LCE2B_HUMAN
ID LCE2B_HUMAN Reviewed; 110 AA.
AC O14633; Q5TA80;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Late cornified envelope protein 2B;
DE AltName: Full=Late envelope protein 10;
DE AltName: Full=Skin-specific protein Xp5;
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 1B;
GN Name=LCE2B; Synonyms=LEP10, SPRL1B, XP5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin;
RX PubMed=9344646; DOI=10.1006/geno.1997.4952;
RA Zhao X.P., Elder J.T.;
RT "Positional cloning of novel skin-specific genes from the human epidermal
RT differentiation complex.";
RL Genomics 45:250-258(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY CALCIUM AND UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC O14633; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-11478468, EBI-10173507;
CC O14633; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11478468, EBI-713677;
CC O14633; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-11478468, EBI-3867333;
CC O14633; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11478468, EBI-746300;
CC O14633; P28799: GRN; NbExp=3; IntAct=EBI-11478468, EBI-747754;
CC O14633; Q96NT3-2: GUCD1; NbExp=4; IntAct=EBI-11478468, EBI-11978177;
CC O14633; P49639: HOXA1; NbExp=5; IntAct=EBI-11478468, EBI-740785;
CC O14633; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11478468, EBI-11959885;
CC O14633; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11478468, EBI-11749135;
CC O14633; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11478468, EBI-11741292;
CC O14633; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-11478468, EBI-10172290;
CC O14633; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-11478468, EBI-10171774;
CC O14633; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11478468, EBI-10172052;
CC O14633; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11478468, EBI-10210845;
CC O14633; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11478468, EBI-10176379;
CC O14633; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-11478468, EBI-11953334;
CC O14633; Q9BYP8: KRTAP17-1; NbExp=4; IntAct=EBI-11478468, EBI-11988175;
CC O14633; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11478468, EBI-14065470;
CC O14633; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11478468, EBI-3957672;
CC O14633; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-11478468, EBI-9996449;
CC O14633; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-11478468, EBI-3957694;
CC O14633; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-11478468, EBI-739863;
CC O14633; Q9BYR5: KRTAP4-2; NbExp=5; IntAct=EBI-11478468, EBI-10172511;
CC O14633; Q9BYR3: KRTAP4-4; NbExp=6; IntAct=EBI-11478468, EBI-11958132;
CC O14633; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11478468, EBI-11993254;
CC O14633; Q701N4: KRTAP5-2; NbExp=6; IntAct=EBI-11478468, EBI-11958178;
CC O14633; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11478468, EBI-11987425;
CC O14633; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-11478468, EBI-3958099;
CC O14633; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11478468, EBI-11962084;
CC O14633; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-11478468, EBI-1044640;
CC O14633; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11478468, EBI-1043191;
CC O14633; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-11478468, EBI-11958364;
CC O14633; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11478468, EBI-11962058;
CC O14633; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11478468, EBI-10245913;
CC O14633; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11478468, EBI-12224199;
CC O14633; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11478468, EBI-11741311;
CC O14633; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11478468, EBI-11955335;
CC O14633; Q5T754: LCE1F; NbExp=5; IntAct=EBI-11478468, EBI-11958008;
CC O14633; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11478468, EBI-10246607;
CC O14633; O14633: LCE2B; NbExp=3; IntAct=EBI-11478468, EBI-11478468;
