LCE2C_HUMAN
ID LCE2C_HUMAN Reviewed; 110 AA.
AC Q5TA81;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Late cornified envelope protein 2C;
DE AltName: Full=Late envelope protein 11;
GN Name=LCE2C; Synonyms=LEP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY CALCIUM AND UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum.
CC -!- INTERACTION:
CC Q5TA81; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11973993, EBI-10173507;
CC Q5TA81; P05187: ALPP; NbExp=3; IntAct=EBI-11973993, EBI-1211484;
CC Q5TA81; Q9UL15: BAG5; NbExp=3; IntAct=EBI-11973993, EBI-356517;
CC Q5TA81; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-11973993, EBI-946029;
CC Q5TA81; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11973993, EBI-744545;
CC Q5TA81; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11973993, EBI-11977221;
CC Q5TA81; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11973993, EBI-741528;
CC Q5TA81; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11973993, EBI-713677;
CC Q5TA81; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11973993, EBI-10192698;
CC Q5TA81; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-11973993, EBI-14156412;
CC Q5TA81; A8MQ03: CYSRT1; NbExp=4; IntAct=EBI-11973993, EBI-3867333;
CC Q5TA81; Q12805: EFEMP1; NbExp=3; IntAct=EBI-11973993, EBI-536772;
CC Q5TA81; O95967: EFEMP2; NbExp=3; IntAct=EBI-11973993, EBI-743414;
CC Q5TA81; P52797: EFNA3; NbExp=3; IntAct=EBI-11973993, EBI-722730;
CC Q5TA81; A6H8Z2: FAM221B; NbExp=3; IntAct=EBI-11973993, EBI-12006844;
CC Q5TA81; P49639: HOXA1; NbExp=8; IntAct=EBI-11973993, EBI-740785;
CC Q5TA81; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11973993, EBI-11959885;
CC Q5TA81; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11973993, EBI-11749135;
CC Q5TA81; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-11973993, EBI-11955579;
CC Q5TA81; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11973993, EBI-10172150;
CC Q5TA81; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11973993, EBI-12012928;
CC Q5TA81; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-11973993, EBI-10172290;
CC Q5TA81; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11973993, EBI-10171774;
CC Q5TA81; P60411: KRTAP10-9; NbExp=5; IntAct=EBI-11973993, EBI-10172052;
CC Q5TA81; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11973993, EBI-10210845;
CC Q5TA81; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11973993, EBI-11953334;
CC Q5TA81; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-11973993, EBI-10176396;
CC Q5TA81; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11973993, EBI-11988175;
CC Q5TA81; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11973993, EBI-14065470;
CC Q5TA81; Q9BYQ6: KRTAP4-11; NbExp=8; IntAct=EBI-11973993, EBI-10302392;
CC Q5TA81; Q9BQ66: KRTAP4-12; NbExp=4; IntAct=EBI-11973993, EBI-739863;
CC Q5TA81; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11973993, EBI-10172511;
CC Q5TA81; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11973993, EBI-11958132;
CC Q5TA81; Q9BYR2: KRTAP4-5; NbExp=4; IntAct=EBI-11973993, EBI-11993254;
CC Q5TA81; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11973993, EBI-11993296;
CC Q5TA81; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11973993, EBI-11958178;
CC Q5TA81; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11973993, EBI-11974251;
CC Q5TA81; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11973993, EBI-11963072;
CC Q5TA81; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-11973993, EBI-10250562;
CC Q5TA81; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11973993, EBI-11987425;
CC Q5TA81; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11973993, EBI-3958099;
CC Q5TA81; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11973993, EBI-1044640;
CC Q5TA81; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-11973993, EBI-1043191;
CC Q5TA81; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11973993, EBI-11958364;
CC Q5TA81; Q5T7P2: LCE1A; NbExp=6; IntAct=EBI-11973993, EBI-11962058;
CC Q5TA81; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11973993, EBI-10245913;
CC Q5TA81; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11973993, EBI-12224199;
CC Q5TA81; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11973993, EBI-11741311;
CC Q5TA81; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11973993, EBI-11955335;
CC Q5TA81; Q5T754: LCE1F; NbExp=6; IntAct=EBI-11973993, EBI-11958008;
