LCE3C_HUMAN
ID LCE3C_HUMAN Reviewed; 94 AA.
AC Q5T5A8; A1L420;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Late cornified envelope protein 3C {ECO:0000303|PubMed:15854049};
DE AltName: Full=Late envelope protein 15 {ECO:0000303|PubMed:15854049};
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 3A {ECO:0000303|PubMed:15854049};
GN Name=LCE3C {ECO:0000303|PubMed:15854049, ECO:0000312|HGNC:HGNC:16612};
GN Synonyms=LEP15 {ECO:0000303|PubMed:15854049}, SPRL3A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
RN [5]
RP FUNCTION.
RX PubMed=28634035; DOI=10.1016/j.jid.2017.06.003;
RA Niehues H., Tsoi L.C., van der Krieken D.A., Jansen P.A.M.,
RA Oortveld M.A.W., Rodijk-Olthuis D., van Vlijmen I.M.J.J.,
RA Hendriks W.J.A.J., Helder R.W., Bouwstra J.A., van den Bogaard E.H.,
RA Stuart P.E., Nair R.P., Elder J.T., Zeeuwen P.L.J.M., Schalkwijk J.;
RT "Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have
RT Antibacterial Activity.";
RL J. Invest. Dermatol. 137:2380-2388(2017).
CC -!- FUNCTION: A structural component of the cornified envelope of the
CC stratum corneum involved in innate cutaneous host defense (Probable).
CC Possesses defensin-like antimicrobial activity against a broad spectrum
CC of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic
CC species. Upon inflammation, may regulate skin barrier repair by shaping
CC cutaneous microbiota composition and immune response to bacterial
CC antigens (PubMed:28634035). {ECO:0000269|PubMed:28634035,
CC ECO:0000305|PubMed:28634035}.
CC -!- INTERACTION:
CC Q5T5A8; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10245291, EBI-10173507;
CC Q5T5A8; P05187: ALPP; NbExp=3; IntAct=EBI-10245291, EBI-1211484;
CC Q5T5A8; Q9UKJ5: CHIC2; NbExp=6; IntAct=EBI-10245291, EBI-741528;
CC Q5T5A8; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-10245291, EBI-14156412;
CC Q5T5A8; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-10245291, EBI-3867333;
CC Q5T5A8; O95967: EFEMP2; NbExp=3; IntAct=EBI-10245291, EBI-743414;
CC Q5T5A8; P28799: GRN; NbExp=3; IntAct=EBI-10245291, EBI-747754;
CC Q5T5A8; P49639: HOXA1; NbExp=3; IntAct=EBI-10245291, EBI-740785;
CC Q5T5A8; Q5T749: KPRP; NbExp=5; IntAct=EBI-10245291, EBI-10981970;
CC Q5T5A8; Q15323: KRT31; NbExp=3; IntAct=EBI-10245291, EBI-948001;
CC Q5T5A8; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10245291, EBI-11959885;
CC Q5T5A8; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10245291, EBI-11749135;
CC Q5T5A8; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10245291, EBI-10217483;
CC Q5T5A8; P60370: KRTAP10-5; NbExp=7; IntAct=EBI-10245291, EBI-10172150;
CC Q5T5A8; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10245291, EBI-10172290;
CC Q5T5A8; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10245291, EBI-10171774;
CC Q5T5A8; P60411: KRTAP10-9; NbExp=10; IntAct=EBI-10245291, EBI-10172052;
CC Q5T5A8; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10245291, EBI-1052037;
CC Q5T5A8; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-10245291, EBI-11953334;
CC Q5T5A8; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-10245291, EBI-11988175;
CC Q5T5A8; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10245291, EBI-14065470;
CC Q5T5A8; Q9BYR7: KRTAP3-2; NbExp=8; IntAct=EBI-10245291, EBI-751260;
CC Q5T5A8; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10245291, EBI-3957694;
CC Q5T5A8; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-10245291, EBI-11957260;
CC Q5T5A8; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-10245291, EBI-10302392;
CC Q5T5A8; Q9BQ66: KRTAP4-12; NbExp=8; IntAct=EBI-10245291, EBI-739863;
CC Q5T5A8; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10245291, EBI-10172511;
CC Q5T5A8; Q9BYR3: KRTAP4-4; NbExp=8; IntAct=EBI-10245291, EBI-11958132;
CC Q5T5A8; Q9BYR2: KRTAP4-5; NbExp=8; IntAct=EBI-10245291, EBI-11993254;
CC Q5T5A8; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10245291, EBI-11993296;
CC Q5T5A8; Q701N4: KRTAP5-2; NbExp=6; IntAct=EBI-10245291, EBI-11958178;
CC Q5T5A8; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10245291, EBI-11974251;
CC Q5T5A8; Q6L8H1: KRTAP5-4; NbExp=5; IntAct=EBI-10245291, EBI-11963072;
CC Q5T5A8; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10245291, EBI-10250562;
CC Q5T5A8; P26371: KRTAP5-9; NbExp=10; IntAct=EBI-10245291, EBI-3958099;
CC Q5T5A8; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-10245291, EBI-1044640;
CC Q5T5A8; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-10245291, EBI-1043191;
CC Q5T5A8; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10245291, EBI-10185730;
CC Q5T5A8; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10245291, EBI-10245913;
CC Q5T5A8; Q99750: MDFI; NbExp=5; IntAct=EBI-10245291, EBI-724076;
CC Q5T5A8; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10245291, EBI-945833;
CC Q5T5A8; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10245291, EBI-22310682;
CC Q5T5A8; Q92824: PCSK5; NbExp=3; IntAct=EBI-10245291, EBI-751290;
CC Q5T5A8; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10245291, EBI-11956269;
CC Q5T5A8; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10245291, EBI-3918154;
CC Q5T5A8; O76081-6: RGS20; NbExp=3; IntAct=EBI-10245291, EBI-10178530;
CC Q5T5A8; O43609: SPRY1; NbExp=3; IntAct=EBI-10245291, EBI-3866665;
CC Q5T5A8; O43597: SPRY2; NbExp=3; IntAct=EBI-10245291, EBI-742487;
CC Q5T5A8; Q8IWZ5: TRIM42; NbExp=5; IntAct=EBI-10245291, EBI-5235829;
CC Q5T5A8; O14817: TSPAN4; NbExp=3; IntAct=EBI-10245291, EBI-8652667;
CC Q5T5A8; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10245291, EBI-625509;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL356426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH878618; EAW50650.1; -; Genomic_DNA.
DR EMBL; BC130365; AAI30366.1; -; mRNA.
DR EMBL; BC130367; AAI30368.1; -; mRNA.
DR CCDS; CCDS1015.1; -.
DR RefSeq; NP_848521.1; NM_178434.2.
DR AlphaFoldDB; Q5T5A8; -.
DR BioGRID; 131650; 55.
DR IntAct; Q5T5A8; 51.
DR STRING; 9606.ENSP00000334644; -.
DR BioMuta; LCE3C; -.
DR DMDM; 74745051; -.
DR MassIVE; Q5T5A8; -.
DR PaxDb; Q5T5A8; -.
DR PeptideAtlas; Q5T5A8; -.
DR PRIDE; Q5T5A8; -.
DR Antibodypedia; 60406; 24 antibodies from 8 providers.
DR DNASU; 353144; -.
DR Ensembl; ENST00000333881.3; ENSP00000334644.3; ENSG00000244057.5.
DR Ensembl; ENST00000684028.1; ENSP00000507204.1; ENSG00000244057.5.
DR GeneID; 353144; -.
DR KEGG; hsa:353144; -.
DR MANE-Select; ENST00000684028.1; ENSP00000507204.1; NM_178434.3; NP_848521.1.
DR UCSC; uc001fac.2; human.
DR CTD; 353144; -.
DR DisGeNET; 353144; -.
DR GeneCards; LCE3C; -.
DR HGNC; HGNC:16612; LCE3C.
DR HPA; ENSG00000244057; Tissue enriched (lymphoid).
DR MIM; 612615; gene.
DR neXtProt; NX_Q5T5A8; -.
DR OpenTargets; ENSG00000244057; -.
DR PharmGKB; PA38407; -.
DR VEuPathDB; HostDB:ENSG00000244057; -.
DR eggNOG; ENOG502TDZ9; Eukaryota.
DR GeneTree; ENSGT00940000163498; -.
DR HOGENOM; CLU_152038_1_0_1; -.
DR InParanoid; Q5T5A8; -.
DR OMA; GCALNSR; -.
DR PhylomeDB; Q5T5A8; -.
DR TreeFam; TF338709; -.
DR PathwayCommons; Q5T5A8; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T5A8; -.
DR BioGRID-ORCS; 353144; 46 hits in 1061 CRISPR screens.
DR ChiTaRS; LCE3C; human.
DR GenomeRNAi; 353144; -.
DR Pharos; Q5T5A8; Tbio.
DR PRO; PR:Q5T5A8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T5A8; protein.
DR Bgee; ENSG00000244057; Expressed in tonsil and 19 other tissues.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Antimicrobial; Keratinization; Reference proteome.
FT CHAIN 1..94
FT /note="Late cornified envelope protein 3C"
FT /id="PRO_0000235335"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 94 AA; 9729 MW; ACA3379E00D9562C CRC64;
MSCQQNQQQC QPPPSCPSPK CPPKSPAQCL PPPSSDCALS SGGCGPSSES GCCLSHHRHF
RSHQCRRQRS NSCDRGSGQQ GGGSCRGHGS GGCC
