LCE3B_HUMAN
ID LCE3B_HUMAN Reviewed; 95 AA.
AC Q5TA77;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Late cornified envelope protein 3B {ECO:0000303|PubMed:15854049};
DE AltName: Full=Late envelope protein 14 {ECO:0000303|PubMed:15854049};
GN Name=LCE3B {ECO:0000303|PubMed:15854049, ECO:0000312|HGNC:HGNC:29462};
GN Synonyms=LEP14 {ECO:0000303|PubMed:15854049};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
RN [3]
RP FUNCTION.
RX PubMed=28634035; DOI=10.1016/j.jid.2017.06.003;
RA Niehues H., Tsoi L.C., van der Krieken D.A., Jansen P.A.M.,
RA Oortveld M.A.W., Rodijk-Olthuis D., van Vlijmen I.M.J.J.,
RA Hendriks W.J.A.J., Helder R.W., Bouwstra J.A., van den Bogaard E.H.,
RA Stuart P.E., Nair R.P., Elder J.T., Zeeuwen P.L.J.M., Schalkwijk J.;
RT "Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have
RT Antibacterial Activity.";
RL J. Invest. Dermatol. 137:2380-2388(2017).
CC -!- FUNCTION: A structural component of the cornified envelope of the
CC stratum corneum involved in innate cutaneous host defense (Probable).
CC Possesses defensin-like antimicrobial activity against a broad spectrum
CC of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic
CC species. Upon inflammation, may regulate skin barrier repair by shaping
CC cutaneous microbiota composition and immune response to bacterial
CC antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035,
CC ECO:0000305|PubMed:28634035}.
CC -!- INTERACTION:
CC Q5TA77; P05187: ALPP; NbExp=3; IntAct=EBI-11974495, EBI-1211484;
CC Q5TA77; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-11974495, EBI-14156412;
CC Q5TA77; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11974495, EBI-3867333;
CC Q5TA77; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11974495, EBI-11959885;
CC Q5TA77; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11974495, EBI-11749135;
CC Q5TA77; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-11974495, EBI-11955579;
CC Q5TA77; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11974495, EBI-10217483;
CC Q5TA77; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11974495, EBI-10172150;
CC Q5TA77; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11974495, EBI-12012928;
CC Q5TA77; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11974495, EBI-10172290;
CC Q5TA77; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11974495, EBI-10171774;
CC Q5TA77; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11974495, EBI-10172052;
CC Q5TA77; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11974495, EBI-10302392;
CC Q5TA77; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11974495, EBI-739863;
CC Q5TA77; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11974495, EBI-10172511;
CC Q5TA77; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11974495, EBI-11958132;
CC Q5TA77; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11974495, EBI-11993254;
CC Q5TA77; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11974495, EBI-11993296;
CC Q5TA77; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11974495, EBI-11958178;
CC Q5TA77; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11974495, EBI-11963072;
CC Q5TA77; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11974495, EBI-10250562;
CC Q5TA77; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11974495, EBI-11987425;
CC Q5TA77; P26371: KRTAP5-9; NbExp=4; IntAct=EBI-11974495, EBI-3958099;
CC Q5TA77; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11974495, EBI-1044640;
CC Q5TA77; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11974495, EBI-1043191;
CC Q5TA77; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11974495, EBI-11958364;
CC Q5TA77; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-11974495, EBI-10245913;
CC Q5TA77; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11974495, EBI-12224199;
CC Q5TA77; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11974495, EBI-11741311;
CC Q5TA77; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11974495, EBI-11955335;
CC Q5TA77; Q5T754: LCE1F; NbExp=6; IntAct=EBI-11974495, EBI-11958008;
CC Q5TA77; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11974495, EBI-11973993;
CC Q5TA77; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11974495, EBI-9394625;
CC Q5TA77; Q9UGC6: RGS17; NbExp=5; IntAct=EBI-11974495, EBI-3918154;
CC Q5TA77; P78317: RNF4; NbExp=3; IntAct=EBI-11974495, EBI-2340927;
CC Q5TA77; P49901: SMCP; NbExp=3; IntAct=EBI-11974495, EBI-750494;
CC Q5TA77; P01137: TGFB1; NbExp=3; IntAct=EBI-11974495, EBI-779636;
CC Q5TA77; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11974495, EBI-10180829;
CC Q5TA77; Q9UJ78-2: ZMYM5; NbExp=3; IntAct=EBI-11974495, EBI-17634549;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1016.1; -.
DR RefSeq; NP_848520.1; NM_178433.1.
DR AlphaFoldDB; Q5TA77; -.
DR BioGRID; 131649; 40.
DR IntAct; Q5TA77; 39.
DR STRING; 9606.ENSP00000335358; -.
DR PhosphoSitePlus; Q5TA77; -.
DR BioMuta; LCE3B; -.
DR DMDM; 74745784; -.
DR MassIVE; Q5TA77; -.
DR PaxDb; Q5TA77; -.
DR PeptideAtlas; Q5TA77; -.
DR PRIDE; Q5TA77; -.
DR DNASU; 353143; -.
DR Ensembl; ENST00000335633.1; ENSP00000335358.1; ENSG00000187238.5.
DR GeneID; 353143; -.
DR KEGG; hsa:353143; -.
DR MANE-Select; ENST00000335633.1; ENSP00000335358.1; NM_178433.1; NP_848520.1.
DR UCSC; uc010pds.2; human.
DR CTD; 353143; -.
DR DisGeNET; 353143; -.
DR GeneCards; LCE3B; -.
DR HGNC; HGNC:29462; LCE3B.
DR HPA; ENSG00000187238; Tissue enriched (lymphoid).
DR MIM; 612614; gene.
DR neXtProt; NX_Q5TA77; -.
DR OpenTargets; ENSG00000187238; -.
DR PharmGKB; PA134946555; -.
DR VEuPathDB; HostDB:ENSG00000187238; -.
DR eggNOG; ENOG502TDZ9; Eukaryota.
DR GeneTree; ENSGT00940000165404; -.
DR HOGENOM; CLU_152038_1_0_1; -.
DR InParanoid; Q5TA77; -.
DR OMA; CCRSHRC; -.
DR TreeFam; TF338709; -.
DR PathwayCommons; Q5TA77; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5TA77; -.
DR BioGRID-ORCS; 353143; 9 hits in 1035 CRISPR screens.
DR GenomeRNAi; 353143; -.
DR Pharos; Q5TA77; Tbio.
DR PRO; PR:Q5TA77; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TA77; protein.
DR Bgee; ENSG00000187238; Expressed in granulocyte and 7 other tissues.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Antimicrobial; Keratinization; Reference proteome.
FT CHAIN 1..95
FT /note="Late cornified envelope protein 3B"
FT /id="PRO_0000235334"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 95 AA; 9812 MW; D568369F66B8E5B5 CRC64;
MSCQQNQQQC QPLPKCPSPK CPPKSSAQCL PPASSCCAPR PGCCGGPSSE GGCCLSHHRC
CRSHRCRRQS SNSCDRGSGQ QDGASDCGYG SGGCC
