LCE2A_HUMAN
ID LCE2A_HUMAN Reviewed; 106 AA.
AC Q5TA79; A4QMZ9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Late cornified envelope protein 2A;
DE AltName: Full=Late envelope protein 9;
GN Name=LCE2A; Synonyms=LEP9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY CALCIUM AND UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5TA79; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10246607, EBI-10173507;
CC Q5TA79; Q02930-3: CREB5; NbExp=3; IntAct=EBI-10246607, EBI-10192698;
CC Q5TA79; P07339: CTSD; NbExp=3; IntAct=EBI-10246607, EBI-2115097;
CC Q5TA79; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10246607, EBI-3867333;
CC Q5TA79; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10246607, EBI-10976677;
CC Q5TA79; Q16610: ECM1; NbExp=3; IntAct=EBI-10246607, EBI-947964;
CC Q5TA79; O15354: GPR37; NbExp=3; IntAct=EBI-10246607, EBI-15639515;
CC Q5TA79; P28799: GRN; NbExp=3; IntAct=EBI-10246607, EBI-747754;
CC Q5TA79; P28799-2: GRN; NbExp=3; IntAct=EBI-10246607, EBI-25860013;
CC Q5TA79; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10246607, EBI-11978177;
CC Q5TA79; P49639: HOXA1; NbExp=3; IntAct=EBI-10246607, EBI-740785;
CC Q5TA79; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10246607, EBI-11749135;
CC Q5TA79; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-10246607, EBI-10172150;
CC Q5TA79; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10246607, EBI-10172290;
CC Q5TA79; P60410: KRTAP10-8; NbExp=8; IntAct=EBI-10246607, EBI-10171774;
CC Q5TA79; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10246607, EBI-10172052;
CC Q5TA79; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10246607, EBI-1052037;
CC Q5TA79; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-10246607, EBI-10210845;
CC Q5TA79; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10246607, EBI-10176379;
CC Q5TA79; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10246607, EBI-11953334;
CC Q5TA79; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-10246607, EBI-10176396;
CC Q5TA79; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10246607, EBI-14065470;
CC Q5TA79; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-10246607, EBI-18395721;
CC Q5TA79; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10246607, EBI-751260;
CC Q5TA79; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10246607, EBI-739863;
CC Q5TA79; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10246607, EBI-10172511;
CC Q5TA79; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10246607, EBI-11958132;
CC Q5TA79; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10246607, EBI-11993254;
CC Q5TA79; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10246607, EBI-10250562;
CC Q5TA79; P26371: KRTAP5-9; NbExp=9; IntAct=EBI-10246607, EBI-3958099;
CC Q5TA79; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10246607, EBI-1044640;
CC Q5TA79; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10246607, EBI-1043191;
CC Q5TA79; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10246607, EBI-11958364;
CC Q5TA79; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10246607, EBI-11962058;
CC Q5TA79; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10246607, EBI-10245913;
CC Q5TA79; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10246607, EBI-12224199;
CC Q5TA79; Q5T752: LCE1D; NbExp=6; IntAct=EBI-10246607, EBI-11741311;
CC Q5TA79; O14633: LCE2B; NbExp=3; IntAct=EBI-10246607, EBI-11478468;
CC Q5TA79; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10246607, EBI-11973993;
CC Q5TA79; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-10246607, EBI-9394625;
CC Q5TA79; P50222: MEOX2; NbExp=3; IntAct=EBI-10246607, EBI-748397;
CC Q5TA79; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10246607, EBI-16439278;
CC Q5TA79; P32242: OTX1; NbExp=3; IntAct=EBI-10246607, EBI-740446;
CC Q5TA79; O15496: PLA2G10; NbExp=3; IntAct=EBI-10246607, EBI-726466;
CC Q5TA79; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10246607, EBI-3918154;
CC Q5TA79; O76081-6: RGS20; NbExp=3; IntAct=EBI-10246607, EBI-10178530;
CC Q5TA79; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10246607, EBI-5235340;
CC Q5TA79; O43609: SPRY1; NbExp=3; IntAct=EBI-10246607, EBI-3866665;
CC Q5TA79; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-10246607, EBI-10175576;
CC Q5TA79; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10246607, EBI-5235829;
CC Q5TA79; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10246607, EBI-10249550;
CC Q5TA79; O76024: WFS1; NbExp=3; IntAct=EBI-10246607, EBI-720609;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By calcium and UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53371.1; -; Genomic_DNA.
DR EMBL; BC119707; AAI19708.1; -; mRNA.
DR CCDS; CCDS1021.1; -.
DR RefSeq; NP_848515.1; NM_178428.3.
DR AlphaFoldDB; Q5TA79; -.
DR BioGRID; 131645; 48.
DR IntAct; Q5TA79; 51.
DR STRING; 9606.ENSP00000357768; -.
DR iPTMnet; Q5TA79; -.
DR PhosphoSitePlus; Q5TA79; -.
DR BioMuta; LCE2A; -.
DR MassIVE; Q5TA79; -.
DR PaxDb; Q5TA79; -.
DR PeptideAtlas; Q5TA79; -.
DR PRIDE; Q5TA79; -.
DR ProteomicsDB; 64834; -.
DR Antibodypedia; 76533; 28 antibodies from 5 providers.
DR DNASU; 353139; -.
DR Ensembl; ENST00000368779.2; ENSP00000357768.1; ENSG00000187173.4.
DR GeneID; 353139; -.
DR KEGG; hsa:353139; -.
DR MANE-Select; ENST00000368779.2; ENSP00000357768.1; NM_178428.4; NP_848515.1.
DR UCSC; uc001faj.3; human.
DR CTD; 353139; -.
DR GeneCards; LCE2A; -.
DR HGNC; HGNC:29469; LCE2A.
DR HPA; ENSG00000187173; Tissue enriched (skin).
DR MIM; 612609; gene.
DR neXtProt; NX_Q5TA79; -.
DR OpenTargets; ENSG00000187173; -.
DR PharmGKB; PA134911274; -.
DR VEuPathDB; HostDB:ENSG00000187173; -.
DR eggNOG; ENOG502TDZA; Eukaryota.
DR GeneTree; ENSGT00940000161842; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR OMA; CRPQCPA; -.
DR PathwayCommons; Q5TA79; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5TA79; -.
DR BioGRID-ORCS; 353139; 255 hits in 995 CRISPR screens.
DR GenomeRNAi; 353139; -.
DR Pharos; Q5TA79; Tdark.
DR PRO; PR:Q5TA79; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TA79; protein.
DR Bgee; ENSG00000187173; Expressed in skin of leg and 60 other tissues.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 2.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..106
FT /note="Late cornified envelope protein 2A"
FT /id="PRO_0000235330"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 20
FT /note="C -> Y (in dbSNP:rs58733562)"
FT /id="VAR_062118"
SQ SEQUENCE 106 AA; 10846 MW; 7F29B511D282B6AA CRC64;
MSCQQNQQQC QPPPKCPPKC PPKCPPKCRP QCPAPCPPPV SSCCGPSSGG CCGSSSGGCC
SSGGGGCCLS HHRPRLFHRH RHQSPDCCEC EPSGGSGCCH SSGDCC
