LCE3A_HUMAN
ID LCE3A_HUMAN Reviewed; 89 AA.
AC Q5TA76;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Late cornified envelope protein 3A {ECO:0000303|PubMed:15854049};
DE AltName: Full=Late envelope protein 13 {ECO:0000303|PubMed:15854049};
GN Name=LCE3A {ECO:0000303|PubMed:15854049, ECO:0000312|HGNC:HGNC:29461};
GN Synonyms=LEP13 {ECO:0000303|PubMed:15854049};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=28634035; DOI=10.1016/j.jid.2017.06.003;
RA Niehues H., Tsoi L.C., van der Krieken D.A., Jansen P.A.M.,
RA Oortveld M.A.W., Rodijk-Olthuis D., van Vlijmen I.M.J.J.,
RA Hendriks W.J.A.J., Helder R.W., Bouwstra J.A., van den Bogaard E.H.,
RA Stuart P.E., Nair R.P., Elder J.T., Zeeuwen P.L.J.M., Schalkwijk J.;
RT "Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have
RT Antibacterial Activity.";
RL J. Invest. Dermatol. 137:2380-2388(2017).
CC -!- FUNCTION: A structural component of the cornified envelope of the
CC stratum corneum involved in innate cutaneous host defense (Probable).
CC Possesses defensin-like antimicrobial activity against a broad spectrum
CC of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic
CC species. Upon inflammation, may regulate skin barrier repair by shaping
CC cutaneous microbiota composition and immune response to bacterial
CC antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035,
CC ECO:0000305|PubMed:28634035}.
CC -!- INTERACTION:
CC Q5TA76; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-9394625, EBI-10173507;
CC Q5TA76; P05187: ALPP; NbExp=5; IntAct=EBI-9394625, EBI-1211484;
CC Q5TA76; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-9394625, EBI-741528;
CC Q5TA76; A8MQ03: CYSRT1; NbExp=9; IntAct=EBI-9394625, EBI-3867333;
CC Q5TA76; Q12805: EFEMP1; NbExp=3; IntAct=EBI-9394625, EBI-536772;
CC Q5TA76; O95967: EFEMP2; NbExp=3; IntAct=EBI-9394625, EBI-743414;
CC Q5TA76; P23142-4: FBLN1; NbExp=3; IntAct=EBI-9394625, EBI-11956479;
CC Q5TA76; Q8IUG1: KRTAP1-3; NbExp=5; IntAct=EBI-9394625, EBI-11749135;
CC Q5TA76; Q9BYS1: KRTAP1-5; NbExp=4; IntAct=EBI-9394625, EBI-11741292;
CC Q5TA76; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-9394625, EBI-10172290;
CC Q5TA76; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-9394625, EBI-10171774;
CC Q5TA76; P60411: KRTAP10-9; NbExp=5; IntAct=EBI-9394625, EBI-10172052;
CC Q5TA76; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-9394625, EBI-1052037;
CC Q5TA76; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-9394625, EBI-11953334;
CC Q5TA76; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-9394625, EBI-10176396;
CC Q5TA76; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-9394625, EBI-11988175;
CC Q5TA76; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-9394625, EBI-14065470;
CC Q5TA76; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-9394625, EBI-9996449;
CC Q5TA76; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-9394625, EBI-751260;
CC Q5TA76; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-9394625, EBI-3957694;
CC Q5TA76; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-9394625, EBI-11957260;
CC Q5TA76; Q9BYQ6: KRTAP4-11; NbExp=5; IntAct=EBI-9394625, EBI-10302392;
CC Q5TA76; Q9BQ66: KRTAP4-12; NbExp=8; IntAct=EBI-9394625, EBI-739863;
CC Q5TA76; Q9BYR5: KRTAP4-2; NbExp=4; IntAct=EBI-9394625, EBI-10172511;
CC Q5TA76; Q9BYR3: KRTAP4-4; NbExp=5; IntAct=EBI-9394625, EBI-11958132;
CC Q5TA76; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-9394625, EBI-11993254;
CC Q5TA76; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-9394625, EBI-11993296;
CC Q5TA76; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-9394625, EBI-11958178;
CC Q5TA76; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-9394625, EBI-11974251;
CC Q5TA76; Q6L8H1: KRTAP5-4; NbExp=5; IntAct=EBI-9394625, EBI-11963072;
CC Q5TA76; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-9394625, EBI-10250562;
CC Q5TA76; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-9394625, EBI-11987425;
CC Q5TA76; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-9394625, EBI-3958099;
