LCE1A_HUMAN
ID LCE1A_HUMAN Reviewed; 110 AA.
AC Q5T7P2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Late cornified envelope protein 1A;
DE AltName: Full=Late envelope protein 1;
GN Name=LCE1A; Synonyms=LEP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5T7P2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11962058, EBI-10173507;
CC Q5T7P2; P29972: AQP1; NbExp=3; IntAct=EBI-11962058, EBI-745213;
CC Q5T7P2; P48745: CCN3; NbExp=3; IntAct=EBI-11962058, EBI-3904822;
CC Q5T7P2; P27918: CFP; NbExp=3; IntAct=EBI-11962058, EBI-9038570;
CC Q5T7P2; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11962058, EBI-741528;
CC Q5T7P2; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-11962058, EBI-3867333;
CC Q5T7P2; O95967: EFEMP2; NbExp=3; IntAct=EBI-11962058, EBI-743414;
CC Q5T7P2; P23142-4: FBLN1; NbExp=3; IntAct=EBI-11962058, EBI-11956479;
CC Q5T7P2; Q9BTY2: FUCA2; NbExp=3; IntAct=EBI-11962058, EBI-9050116;
CC Q5T7P2; P28799: GRN; NbExp=3; IntAct=EBI-11962058, EBI-747754;
CC Q5T7P2; P49639: HOXA1; NbExp=6; IntAct=EBI-11962058, EBI-740785;
CC Q5T7P2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11962058, EBI-11959885;
CC Q5T7P2; Q8IUG1: KRTAP1-3; NbExp=5; IntAct=EBI-11962058, EBI-11749135;
CC Q5T7P2; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11962058, EBI-10172290;
CC Q5T7P2; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-11962058, EBI-10171774;
CC Q5T7P2; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11962058, EBI-10172052;
CC Q5T7P2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11962058, EBI-1052037;
CC Q5T7P2; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11962058, EBI-10210845;
CC Q5T7P2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11962058, EBI-10176379;
CC Q5T7P2; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-11962058, EBI-11953334;
CC Q5T7P2; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-11962058, EBI-10176396;
CC Q5T7P2; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-11962058, EBI-18395721;
CC Q5T7P2; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-11962058, EBI-751260;
CC Q5T7P2; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11962058, EBI-10302392;
CC Q5T7P2; Q9BQ66: KRTAP4-12; NbExp=7; IntAct=EBI-11962058, EBI-739863;
CC Q5T7P2; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11962058, EBI-10172511;
CC Q5T7P2; Q9BYR3: KRTAP4-4; NbExp=6; IntAct=EBI-11962058, EBI-11958132;
CC Q5T7P2; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11962058, EBI-11993254;
CC Q5T7P2; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11962058, EBI-11993296;
CC Q5T7P2; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11962058, EBI-11958178;
CC Q5T7P2; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11962058, EBI-11974251;
CC Q5T7P2; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11962058, EBI-10250562;
CC Q5T7P2; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11962058, EBI-11987425;
CC Q5T7P2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11962058, EBI-3958099;
CC Q5T7P2; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11962058, EBI-1044640;
CC Q5T7P2; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-11962058, EBI-1043191;
CC Q5T7P2; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-11962058, EBI-11958364;
CC Q5T7P2; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11962058, EBI-10245913;
CC Q5T7P2; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11962058, EBI-12224199;
CC Q5T7P2; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11962058, EBI-11955335;
CC Q5T7P2; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11962058, EBI-11958008;
CC Q5T7P2; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11962058, EBI-10246607;
CC Q5T7P2; O14633: LCE2B; NbExp=3; IntAct=EBI-11962058, EBI-11478468;
