LCE1B_DANRE
ID LCE1B_DANRE Reviewed; 503 AA.
AC Q5TYS0; A4FUK5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Lactation elevated protein 1 homolog B;
GN Name=lace1b; ORFNames=si:ch211-278n15.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AFG1 ATPase family. {ECO:0000305}.
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DR EMBL; BX927123; CAH68958.1; -; Genomic_DNA.
DR EMBL; BC115066; AAI15067.1; -; mRNA.
DR RefSeq; NP_001020653.2; NM_001025482.2.
DR AlphaFoldDB; Q5TYS0; -.
DR STRING; 7955.ENSDARP00000105122; -.
DR PaxDb; Q5TYS0; -.
DR Ensembl; ENSDART00000062978; ENSDARP00000062977; ENSDARG00000042902.
DR GeneID; 555926; -.
DR KEGG; dre:555926; -.
DR CTD; 555926; -.
DR ZFIN; ZDB-GENE-041014-178; afg1lb.
DR eggNOG; KOG2383; Eukaryota.
DR GeneTree; ENSGT00390000013227; -.
DR HOGENOM; CLU_008681_3_1_1; -.
DR InParanoid; Q5TYS0; -.
DR OMA; KRLHFNS; -.
DR OrthoDB; 702840at2759; -.
DR PhylomeDB; Q5TYS0; -.
DR PRO; PR:Q5TYS0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000042902; Expressed in tail and 20 other tissues.
DR ExpressionAtlas; Q5TYS0; baseline.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0003341; P:cilium movement; IMP:ZFIN.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR005654; ATPase_AFG1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12169; PTHR12169; 1.
DR Pfam; PF03969; AFG1_ATPase; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..503
FT /note="Lactation elevated protein 1 homolog B"
FT /id="PRO_0000279524"
FT REGION 108..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 68
FT /note="F -> S (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
FT CONFLICT 72
FT /note="R -> Q (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="D -> E (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="I -> N (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="F -> Y (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
FT CONFLICT 467
FT /note="I -> M (in Ref. 2; AAI15067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 503 AA; 57601 MW; FEFDB55402A5CDFF CRC64;
MAAYASRWRT DCLLRLVFKK TRLSKQVCCE VCKASRGCST TSTGHTSTSA PWPVYGRLVT
HYDSLVHFGS LRKDPQQRTA LLQLEELTRV LTDYTNIPIL LPQPKDCLQN QPTSELQDKV
GSRETVNICR PDENVSNEKE DQQEESSKPH PPQGYYIYGN VGTGKTMLMD LFYSFVENRR
KKRVHFNGFM LDVHRRIHKL KQSLPKRRIG KMTMYDPIFP VAMEIAEETC LICFDEFQVV
DIADAMILKQ LFEGLFKCGV VVVATSNRPP EELYKNGLQR AAFVPFIGVL KEYCRIVSLD
TGIDFRTREM KPAGRLYYIS SEPDAENAVN ALFEELAFRQ NDVTRPRVLN VQGREVTLSR
TCGTIADCSF QELCEQPLGA GDYLEIARCF DTVIIRNVPY LQLGMKDQAR RFTTLIDNFY
DQKVRVVMLA DAPLDRLLDQ GQMTGEEARD RLMLDELGLT DEASKRITLF TADEEIFAFQ
RTVSRLAEMQ TEQYWISGDR SQS
