LCE1C_HUMAN
ID LCE1C_HUMAN Reviewed; 118 AA.
AC Q5T751;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Late cornified envelope protein 1C;
DE AltName: Full=Late envelope protein 3;
GN Name=LCE1C; Synonyms=LEP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5T751; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-12224199, EBI-10173507;
CC Q5T751; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-12224199, EBI-741528;
CC Q5T751; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-12224199, EBI-947551;
CC Q5T751; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-12224199, EBI-713677;
CC Q5T751; Q02930-3: CREB5; NbExp=3; IntAct=EBI-12224199, EBI-10192698;
CC Q5T751; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12224199, EBI-3867333;
CC Q5T751; Q12805: EFEMP1; NbExp=3; IntAct=EBI-12224199, EBI-536772;
CC Q5T751; O95967: EFEMP2; NbExp=3; IntAct=EBI-12224199, EBI-743414;
CC Q5T751; P23142-4: FBLN1; NbExp=3; IntAct=EBI-12224199, EBI-11956479;
CC Q5T751; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-12224199, EBI-11978177;
CC Q5T751; P49639: HOXA1; NbExp=3; IntAct=EBI-12224199, EBI-740785;
CC Q5T751; P60370: KRTAP10-5; NbExp=5; IntAct=EBI-12224199, EBI-10172150;
CC Q5T751; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12224199, EBI-10171774;
CC Q5T751; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-12224199, EBI-10210845;
CC Q5T751; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-12224199, EBI-10176379;
CC Q5T751; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12224199, EBI-11953334;
CC Q5T751; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-12224199, EBI-10176396;
CC Q5T751; Q9BYQ6: KRTAP4-11; NbExp=5; IntAct=EBI-12224199, EBI-10302392;
CC Q5T751; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-12224199, EBI-739863;
CC Q5T751; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12224199, EBI-10172511;
CC Q5T751; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-12224199, EBI-11958132;
CC Q5T751; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-12224199, EBI-11993254;
CC Q5T751; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-12224199, EBI-11993296;
CC Q5T751; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-12224199, EBI-11958178;
CC Q5T751; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-12224199, EBI-11974251;
CC Q5T751; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-12224199, EBI-11963072;
CC Q5T751; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-12224199, EBI-10250562;
CC Q5T751; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12224199, EBI-3958099;
CC Q5T751; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-12224199, EBI-1043191;
CC Q5T751; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-12224199, EBI-11958364;
CC Q5T751; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-12224199, EBI-11962058;
CC Q5T751; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-12224199, EBI-10245913;
CC Q5T751; Q5T752: LCE1D; NbExp=3; IntAct=EBI-12224199, EBI-11741311;
CC Q5T751; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12224199, EBI-11958008;
CC Q5T751; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-12224199, EBI-10246607;
CC Q5T751; O14633: LCE2B; NbExp=3; IntAct=EBI-12224199, EBI-11478468;
CC Q5T751; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-12224199, EBI-11973993;
CC Q5T751; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-12224199, EBI-10246750;
CC Q5T751; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-12224199, EBI-9394625;
CC Q5T751; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-12224199, EBI-11974495;
CC Q5T751; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-12224199, EBI-10246358;
CC Q5T751; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-12224199, EBI-11955689;