CC Q5T7P2; Q5TA81: LCE2C; NbExp=6; IntAct=EBI-11962058, EBI-11973993;
CC Q5T7P2; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11962058, EBI-10246750;
CC Q5T7P2; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11962058, EBI-10246358;
CC Q5T7P2; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11962058, EBI-11955689;
CC Q5T7P2; Q99750: MDFI; NbExp=3; IntAct=EBI-11962058, EBI-724076;
CC Q5T7P2; Q14696: MESD; NbExp=3; IntAct=EBI-11962058, EBI-6165891;
CC Q5T7P2; Q8IV28: NID2; NbExp=3; IntAct=EBI-11962058, EBI-10261509;
CC Q5T7P2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11962058, EBI-22310682;
CC Q5T7P2; O15496: PLA2G10; NbExp=3; IntAct=EBI-11962058, EBI-726466;
CC Q5T7P2; Q9NRY7: PLSCR2; NbExp=3; IntAct=EBI-11962058, EBI-3937430;
CC Q5T7P2; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-11962058, EBI-769257;
CC Q5T7P2; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-11962058, EBI-3918154;
CC Q5T7P2; O76081-6: RGS20; NbExp=3; IntAct=EBI-11962058, EBI-10178530;
CC Q5T7P2; Q92504: SLC39A7; NbExp=3; IntAct=EBI-11962058, EBI-1051105;
CC Q5T7P2; P49901: SMCP; NbExp=3; IntAct=EBI-11962058, EBI-750494;
CC Q5T7P2; O43609: SPRY1; NbExp=3; IntAct=EBI-11962058, EBI-3866665;
CC Q5T7P2; O43610: SPRY3; NbExp=3; IntAct=EBI-11962058, EBI-12290641;
CC Q5T7P2; P01137: TGFB1; NbExp=3; IntAct=EBI-11962058, EBI-779636;
CC Q5T7P2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11962058, EBI-5235829;
CC Q5T7P2; O14817: TSPAN4; NbExp=3; IntAct=EBI-11962058, EBI-8652667;
CC Q5T7P2; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11962058, EBI-11957238;
CC Q5T7P2; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-11962058, EBI-11747707;
CC Q5T7P2; Q7Z783; NbExp=3; IntAct=EBI-11962058, EBI-9088990;
CC Q5T7P2; Q96EJ4; NbExp=3; IntAct=EBI-11962058, EBI-750454;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL162596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1028.1; -.
DR RefSeq; NP_848125.1; NM_178348.2.
DR AlphaFoldDB; Q5T7P2; -.
DR BioGRID; 131638; 69.
DR IntAct; Q5T7P2; 67.
DR STRING; 9606.ENSP00000334869; -.
DR iPTMnet; Q5T7P2; -.
DR PhosphoSitePlus; Q5T7P2; -.
DR BioMuta; LCE1A; -.
DR DMDM; 74745413; -.
DR MassIVE; Q5T7P2; -.
DR PaxDb; Q5T7P2; -.
DR PeptideAtlas; Q5T7P2; -.
DR PRIDE; Q5T7P2; -.
DR ProteomicsDB; 64673; -.
DR Antibodypedia; 54232; 92 antibodies from 17 providers.
DR DNASU; 353131; -.
DR Ensembl; ENST00000335123.4; ENSP00000334869.2; ENSG00000186844.6.
DR GeneID; 353131; -.
DR KEGG; hsa:353131; -.
DR MANE-Select; ENST00000335123.4; ENSP00000334869.2; NM_178348.2; NP_848125.1.
DR UCSC; uc010pdw.3; human.
DR CTD; 353131; -.
DR DisGeNET; 353131; -.
DR GeneCards; LCE1A; -.
DR HGNC; HGNC:29459; LCE1A.
DR HPA; ENSG00000186844; Tissue enriched (skin).
DR MIM; 612603; gene.
DR neXtProt; NX_Q5T7P2; -.
DR OpenTargets; ENSG00000186844; -.
DR PharmGKB; PA134885053; -.
DR VEuPathDB; HostDB:ENSG00000186844; -.
DR eggNOG; ENOG502TBWQ; Eukaryota.
DR GeneTree; ENSGT00950000183312; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR OMA; GSSCCHE; -.
DR PathwayCommons; Q5T7P2; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T7P2; -.
DR BioGRID-ORCS; 353131; 331 hits in 988 CRISPR screens.
DR Pharos; Q5T7P2; Tbio.
DR PRO; PR:Q5T7P2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T7P2; protein.
DR Bgee; ENSG00000186844; Expressed in skin of leg and 57 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 2.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..110
FT /note="Late cornified envelope protein 1A"
FT /id="PRO_0000235324"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 10982 MW; 01F8EF018C201B30 CRC64;
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGGC
SSGGGGCCLS HHRRHRSHRH RLQSSGCCSQ PSGGSSCCGG DSGQHSGGCC
