LCE1F_HUMAN
ID LCE1F_HUMAN Reviewed; 118 AA.
AC Q5T754;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Late cornified envelope protein 1F;
DE AltName: Full=Late envelope protein 6;
GN Name=LCE1F; Synonyms=LEP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5T754; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11958008, EBI-10173507;
CC Q5T754; P05187: ALPP; NbExp=3; IntAct=EBI-11958008, EBI-1211484;
CC Q5T754; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11958008, EBI-744545;
CC Q5T754; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11958008, EBI-741528;
CC Q5T754; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-11958008, EBI-947551;
CC Q5T754; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11958008, EBI-713677;
CC Q5T754; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-11958008, EBI-14156412;
CC Q5T754; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-11958008, EBI-3867333;
CC Q5T754; P23142-4: FBLN1; NbExp=3; IntAct=EBI-11958008, EBI-11956479;
CC Q5T754; P49639: HOXA1; NbExp=6; IntAct=EBI-11958008, EBI-740785;
CC Q5T754; Q6ZMJ4: IL34; NbExp=3; IntAct=EBI-11958008, EBI-948761;
CC Q5T754; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11958008, EBI-11959885;
CC Q5T754; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11958008, EBI-11749135;
CC Q5T754; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-11958008, EBI-11955579;
CC Q5T754; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11958008, EBI-12012928;
CC Q5T754; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-11958008, EBI-10172290;
CC Q5T754; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-11958008, EBI-10171774;
CC Q5T754; P60411: KRTAP10-9; NbExp=5; IntAct=EBI-11958008, EBI-10172052;
CC Q5T754; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11958008, EBI-1052037;
CC Q5T754; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11958008, EBI-10210845;
CC Q5T754; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11958008, EBI-10176379;
CC Q5T754; P60328: KRTAP12-3; NbExp=7; IntAct=EBI-11958008, EBI-11953334;
CC Q5T754; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-11958008, EBI-10176396;
CC Q5T754; Q9BYR9: KRTAP2-4; NbExp=6; IntAct=EBI-11958008, EBI-14065470;
CC Q5T754; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-11958008, EBI-751260;
CC Q5T754; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11958008, EBI-3957694;
CC Q5T754; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11958008, EBI-10302392;
CC Q5T754; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-11958008, EBI-739863;
CC Q5T754; Q9BYR3: KRTAP4-4; NbExp=6; IntAct=EBI-11958008, EBI-11958132;
CC Q5T754; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11958008, EBI-11993254;
CC Q5T754; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11958008, EBI-11993296;
CC Q5T754; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11958008, EBI-11958178;
CC Q5T754; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11958008, EBI-11974251;
CC Q5T754; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11958008, EBI-11963072;
CC Q5T754; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11958008, EBI-10250562;
CC Q5T754; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-11958008, EBI-3958099;
CC Q5T754; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11958008, EBI-1044640;
CC Q5T754; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-11958008, EBI-1043191;
CC Q5T754; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-11958008, EBI-11958364;
CC Q5T754; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11958008, EBI-11962058;
CC Q5T754; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11958008, EBI-10245913;
CC Q5T754; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11958008, EBI-12224199;
CC Q5T754; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11958008, EBI-11741311;
CC Q5T754; Q5T753: LCE1E; NbExp=6; IntAct=EBI-11958008, EBI-11955335;
CC Q5T754; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11958008, EBI-11958008;