CC Q5T751; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-12224199, EBI-2683507;
CC Q5T751; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-12224199, EBI-6979889;
CC Q5T751; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12224199, EBI-741158;
CC Q5T751; Q9HB63: NTN4; NbExp=3; IntAct=EBI-12224199, EBI-743459;
CC Q5T751; P61970: NUTF2; NbExp=3; IntAct=EBI-12224199, EBI-591778;
CC Q5T751; Q14990: ODF1; NbExp=3; IntAct=EBI-12224199, EBI-10234557;
CC Q5T751; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-12224199, EBI-10277776;
CC Q5T751; P32242: OTX1; NbExp=3; IntAct=EBI-12224199, EBI-740446;
CC Q5T751; O15496: PLA2G10; NbExp=3; IntAct=EBI-12224199, EBI-726466;
CC Q5T751; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-12224199, EBI-750734;
CC Q5T751; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12224199, EBI-769257;
CC Q5T751; Q12837: POU4F2; NbExp=3; IntAct=EBI-12224199, EBI-17236143;
CC Q5T751; P20618: PSMB1; NbExp=3; IntAct=EBI-12224199, EBI-372273;
CC Q5T751; Q92504: SLC39A7; NbExp=3; IntAct=EBI-12224199, EBI-1051105;
CC Q5T751; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-12224199, EBI-7082156;
CC Q5T751; O43609: SPRY1; NbExp=3; IntAct=EBI-12224199, EBI-3866665;
CC Q5T751; P01137: TGFB1; NbExp=3; IntAct=EBI-12224199, EBI-779636;
CC Q5T751; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-12224199, EBI-5235829;
CC Q5T751; Q6EMK4: VASN; NbExp=3; IntAct=EBI-12224199, EBI-10249550;
CC Q5T751; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-12224199, EBI-11957238;
CC Q5T751; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-12224199, EBI-11747707;
CC Q5T751; Q7Z783; NbExp=3; IntAct=EBI-12224199, EBI-9088990;
CC Q5T751; Q96EJ4; NbExp=3; IntAct=EBI-12224199, EBI-750454;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL353779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1026.1; -.
DR RefSeq; NP_848128.1; NM_178351.3.
DR AlphaFoldDB; Q5T751; -.
DR BioGRID; 131640; 68.
DR IntAct; Q5T751; 65.
DR STRING; 9606.ENSP00000475270; -.
DR GlyGen; Q5T751; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5T751; -.
DR PhosphoSitePlus; Q5T751; -.
DR BioMuta; LCE1C; -.
DR DMDM; 74745321; -.
DR MassIVE; Q5T751; -.
DR PaxDb; Q5T751; -.
DR PeptideAtlas; Q5T751; -.
DR PRIDE; Q5T751; -.
DR DNASU; 353133; -.
DR Ensembl; ENST00000607093.2; ENSP00000475270.1; ENSG00000197084.6.
DR GeneID; 353133; -.
DR KEGG; hsa:353133; -.
DR MANE-Select; ENST00000607093.2; ENSP00000475270.1; NM_178351.4; NP_848128.1.
DR UCSC; uc031uzj.2; human.
DR CTD; 353133; -.
DR DisGeNET; 353133; -.
DR GeneCards; LCE1C; -.
DR HGNC; HGNC:29464; LCE1C.
DR HPA; ENSG00000197084; Tissue enriched (skin).
DR MIM; 612605; gene.
DR neXtProt; NX_Q5T751; -.
DR OpenTargets; ENSG00000197084; -.
DR PharmGKB; PA134895875; -.
DR VEuPathDB; HostDB:ENSG00000197084; -.
DR GeneTree; ENSGT00950000183278; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR OMA; CCSISAG; -.
DR PathwayCommons; Q5T751; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T751; -.
DR BioGRID-ORCS; 353133; 369 hits in 986 CRISPR screens.
DR GenomeRNAi; 353133; -.
DR Pharos; Q5T751; Tdark.
DR PRO; PR:Q5T751; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T751; protein.
DR Bgee; ENSG00000197084; Expressed in skin of leg and 63 other tissues.
DR ExpressionAtlas; Q5T751; baseline and differential.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 3.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..118
FT /note="Late cornified envelope protein 1C"
FT /id="PRO_0000235326"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 16
FT /note="C -> Y (in dbSNP:rs2006940)"
FT /id="VAR_053481"
SQ SEQUENCE 118 AA; 11543 MW; B1163143D1292259 CRC64;
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS GGSSCCGGGS GQHSGGCC