CC Q5TA76; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-9394625, EBI-1044640;
CC Q5TA76; Q9BYQ3: KRTAP9-3; NbExp=8; IntAct=EBI-9394625, EBI-1043191;
CC Q5TA76; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-9394625, EBI-11958364;
CC Q5TA76; Q5T751: LCE1C; NbExp=3; IntAct=EBI-9394625, EBI-12224199;
CC Q5TA76; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-9394625, EBI-10246607;
CC Q5TA76; O14633: LCE2B; NbExp=3; IntAct=EBI-9394625, EBI-11478468;
CC Q5TA76; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-9394625, EBI-11973993;
CC Q5TA76; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-9394625, EBI-11974495;
CC Q5TA76; P80188: LCN2; NbExp=3; IntAct=EBI-9394625, EBI-11911016;
CC Q5TA76; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-9394625, EBI-2683507;
CC Q5TA76; Q99750: MDFI; NbExp=5; IntAct=EBI-9394625, EBI-724076;
CC Q5TA76; O96009: NAPSA; NbExp=3; IntAct=EBI-9394625, EBI-7196415;
CC Q5TA76; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-9394625, EBI-22310682;
CC Q5TA76; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-9394625, EBI-10277776;
CC Q5TA76; Q9NRY7: PLSCR2; NbExp=3; IntAct=EBI-9394625, EBI-3937430;
CC Q5TA76; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-9394625, EBI-3918154;
CC Q5TA76; O76081-6: RGS20; NbExp=3; IntAct=EBI-9394625, EBI-10178530;
CC Q5TA76; P49901: SMCP; NbExp=3; IntAct=EBI-9394625, EBI-750494;
CC Q5TA76; O43609: SPRY1; NbExp=6; IntAct=EBI-9394625, EBI-3866665;
CC Q5TA76; O43610: SPRY3; NbExp=3; IntAct=EBI-9394625, EBI-12290641;
CC Q5TA76; P01137: TGFB1; NbExp=3; IntAct=EBI-9394625, EBI-779636;
CC Q5TA76; P22735: TGM1; NbExp=3; IntAct=EBI-9394625, EBI-2562368;
CC Q5TA76; Q8IWZ5: TRIM42; NbExp=5; IntAct=EBI-9394625, EBI-5235829;
CC Q5TA76; O14817: TSPAN4; NbExp=3; IntAct=EBI-9394625, EBI-8652667;
CC Q5TA76; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-9394625, EBI-11957238;
CC Q5TA76; B2RUY7: VWC2L; NbExp=6; IntAct=EBI-9394625, EBI-11747707;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: Induced upon stimulation with inflammatory cytokines
CC produced by T-helper 1 cells (IL1A, TNF, IFNG) and T-helper 17 cells
CC (IL17A, IL22). {ECO:0000269|PubMed:28634035}.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1017.1; -.
DR RefSeq; NP_848518.1; NM_178431.1.
DR AlphaFoldDB; Q5TA76; -.
DR BioGRID; 131648; 62.
DR IntAct; Q5TA76; 60.
DR STRING; 9606.ENSP00000335006; -.
DR iPTMnet; Q5TA76; -.
DR PhosphoSitePlus; Q5TA76; -.
DR BioMuta; LCE3A; -.
DR DMDM; 74745783; -.
DR MassIVE; Q5TA76; -.
DR PaxDb; Q5TA76; -.
DR PeptideAtlas; Q5TA76; -.
DR PRIDE; Q5TA76; -.
DR DNASU; 353142; -.
DR Ensembl; ENST00000335674.1; ENSP00000335006.1; ENSG00000185962.1.
DR GeneID; 353142; -.
DR KEGG; hsa:353142; -.
DR MANE-Select; ENST00000335674.1; ENSP00000335006.1; NM_178431.1; NP_848518.1.
DR UCSC; uc010pdt.2; human.
DR CTD; 353142; -.
DR DisGeNET; 353142; -.
DR GeneCards; LCE3A; -.
DR HGNC; HGNC:29461; LCE3A.
DR HPA; ENSG00000185962; Tissue enriched (lymphoid).
DR MIM; 612613; gene.
DR neXtProt; NX_Q5TA76; -.
DR OpenTargets; ENSG00000185962; -.
DR PharmGKB; PA134880553; -.
DR VEuPathDB; HostDB:ENSG00000185962; -.
DR eggNOG; ENOG502TDZ9; Eukaryota.
DR GeneTree; ENSGT00940000163498; -.
DR HOGENOM; CLU_152038_1_0_1; -.
DR OMA; CHRSHRC; -.
DR PathwayCommons; Q5TA76; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5TA76; -.
DR BioGRID-ORCS; 353142; 18 hits in 1058 CRISPR screens.
DR GenomeRNAi; 353142; -.
DR Pharos; Q5TA76; Tbio.
DR PRO; PR:Q5TA76; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TA76; protein.
DR Bgee; ENSG00000185962; Expressed in lower esophagus mucosa and 45 other tissues.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Antimicrobial; Keratinization; Reference proteome.
FT CHAIN 1..89
FT /note="Late cornified envelope protein 3A"
FT /id="PRO_0000235333"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 59
FT /note="R -> C (in dbSNP:rs16834245)"
FT /id="VAR_053484"
SQ SEQUENCE 89 AA; 9146 MW; 5E53A9A5739ABA84 CRC64;
MSCQQNQQQC QPPPKCPAKS PAQCLPPASS SCAPSSGGCG PSSERSCCLS HHRCRRSHRC
RCQSSNSCDR GSGQQGGSSS CGHSSAGCC