CC O14633; Q5TA81: LCE2C; NbExp=7; IntAct=EBI-11478468, EBI-11973993;
CC O14633; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11478468, EBI-10246750;
CC O14633; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11478468, EBI-9394625;
CC O14633; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11478468, EBI-6658837;
CC O14633; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11478468, EBI-10246358;
CC O14633; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11478468, EBI-11955689;
CC O14633; Q99750: MDFI; NbExp=3; IntAct=EBI-11478468, EBI-724076;
CC O14633; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-11478468, EBI-6979889;
CC O14633; P0DPK4: NOTCH2NLC; NbExp=4; IntAct=EBI-11478468, EBI-22310682;
CC O14633; Q92570: NR4A3; NbExp=3; IntAct=EBI-11478468, EBI-13644623;
CC O14633; P32242: OTX1; NbExp=3; IntAct=EBI-11478468, EBI-740446;
CC O14633; O15496: PLA2G10; NbExp=4; IntAct=EBI-11478468, EBI-726466;
CC O14633; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-11478468, EBI-750734;
CC O14633; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-11478468, EBI-769257;
CC O14633; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-11478468, EBI-3918154;
CC O14633; O76081-6: RGS20; NbExp=3; IntAct=EBI-11478468, EBI-10178530;
CC O14633; P78317: RNF4; NbExp=3; IntAct=EBI-11478468, EBI-2340927;
CC O14633; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-11478468, EBI-7082156;
CC O14633; O43610: SPRY3; NbExp=3; IntAct=EBI-11478468, EBI-12290641;
CC O14633; P01137: TGFB1; NbExp=3; IntAct=EBI-11478468, EBI-779636;
CC O14633; Q8IWZ5: TRIM42; NbExp=5; IntAct=EBI-11478468, EBI-5235829;
CC O14633; O14817: TSPAN4; NbExp=3; IntAct=EBI-11478468, EBI-8652667;
CC O14633; Q96EJ4; NbExp=3; IntAct=EBI-11478468, EBI-750454;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049, ECO:0000269|PubMed:9344646}.
CC -!- INDUCTION: By calcium and UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AF005080; AAB83960.1; -; mRNA.
DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53372.1; -; Genomic_DNA.
DR CCDS; CCDS1020.1; -.
DR RefSeq; NP_055172.1; NM_014357.4.
DR AlphaFoldDB; O14633; -.
DR BioGRID; 117630; 67.
DR IntAct; O14633; 63.
DR MINT; O14633; -.
DR STRING; 9606.ENSP00000357769; -.
DR BioMuta; LCE2B; -.
DR MassIVE; O14633; -.
DR PaxDb; O14633; -.
DR PeptideAtlas; O14633; -.
DR PRIDE; O14633; -.
DR Antibodypedia; 53901; 57 antibodies from 12 providers.
DR DNASU; 26239; -.
DR Ensembl; ENST00000368780.4; ENSP00000357769.3; ENSG00000159455.9.
DR GeneID; 26239; -.
DR KEGG; hsa:26239; -.
DR MANE-Select; ENST00000368780.4; ENSP00000357769.3; NM_014357.5; NP_055172.1.
DR UCSC; uc001fai.4; human.
DR CTD; 26239; -.
DR DisGeNET; 26239; -.
DR GeneCards; LCE2B; -.
DR HGNC; HGNC:16610; LCE2B.
DR HPA; ENSG00000159455; Tissue enriched (skin).
DR MIM; 612610; gene.
DR neXtProt; NX_O14633; -.
DR OpenTargets; ENSG00000159455; -.
DR PharmGKB; PA38170; -.
DR VEuPathDB; HostDB:ENSG00000159455; -.
DR eggNOG; ENOG502TDZA; Eukaryota.
DR GeneTree; ENSGT00940000161842; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR InParanoid; O14633; -.
DR OMA; SHHRPRI; -.
DR PathwayCommons; O14633; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; O14633; -.
DR BioGRID-ORCS; 26239; 131 hits in 981 CRISPR screens.
DR GenomeRNAi; 26239; -.
DR Pharos; O14633; Tdark.
DR PRO; PR:O14633; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O14633; protein.
DR Bgee; ENSG00000159455; Expressed in upper arm skin and 83 other tissues.
DR Genevisible; O14633; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 3.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..110
FT /note="Late cornified envelope protein 2B"
FT /id="PRO_0000084366"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 51
FT /note="I -> S (in dbSNP:rs3737859)"
FT /id="VAR_053482"
FT VARIANT 83
FT /note="R -> Q (in dbSNP:rs28391399)"
FT /id="VAR_062119"
SQ SEQUENCE 110 AA; 11219 MW; 861096815ED8D9B3 CRC64;
MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCLPQCPAPC SPAVSSCCGP ISGGCCGPSS
GGCCNSGAGG CCLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCC
