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LCE1E_HUMAN
ID   LCE1E_HUMAN             Reviewed;         118 AA.
AC   Q5T753; D3DV30;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Late cornified envelope protein 1E;
DE   AltName: Full=Late envelope protein 5;
GN   Name=LCE1E; Synonyms=LEP5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX   PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA   Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA   Byrne C.;
RT   "Late cornified envelope family in differentiating epithelia -- response to
RT   calcium and ultraviolet irradiation.";
RL   J. Invest. Dermatol. 124:1062-1070(2005).
CC   -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC   -!- INTERACTION:
CC       Q5T753; P05187: ALPP; NbExp=3; IntAct=EBI-11955335, EBI-1211484;
CC       Q5T753; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11955335, EBI-744545;
CC       Q5T753; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11955335, EBI-3867333;
CC       Q5T753; O95967: EFEMP2; NbExp=3; IntAct=EBI-11955335, EBI-743414;
CC       Q5T753; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-11955335, EBI-8468186;
CC       Q5T753; Q9BTY2: FUCA2; NbExp=3; IntAct=EBI-11955335, EBI-9050116;
CC       Q5T753; P28799: GRN; NbExp=3; IntAct=EBI-11955335, EBI-747754;
CC       Q5T753; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11955335, EBI-11959885;
CC       Q5T753; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11955335, EBI-11749135;
CC       Q5T753; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11955335, EBI-11741292;
CC       Q5T753; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-11955335, EBI-11955579;
CC       Q5T753; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11955335, EBI-10217483;
CC       Q5T753; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11955335, EBI-10172150;
CC       Q5T753; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11955335, EBI-12012928;
CC       Q5T753; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11955335, EBI-10171774;
CC       Q5T753; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11955335, EBI-10172052;
CC       Q5T753; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11955335, EBI-10210845;
CC       Q5T753; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11955335, EBI-11953334;
CC       Q5T753; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-11955335, EBI-10176396;
CC       Q5T753; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11955335, EBI-11988175;
CC       Q5T753; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11955335, EBI-14065470;
CC       Q5T753; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11955335, EBI-10302392;
CC       Q5T753; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-11955335, EBI-739863;
CC       Q5T753; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11955335, EBI-10172511;
CC       Q5T753; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11955335, EBI-11958132;
CC       Q5T753; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11955335, EBI-11993254;
CC       Q5T753; Q6L8G4: KRTAP5-11; NbExp=4; IntAct=EBI-11955335, EBI-11993296;
CC       Q5T753; Q701N4: KRTAP5-2; NbExp=5; IntAct=EBI-11955335, EBI-11958178;
CC       Q5T753; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11955335, EBI-11963072;
CC       Q5T753; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11955335, EBI-10250562;
CC       Q5T753; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11955335, EBI-11987425;
CC       Q5T753; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-11955335, EBI-3958099;
CC       Q5T753; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-11955335, EBI-1044640;
CC       Q5T753; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11955335, EBI-1043191;
CC       Q5T753; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11955335, EBI-11958364;
CC       Q5T753; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11955335, EBI-11962058;
CC       Q5T753; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11955335, EBI-10245913;
CC       Q5T753; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11955335, EBI-11741311;
CC       Q5T753; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11955335, EBI-11955335;
CC       Q5T753; Q5T754: LCE1F; NbExp=6; IntAct=EBI-11955335, EBI-11958008;
CC       Q5T753; O14633: LCE2B; NbExp=3; IntAct=EBI-11955335, EBI-11478468;
CC       Q5T753; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11955335, EBI-11973993;
CC       Q5T753; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11955335, EBI-11974495;
CC       Q5T753; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-11955335, EBI-10246358;
CC       Q5T753; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11955335, EBI-11955689;
CC       Q5T753; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-11955335, EBI-2683507;
CC       Q5T753; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11955335, EBI-16439278;
CC       Q5T753; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11955335, EBI-22310682;
CC       Q5T753; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11955335, EBI-741158;
CC       Q5T753; O75928-2: PIAS2; NbExp=3; IntAct=EBI-11955335, EBI-348567;
CC       Q5T753; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-11955335, EBI-3918154;
CC       Q5T753; P78317: RNF4; NbExp=3; IntAct=EBI-11955335, EBI-2340927;
CC       Q5T753; P49901: SMCP; NbExp=3; IntAct=EBI-11955335, EBI-750494;
CC       Q5T753; P22735: TGM1; NbExp=3; IntAct=EBI-11955335, EBI-2562368;
CC       Q5T753; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11955335, EBI-5235829;
CC       Q5T753; Q8N3Z6: ZCCHC7; NbExp=3; IntAct=EBI-11955335, EBI-7265024;
CC   -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC       adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC       esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC       or placenta. {ECO:0000269|PubMed:15854049}.