CC Q5TA81; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11973993, EBI-10246607;
CC Q5TA81; O14633: LCE2B; NbExp=7; IntAct=EBI-11973993, EBI-11478468;
CC Q5TA81; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11973993, EBI-11973993;
CC Q5TA81; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11973993, EBI-10246750;
CC Q5TA81; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11973993, EBI-9394625;
CC Q5TA81; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11973993, EBI-11974495;
CC Q5TA81; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11973993, EBI-6658837;
CC Q5TA81; Q5TA78: LCE4A; NbExp=8; IntAct=EBI-11973993, EBI-10246358;
CC Q5TA81; Q5TCM9: LCE5A; NbExp=6; IntAct=EBI-11973993, EBI-11955689;
CC Q5TA81; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-11973993, EBI-2683507;
CC Q5TA81; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-11973993, EBI-6979889;
CC Q5TA81; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11973993, EBI-22310682;
CC Q5TA81; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11973993, EBI-741158;
CC Q5TA81; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11973993, EBI-1210753;
CC Q5TA81; P32242: OTX1; NbExp=3; IntAct=EBI-11973993, EBI-740446;
CC Q5TA81; Q92824-2: PCSK5; NbExp=6; IntAct=EBI-11973993, EBI-11956269;
CC Q5TA81; O75928-2: PIAS2; NbExp=3; IntAct=EBI-11973993, EBI-348567;
CC Q5TA81; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-11973993, EBI-7199479;
CC Q5TA81; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-11973993, EBI-3918154;
CC Q5TA81; O76081-6: RGS20; NbExp=3; IntAct=EBI-11973993, EBI-10178530;
CC Q5TA81; P78317: RNF4; NbExp=5; IntAct=EBI-11973993, EBI-2340927;
CC Q5TA81; Q92504: SLC39A7; NbExp=3; IntAct=EBI-11973993, EBI-1051105;
CC Q5TA81; P49901: SMCP; NbExp=3; IntAct=EBI-11973993, EBI-750494;
CC Q5TA81; O43609: SPRY1; NbExp=3; IntAct=EBI-11973993, EBI-3866665;
CC Q5TA81; Q9BX79-6: STRA6; NbExp=3; IntAct=EBI-11973993, EBI-12140683;
CC Q5TA81; P09758: TACSTD2; NbExp=3; IntAct=EBI-11973993, EBI-4324738;
CC Q5TA81; Q03518: TAP1; NbExp=3; IntAct=EBI-11973993, EBI-747259;
CC Q5TA81; P01137: TGFB1; NbExp=3; IntAct=EBI-11973993, EBI-779636;
CC Q5TA81; O76062: TM7SF2; NbExp=3; IntAct=EBI-11973993, EBI-2115348;
CC Q5TA81; Q8IWZ5: TRIM42; NbExp=8; IntAct=EBI-11973993, EBI-5235829;
CC Q5TA81; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11973993, EBI-10180829;
CC Q5TA81; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11973993, EBI-10249550;
CC Q5TA81; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11973993, EBI-11957238;
CC Q5TA81; Q8WTP9: XAGE3; NbExp=3; IntAct=EBI-11973993, EBI-6448284;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By calcium and UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1019.1; -.
DR RefSeq; NP_848516.1; NM_178429.3.
DR AlphaFoldDB; Q5TA81; -.
DR BioGRID; 131646; 85.
DR IntAct; Q5TA81; 83.
DR STRING; 9606.ENSP00000357772; -.
DR BioMuta; LCE2C; -.
DR MassIVE; Q5TA81; -.
DR PaxDb; Q5TA81; -.
DR PeptideAtlas; Q5TA81; -.
DR PRIDE; Q5TA81; -.
DR DNASU; 353140; -.
DR Ensembl; ENST00000368783.2; ENSP00000357772.1; ENSG00000187180.4.
DR GeneID; 353140; -.
DR KEGG; hsa:353140; -.
DR MANE-Select; ENST00000368783.2; ENSP00000357772.1; NM_178429.5; NP_848516.1.
DR UCSC; uc001fah.5; human.
DR CTD; 353140; -.
DR GeneCards; LCE2C; -.
DR HGNC; HGNC:29460; LCE2C.
DR HPA; ENSG00000187180; Tissue enriched (skin).
DR MIM; 612611; gene.
DR neXtProt; NX_Q5TA81; -.
DR PharmGKB; PA134903160; -.
DR VEuPathDB; HostDB:ENSG00000187180; -.
DR eggNOG; ENOG502TDZA; Eukaryota.
DR GeneTree; ENSGT00940000161842; -.
DR HOGENOM; CLU_152038_0_0_1; -.
DR InParanoid; Q5TA81; -.
DR OMA; QAPDCCE; -.
DR PathwayCommons; Q5TA81; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5TA81; -.
DR BioGRID-ORCS; 353140; 219 hits in 981 CRISPR screens.
DR GenomeRNAi; 353140; -.
DR Pharos; Q5TA81; Tdark.
DR PRO; PR:Q5TA81; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TA81; protein.
DR Bgee; ENSG00000187180; Expressed in skin of leg and 61 other tissues.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 2.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..110
FT /note="Late cornified envelope protein 2C"
FT /id="PRO_0000235331"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 11224 MW; 8E60D6CF50C4482C CRC64;
MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCPPQCPAPC FPAVSSCCGP SSGSCCGPSS
GGCCSSGAGG CSLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCC
