   Q6FNX0;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=DNA damage checkpoint protein LCD1;
GN   Name=LCD1; OrderedLocusNames=CAGL0J08393g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Forms a complex with the serine/threonine kinase MEC1 which
CC       activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1
CC       complex is recruited to DNA lesions in order to initiates the DNA
CC       repair by homologous recombination. Required for cell growth and
CC       meiotic recombination (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with MEC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; CR380956; CAG61025.1; -; Genomic_DNA.
DR   RefSeq; XP_448074.1; XM_448074.1.
DR   AlphaFoldDB; Q6FNX0; -.
DR   SMR; Q6FNX0; -.
DR   STRING; 5478.XP_448074.1; -.
DR   PRIDE; Q6FNX0; -.
DR   EnsemblFungi; CAG61025; CAG61025; CAGL0J08393g.
DR   GeneID; 2889706; -.
DR   KEGG; cgr:CAGL0J08393g; -.
DR   eggNOG; ENOG502QQI0; Eukaryota.
DR   HOGENOM; CLU_383646_0_0_1; -.
DR   InParanoid; Q6FNX0; -.
DR   OMA; IFQYELI; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0070310; C:ATR-ATRIP complex; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0045184; P:establishment of protein localization; IEA:EnsemblFungi.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   InterPro; IPR018622; DNA_damage_chkpnt_Lcd1.
DR   Pfam; PF09798; LCD1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; Cytoplasm; DNA damage; DNA repair;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..667
FT                   /note="DNA damage checkpoint protein LCD1"
FT                   /id="PRO_0000227713"
FT   COILED          28..55
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   667 AA;  77821 MW;  073C015EA204981D CRC64;
     MLRDKLKLLQ AQIEQERSKS NYRVNEVKEE FDKEIQKLRQ QLQSLEDEKK FLVLESRGIN
     AVNQRIKTSP PEAFSRVSSQ HRALNTPDSS HIQEHIPKKR KTEISTQPSI VLNPNRVIKD
     EVSAFFDCLY VHRIVGVELS TIEILNCIKF EHIDEFNYKL LKINKDTSIG SGIVDFLQSC
     KKNMKLNELV DSVLEHLATL IKAIIINDQE LNFSVPFLVA LMVQTILFRP SAVSVNSLKD
     LFIFTCDLIR KFQIVLKKPL HKSPLEVDLG PQIFQYELID NLILVYSFDL LESTTKVIRI
     QQLSETLYME FFDESLMKSL EAVYKLTLTI SFKPVINVIY SMVAVFVTIT NIMNNDNLSK
     PFGSSKWWSD LLTRLYQLLG KRILNFHVFD DTNTNNMHID RFFDFYSLLR NMGTNSVSPL
     LAQLVTRGEI KGIPNIVLKD DIIDKYESKK EKGVLSDNLE LEKWFVYLKD DILSIIENLM
     GYFKKDSKIT NGEILINLTK LISVEQSQFM DHLIDQDTDV FAVRMNLVEH ALSIIYRMWK
     YYEENITQES IKEVESELVM SLWRIIVCKH ASKKICKDDL MEHRILINQM ENLHLQDTID
     LYEDAFEDMP EYIKEELECS INNGTQQKMQ VQYDDIYIEM ARYILESKLT NFISVENTDS
     LYLSMGF