CC   -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC   -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC   -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR   EMBL; AL353779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471121; EAW53366.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53367.1; -; Genomic_DNA.
DR   CCDS; CCDS1024.1; -.
DR   RefSeq; NP_848130.1; NM_178353.1.
DR   AlphaFoldDB; Q5T753; -.
DR   BioGRID; 131642; 60.
DR   IntAct; Q5T753; 55.
DR   STRING; 9606.ENSP00000357759; -.
DR   iPTMnet; Q5T753; -.
DR   PhosphoSitePlus; Q5T753; -.
DR   BioMuta; LCE1E; -.
DR   DMDM; 74745323; -.
DR   MassIVE; Q5T753; -.
DR   PaxDb; Q5T753; -.
DR   PeptideAtlas; Q5T753; -.
DR   PRIDE; Q5T753; -.
DR   DNASU; 353135; -.
DR   Ensembl; ENST00000368770.4; ENSP00000357759.3; ENSG00000186226.9.
DR   Ensembl; ENST00000368771.1; ENSP00000357760.1; ENSG00000186226.9.
DR   GeneID; 353135; -.
DR   KEGG; hsa:353135; -.
DR   MANE-Select; ENST00000368770.4; ENSP00000357759.3; NM_178353.2; NP_848130.1.
DR   UCSC; uc001fan.4; human.
DR   CTD; 353135; -.
DR   DisGeNET; 353135; -.
DR   GeneCards; LCE1E; -.
DR   HGNC; HGNC:29466; LCE1E.
DR   HPA; ENSG00000186226; Tissue enriched (skin).
DR   MIM; 612607; gene.
DR   neXtProt; NX_Q5T753; -.
DR   OpenTargets; ENSG00000186226; -.
DR   PharmGKB; PA134866413; -.
DR   VEuPathDB; HostDB:ENSG00000186226; -.
DR   GeneTree; ENSGT00950000183301; -.
DR   HOGENOM; CLU_152038_0_0_1; -.
DR   OMA; CPPKHPP; -.
DR   PathwayCommons; Q5T753; -.
DR   Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR   SignaLink; Q5T753; -.
DR   BioGRID-ORCS; 353135; 328 hits in 983 CRISPR screens.
DR   GenomeRNAi; 353135; -.
DR   Pharos; Q5T753; Tdark.
DR   PRO; PR:Q5T753; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5T753; protein.
DR   Bgee; ENSG00000186226; Expressed in skin of leg and 59 other tissues.
DR   ExpressionAtlas; Q5T753; baseline and differential.
DR   Genevisible; Q5T753; HS.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   InterPro; IPR028205; LCE.
DR   Pfam; PF14672; LCE; 3.
PE   1: Evidence at protein level;
KW   Keratinization; Reference proteome.
FT   CHAIN           1..118
FT                   /note="Late cornified envelope protein 1E"
FT                   /id="PRO_0000235328"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         59
FT                   /note="S -> G (in dbSNP:rs11205106)"
FT                   /id="VAR_060066"
FT   VARIANT         111
FT                   /note="G -> S (in dbSNP:rs56313719)"
FT                   /id="VAR_062117"
SQ   SEQUENCE   118 AA;  11616 MW;  A897B2577ADD89A9 CRC64;
     MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGSC
     GSSSGGCCSS GGGGCCLSHH RHHRSHRHRP QSSDCCSQPS GGSSCCGGGS GQHSGGCC
 
 
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