LCE1B_HUMAN
ID LCE1B_HUMAN Reviewed; 118 AA.
AC Q5T7P3; A4IF40;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Late cornified envelope protein 1B;
DE AltName: Full=Late envelope protein 2;
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 2A;
GN Name=LCE1B; Synonyms=LEP2, SPRL2A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5T7P3; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10245913, EBI-10173507;
CC Q5T7P3; Q7L4P6: BEND5; NbExp=3; IntAct=EBI-10245913, EBI-724373;
CC Q5T7P3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10245913, EBI-3867333;
CC Q5T7P3; P23142-4: FBLN1; NbExp=3; IntAct=EBI-10245913, EBI-11956479;
CC Q5T7P3; Q9BTY2: FUCA2; NbExp=3; IntAct=EBI-10245913, EBI-9050116;
CC Q5T7P3; P28799: GRN; NbExp=3; IntAct=EBI-10245913, EBI-747754;
CC Q5T7P3; P49639: HOXA1; NbExp=13; IntAct=EBI-10245913, EBI-740785;
CC Q5T7P3; P42858: HTT; NbExp=15; IntAct=EBI-10245913, EBI-466029;
CC Q5T7P3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10245913, EBI-10975473;
CC Q5T7P3; Q15323: KRT31; NbExp=3; IntAct=EBI-10245913, EBI-948001;
CC Q5T7P3; Q8IUG1: KRTAP1-3; NbExp=5; IntAct=EBI-10245913, EBI-11749135;
CC Q5T7P3; Q9BYS1: KRTAP1-5; NbExp=4; IntAct=EBI-10245913, EBI-11741292;
CC Q5T7P3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10245913, EBI-10217483;
CC Q5T7P3; P60370: KRTAP10-5; NbExp=10; IntAct=EBI-10245913, EBI-10172150;
CC Q5T7P3; P60409: KRTAP10-7; NbExp=9; IntAct=EBI-10245913, EBI-10172290;
CC Q5T7P3; P60410: KRTAP10-8; NbExp=10; IntAct=EBI-10245913, EBI-10171774;
CC Q5T7P3; P60411: KRTAP10-9; NbExp=12; IntAct=EBI-10245913, EBI-10172052;
CC Q5T7P3; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10245913, EBI-1052037;
CC Q5T7P3; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-10245913, EBI-10210845;
CC Q5T7P3; P60328: KRTAP12-3; NbExp=4; IntAct=EBI-10245913, EBI-11953334;
CC Q5T7P3; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-10245913, EBI-11988175;
CC Q5T7P3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10245913, EBI-14065470;
CC Q5T7P3; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10245913, EBI-9996449;
CC Q5T7P3; Q9BYR7: KRTAP3-2; NbExp=8; IntAct=EBI-10245913, EBI-751260;
CC Q5T7P3; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-10245913, EBI-11957260;
CC Q5T7P3; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-10245913, EBI-10302392;
CC Q5T7P3; Q9BQ66: KRTAP4-12; NbExp=7; IntAct=EBI-10245913, EBI-739863;
CC Q5T7P3; Q9BYR5: KRTAP4-2; NbExp=7; IntAct=EBI-10245913, EBI-10172511;
CC Q5T7P3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10245913, EBI-11958132;
CC Q5T7P3; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10245913, EBI-11993254;
CC Q5T7P3; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10245913, EBI-11993296;
CC Q5T7P3; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10245913, EBI-11958178;
CC Q5T7P3; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10245913, EBI-11974251;
CC Q5T7P3; Q6L8H1: KRTAP5-4; NbExp=5; IntAct=EBI-10245913, EBI-11963072;
CC Q5T7P3; Q6L8G9: KRTAP5-6; NbExp=5; IntAct=EBI-10245913, EBI-10250562;
CC Q5T7P3; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10245913, EBI-11987425;
CC Q5T7P3; P26371: KRTAP5-9; NbExp=10; IntAct=EBI-10245913, EBI-3958099;
CC Q5T7P3; Q9BYQ4: KRTAP9-2; NbExp=11; IntAct=EBI-10245913, EBI-1044640;
CC Q5T7P3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10245913, EBI-1043191;
CC Q5T7P3; Q9BYQ2: KRTAP9-4; NbExp=4; IntAct=EBI-10245913, EBI-10185730;
CC Q5T7P3; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-10245913, EBI-11958364;
CC Q5T7P3; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10245913, EBI-11962058;
CC Q5T7P3; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10245913, EBI-10245913;
CC Q5T7P3; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10245913, EBI-12224199;
CC Q5T7P3; Q5T752: LCE1D; NbExp=3; IntAct=EBI-10245913, EBI-11741311;
CC Q5T7P3; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10245913, EBI-11955335;
CC Q5T7P3; Q5T754: LCE1F; NbExp=3; IntAct=EBI-10245913, EBI-11958008;
CC Q5T7P3; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10245913, EBI-10246607;
CC Q5T7P3; O14633: LCE2B; NbExp=3; IntAct=EBI-10245913, EBI-11478468;
CC Q5T7P3; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10245913, EBI-11973993;
CC Q5T7P3; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-10245913, EBI-10246750;
CC Q5T7P3; Q5TA77: LCE3B; NbExp=6; IntAct=EBI-10245913, EBI-11974495;
CC Q5T7P3; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-10245913, EBI-10245291;
CC Q5T7P3; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10245913, EBI-10246358;
CC Q5T7P3; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10245913, EBI-11955689;
CC Q5T7P3; Q99750: MDFI; NbExp=4; IntAct=EBI-10245913, EBI-724076;
CC Q5T7P3; P50222: MEOX2; NbExp=3; IntAct=EBI-10245913, EBI-748397;
CC Q5T7P3; O96009: NAPSA; NbExp=3; IntAct=EBI-10245913, EBI-7196415;
CC Q5T7P3; Q7Z3S9: NOTCH2NLA; NbExp=6; IntAct=EBI-10245913, EBI-945833;
CC Q5T7P3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10245913, EBI-22310682;
CC Q5T7P3; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-10245913, EBI-1210753;
CC Q5T7P3; P32242: OTX1; NbExp=5; IntAct=EBI-10245913, EBI-740446;
CC Q5T7P3; P07237: P4HB; NbExp=3; IntAct=EBI-10245913, EBI-395883;
CC Q5T7P3; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10245913, EBI-3918154;
CC Q5T7P3; O76081: RGS20; NbExp=5; IntAct=EBI-10245913, EBI-1052678;
CC Q5T7P3; O76081-6: RGS20; NbExp=6; IntAct=EBI-10245913, EBI-10178530;
CC Q5T7P3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10245913, EBI-396669;
CC Q5T7P3; P78317: RNF4; NbExp=3; IntAct=EBI-10245913, EBI-2340927;
CC Q5T7P3; P49901: SMCP; NbExp=3; IntAct=EBI-10245913, EBI-750494;
CC Q5T7P3; O43609: SPRY1; NbExp=3; IntAct=EBI-10245913, EBI-3866665;
CC Q5T7P3; O43597: SPRY2; NbExp=5; IntAct=EBI-10245913, EBI-742487;
CC Q5T7P3; O43610: SPRY3; NbExp=3; IntAct=EBI-10245913, EBI-12290641;
CC Q5T7P3; P22735: TGM1; NbExp=3; IntAct=EBI-10245913, EBI-2562368;
CC Q5T7P3; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-10245913, EBI-5235829;
CC Q5T7P3; O76024: WFS1; NbExp=3; IntAct=EBI-10245913, EBI-720609;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL162596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53363.1; -; Genomic_DNA.
DR EMBL; BC104232; AAI04233.1; -; mRNA.
DR EMBL; BC104233; AAI04234.1; -; mRNA.
DR CCDS; CCDS1027.1; -.
DR RefSeq; NP_848126.1; NM_178349.1.
DR AlphaFoldDB; Q5T7P3; -.
DR BioGRID; 131639; 74.
DR IntAct; Q5T7P3; 75.
DR STRING; 9606.ENSP00000353203; -.
DR BioMuta; LCE1B; -.
DR DMDM; 74745414; -.
DR MassIVE; Q5T7P3; -.
DR PaxDb; Q5T7P3; -.
DR PeptideAtlas; Q5T7P3; -.
DR PRIDE; Q5T7P3; -.
DR ProteomicsDB; 64674; -.
DR Antibodypedia; 47013; 61 antibodies from 12 providers.
DR DNASU; 353132; -.
DR Ensembl; ENST00000360090.4; ENSP00000353203.3; ENSG00000196734.9.
DR GeneID; 353132; -.
DR KEGG; hsa:353132; -.
DR MANE-Select; ENST00000360090.4; ENSP00000353203.3; NM_178349.2; NP_848126.1.
DR UCSC; uc001faq.3; human.
DR CTD; 353132; -.
DR GeneCards; LCE1B; -.
DR HGNC; HGNC:16611; LCE1B.
DR HPA; ENSG00000196734; Tissue enriched (skin).
DR MIM; 612604; gene.
DR neXtProt; NX_Q5T7P3; -.
DR OpenTargets; ENSG00000196734; -.
DR PharmGKB; PA38171; -.
DR VEuPathDB; HostDB:ENSG00000196734; -.
DR GeneTree; ENSGT01040000241162; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR OMA; TCIPKCP; -.
DR PathwayCommons; Q5T7P3; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T7P3; -.
DR BioGRID-ORCS; 353132; 38 hits in 984 CRISPR screens.
DR GenomeRNAi; 353132; -.
DR Pharos; Q5T7P3; Tbio.
DR PRO; PR:Q5T7P3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T7P3; protein.
DR Bgee; ENSG00000196734; Expressed in upper leg skin and 73 other tissues.
DR Genevisible; Q5T7P3; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 2.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..118
FT /note="Late cornified envelope protein 1B"
FT /id="PRO_0000235325"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 118 AA; 11626 MW; 638887B9EBD82BF5 CRC64;
MSCQQNQQQC QPPPKCIPKC PPKCLTPRCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCC
