LCDH_NOCDD
ID LCDH_NOCDD Reviewed; 329 AA.
AC D7B2S5;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=L-carnitine dehydrogenase {ECO:0000255|HAMAP-Rule:MF_02129};
DE Short=CDH {ECO:0000255|HAMAP-Rule:MF_02129};
DE Short=L-CDH {ECO:0000255|HAMAP-Rule:MF_02129};
DE EC=1.1.1.108 {ECO:0000255|HAMAP-Rule:MF_02129};
GN Name=lcdH {ECO:0000255|HAMAP-Rule:MF_02129}; OrderedLocusNames=Ndas_1341;
OS Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM
OS 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)
OS (Actinomadura dassonvillei).
OC Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC Nocardiopsis.
OX NCBI_TaxID=446468;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC
RC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509;
RX PubMed=21304737; DOI=10.4056/sigs.1363462;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sun H., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H., Cheng J.F.,
RA Tapia R., Han C., Goodwin L., Pitluck S., Pagani I., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Djao O.D., Rohde M., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU
RT 509).";
RL Stand. Genomic Sci. 3:325-336(2010).
CC -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-
CC dehydrocarnitine. {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH;
CC Xref=Rhea:RHEA:19265, ChEBI:CHEBI:15378, ChEBI:CHEBI:17126,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57885, ChEBI:CHEBI:57945;
CC EC=1.1.1.108; Evidence={ECO:0000255|HAMAP-Rule:MF_02129};
CC -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-
CC carnitine dehydrogenase subfamily. {ECO:0000255|HAMAP-Rule:MF_02129}.
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DR EMBL; CP002040; ADH66773.1; -; Genomic_DNA.
DR RefSeq; WP_013152380.1; NC_014210.1.
DR AlphaFoldDB; D7B2S5; -.
DR SMR; D7B2S5; -.
DR STRING; 446468.Ndas_1341; -.
DR EnsemblBacteria; ADH66773; ADH66773; Ndas_1341.
DR KEGG; nda:Ndas_1341; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_0_1_11; -.
DR OMA; VIGMGWA; -.
DR OrthoDB; 862072at2; -.
DR UniPathway; UPA00117; -.
DR Proteomes; UP000002219; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0047728; F:carnitine 3-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0042413; P:carnitine catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.1040.10; -; 1.
DR HAMAP; MF_02129; L_carnitine_dehydrog; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR026578; L-carnitine_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..329
FT /note="L-carnitine dehydrogenase"
FT /id="PRO_0000417899"
FT BINDING 19..24
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02129"
SQ SEQUENCE 329 AA; 35126 MW; 0D59DB5A3E2D5EA8 CRC64;
MTENARTTPE AVRTVACVGA GVIGGGWVAH FLGRGYRVVA WDPAPDAESR LRGLVSSAWP
ALEELGPAEG ASMANLRVVD TLAEAVADAD FVQESAPERL DLKIDLLAEI DAATPEGVVI
ASSTSGYSMS EMQVGARTPG RLVVGHPFNP PYLVPLVEVV GGERSERWAV DWASDFYRAA
GKSVITMERE LPGFIGNRIQ EAAWREALHM VAEGEATVEQ IDLAMTSGPG LRWAFFGPCL
TFHLAGGEGG MAHMLDHFGP SLKSPWTRLE APELTAGLRD RMVAGTDEVV AGRSTAELIA
QRDRRLIAVA RALEEVERAE AAERAGADA