CC Q5T754; O14633: LCE2B; NbExp=5; IntAct=EBI-11958008, EBI-11478468;
CC Q5T754; Q5TA81: LCE2C; NbExp=6; IntAct=EBI-11958008, EBI-11973993;
CC Q5T754; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11958008, EBI-10246750;
CC Q5T754; Q5TA77: LCE3B; NbExp=6; IntAct=EBI-11958008, EBI-11974495;
CC Q5T754; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11958008, EBI-11955689;
CC Q5T754; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-11958008, EBI-2683507;
CC Q5T754; Q99750: MDFI; NbExp=3; IntAct=EBI-11958008, EBI-724076;
CC Q5T754; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11958008, EBI-22310682;
CC Q5T754; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11958008, EBI-741158;
CC Q5T754; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-11958008, EBI-10277776;
CC Q5T754; P32242: OTX1; NbExp=3; IntAct=EBI-11958008, EBI-740446;
CC Q5T754; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11958008, EBI-11956269;
CC Q5T754; Q12837: POU4F2; NbExp=3; IntAct=EBI-11958008, EBI-17236143;
CC Q5T754; P20618: PSMB1; NbExp=3; IntAct=EBI-11958008, EBI-372273;
CC Q5T754; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-11958008, EBI-948156;
CC Q5T754; O76081-6: RGS20; NbExp=3; IntAct=EBI-11958008, EBI-10178530;
CC Q5T754; P78317: RNF4; NbExp=3; IntAct=EBI-11958008, EBI-2340927;
CC Q5T754; Q92504: SLC39A7; NbExp=3; IntAct=EBI-11958008, EBI-1051105;
CC Q5T754; P49901: SMCP; NbExp=3; IntAct=EBI-11958008, EBI-750494;
CC Q5T754; O43609: SPRY1; NbExp=3; IntAct=EBI-11958008, EBI-3866665;
CC Q5T754; O43610: SPRY3; NbExp=3; IntAct=EBI-11958008, EBI-12290641;
CC Q5T754; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-11958008, EBI-5235829;
CC Q5T754; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11958008, EBI-10180829;
CC Q5T754; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11958008, EBI-11957238;
CC Q5T754; Q8IUB2: WFDC3; NbExp=3; IntAct=EBI-11958008, EBI-7963932;
CC Q5T754; Q7Z783; NbExp=3; IntAct=EBI-11958008, EBI-9088990;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. Expression is observed in the fibroblasts.
CC {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL353779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1023.1; -.
DR RefSeq; NP_848131.1; NM_178354.2.
DR AlphaFoldDB; Q5T754; -.
DR BioGRID; 131643; 75.
DR IntAct; Q5T754; 70.
DR STRING; 9606.ENSP00000334187; -.
DR iPTMnet; Q5T754; -.
DR PhosphoSitePlus; Q5T754; -.
DR BioMuta; LCE1F; -.
DR DMDM; 74745324; -.
DR MassIVE; Q5T754; -.
DR PaxDb; Q5T754; -.
DR PeptideAtlas; Q5T754; -.
DR PRIDE; Q5T754; -.
DR ProteomicsDB; 64641; -.
DR DNASU; 353137; -.
DR Ensembl; ENST00000334371.4; ENSP00000334187.2; ENSG00000240386.4.
DR GeneID; 353137; -.
DR KEGG; hsa:353137; -.
DR MANE-Select; ENST00000334371.4; ENSP00000334187.2; NM_178354.3; NP_848131.1.
DR UCSC; uc010pdv.3; human.
DR CTD; 353137; -.
DR GeneCards; LCE1F; -.
DR HGNC; HGNC:29467; LCE1F.
DR HPA; ENSG00000240386; Tissue enriched (skin).
DR MIM; 612608; gene.
DR neXtProt; NX_Q5T754; -.
DR OpenTargets; ENSG00000240386; -.
DR PharmGKB; PA134962947; -.
DR VEuPathDB; HostDB:ENSG00000240386; -.
DR eggNOG; ENOG502TFQW; Eukaryota.
DR GeneTree; ENSGT00950000183301; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR OMA; HGRCYSS; -.
DR PathwayCommons; Q5T754; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T754; -.
DR BioGRID-ORCS; 353137; 298 hits in 988 CRISPR screens.
DR GenomeRNAi; 353137; -.
DR Pharos; Q5T754; Tdark.
DR PRO; PR:Q5T754; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T754; protein.
DR Bgee; ENSG00000240386; Expressed in skin of leg and 63 other tissues.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 2.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..118
FT /note="Late cornified envelope protein 1F"
FT /id="PRO_0000235329"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 118 AA; 11654 MW; 4C937D67D53D2934 CRC64;
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGCC
SSGGGGCCSS GGGGCCLSHH RRRRSHRHRP QSSDCCSQPS AGSSCCGGGS GQHSGGCC
