LCDH_OCEIH
ID LCDH_OCEIH Reviewed; 307 AA.
AC Q8CUW0;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=L-carnitine dehydrogenase {ECO:0000255|HAMAP-Rule:MF_02129};
DE Short=CDH {ECO:0000255|HAMAP-Rule:MF_02129};
DE Short=L-CDH {ECO:0000255|HAMAP-Rule:MF_02129};
DE EC=1.1.1.108 {ECO:0000255|HAMAP-Rule:MF_02129};
GN Name=lcdH {ECO:0000255|HAMAP-Rule:MF_02129}; OrderedLocusNames=OB0997;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-
CC dehydrocarnitine. {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH;
CC Xref=Rhea:RHEA:19265, ChEBI:CHEBI:15378, ChEBI:CHEBI:17126,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57885, ChEBI:CHEBI:57945;
CC EC=1.1.1.108; Evidence={ECO:0000255|HAMAP-Rule:MF_02129};
CC -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02129}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-
CC carnitine dehydrogenase subfamily. {ECO:0000255|HAMAP-Rule:MF_02129}.
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DR EMBL; BA000028; BAC12953.1; -; Genomic_DNA.
DR RefSeq; WP_011065400.1; NC_004193.1.
DR AlphaFoldDB; Q8CUW0; -.
DR SMR; Q8CUW0; -.
DR STRING; 221109.22776678; -.
DR EnsemblBacteria; BAC12953; BAC12953; BAC12953.
DR KEGG; oih:OB0997; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_0_1_9; -.
DR OMA; RDNCLTH; -.
DR OrthoDB; 862072at2; -.
DR PhylomeDB; Q8CUW0; -.
DR UniPathway; UPA00117; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0047728; F:carnitine 3-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0042413; P:carnitine catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.1040.10; -; 1.
DR HAMAP; MF_02129; L_carnitine_dehydrog; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR026578; L-carnitine_dehydrogenase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..307
FT /note="L-carnitine dehydrogenase"
FT /id="PRO_0000417900"
FT BINDING 8..13
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02129"
SQ SEQUENCE 307 AA; 34183 MW; E4B6186EB33E3A0B CRC64;
MKKVAVIGTG VIGNGWITRF LANGCEVVAH DPAPGAKERT IQAIENAWES VEQLGLKEGA
SKDSLTFVDS IEEAVKDADL IQESVPERYE LKHGVLKEID RFAHSNTIIG SSTSGIKPTD
LQIGLNHPER LVVAHPFNPV YLLPLVEIVG GEATTKEITN RASVYYESLQ MKPMVIEKEI
EGFVADRLME ALWREALHLV NDGIATTEEV DKAITYGAGL RWAQMGPFMT FHLAGGNAGM
RHMLEQFGPA LKLPWTKLEA PELTDELKER VIQGCETHAN DRSVEELEKK RNEFLVKLID
LVEDYWP
