LCE3D_HUMAN
ID LCE3D_HUMAN Reviewed; 92 AA.
AC Q9BYE3; Q3MIL1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Late cornified envelope protein 3D;
DE AltName: Full=Late envelope protein 16;
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 6A;
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 6B;
GN Name=LCE3D; Synonyms=LEP16, SPRL6A, SPRL6B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RA Imai Y.;
RT "Human cDNA related with psoriasis.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-43.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q9BYE3; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-6658837, EBI-10173507;
CC Q9BYE3; P05187: ALPP; NbExp=5; IntAct=EBI-6658837, EBI-1211484;
CC Q9BYE3; P48745: CCN3; NbExp=3; IntAct=EBI-6658837, EBI-3904822;
CC Q9BYE3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-6658837, EBI-741528;
CC Q9BYE3; A8MQ03: CYSRT1; NbExp=8; IntAct=EBI-6658837, EBI-3867333;
CC Q9BYE3; Q12805: EFEMP1; NbExp=3; IntAct=EBI-6658837, EBI-536772;
CC Q9BYE3; O95967: EFEMP2; NbExp=3; IntAct=EBI-6658837, EBI-743414;
CC Q9BYE3; P98095: FBLN2; NbExp=3; IntAct=EBI-6658837, EBI-947973;
CC Q9BYE3; Q5T749: KPRP; NbExp=3; IntAct=EBI-6658837, EBI-10981970;
CC Q9BYE3; Q15323: KRT31; NbExp=3; IntAct=EBI-6658837, EBI-948001;
CC Q9BYE3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-6658837, EBI-11959885;
CC Q9BYE3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-6658837, EBI-11749135;
CC Q9BYE3; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-6658837, EBI-11741292;
CC Q9BYE3; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-6658837, EBI-10172150;
CC Q9BYE3; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-6658837, EBI-10172290;
CC Q9BYE3; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-6658837, EBI-10171774;
CC Q9BYE3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-6658837, EBI-10172052;
CC Q9BYE3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-6658837, EBI-11953334;
CC Q9BYE3; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-6658837, EBI-11988175;
CC Q9BYE3; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-6658837, EBI-14065470;
CC Q9BYE3; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-6658837, EBI-9996449;
CC Q9BYE3; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-6658837, EBI-751260;
CC Q9BYE3; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-6658837, EBI-3957694;
CC Q9BYE3; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-6658837, EBI-11957260;
CC Q9BYE3; Q9BQ66: KRTAP4-12; NbExp=8; IntAct=EBI-6658837, EBI-739863;
CC Q9BYE3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-6658837, EBI-10172511;
CC Q9BYE3; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-6658837, EBI-11993254;
CC Q9BYE3; Q6L8H2: KRTAP5-3; NbExp=5; IntAct=EBI-6658837, EBI-11974251;
CC Q9BYE3; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-6658837, EBI-10250562;
CC Q9BYE3; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-6658837, EBI-11987425;
CC Q9BYE3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-6658837, EBI-3958099;
CC Q9BYE3; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-6658837, EBI-1044640;
CC Q9BYE3; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-6658837, EBI-1043191;
CC Q9BYE3; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-6658837, EBI-11958364;
CC Q9BYE3; O14633: LCE2B; NbExp=3; IntAct=EBI-6658837, EBI-11478468;
CC Q9BYE3; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-6658837, EBI-11973993;
CC Q9BYE3; Q99750: MDFI; NbExp=4; IntAct=EBI-6658837, EBI-724076;
CC Q9BYE3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-6658837, EBI-22310682;
CC Q9BYE3; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-6658837, EBI-11956269;
CC Q9BYE3; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-6658837, EBI-3918154;
CC Q9BYE3; O76081-6: RGS20; NbExp=3; IntAct=EBI-6658837, EBI-10178530;
CC Q9BYE3; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-6658837, EBI-10204280;
CC Q9BYE3; O43609: SPRY1; NbExp=4; IntAct=EBI-6658837, EBI-3866665;
CC Q9BYE3; O43610: SPRY3; NbExp=3; IntAct=EBI-6658837, EBI-12290641;
CC Q9BYE3; Q6N022: TENM4; NbExp=3; IntAct=EBI-6658837, EBI-12827077;
CC Q9BYE3; P01137: TGFB1; NbExp=3; IntAct=EBI-6658837, EBI-779636;
CC Q9BYE3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-6658837, EBI-5235829;
CC Q9BYE3; O14817: TSPAN4; NbExp=3; IntAct=EBI-6658837, EBI-8652667;
CC Q9BYE3; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-6658837, EBI-11957238;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AB048288; BAB40643.1; -; mRNA.
DR EMBL; AL356426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069291; AAH69291.1; -; mRNA.
DR EMBL; BC101784; AAI01785.1; -; mRNA.
DR CCDS; CCDS1014.1; -.
DR RefSeq; NP_115952.1; NM_032563.1.
DR AlphaFoldDB; Q9BYE3; -.
DR BioGRID; 124171; 58.
DR IntAct; Q9BYE3; 52.
DR MINT; Q9BYE3; -.
DR STRING; 9606.ENSP00000357776; -.
DR PhosphoSitePlus; Q9BYE3; -.
DR BioMuta; LCE3D; -.
DR DMDM; 74752448; -.
DR MassIVE; Q9BYE3; -.
DR PaxDb; Q9BYE3; -.
DR PeptideAtlas; Q9BYE3; -.
DR PRIDE; Q9BYE3; -.
DR ProteomicsDB; 79629; -.
DR DNASU; 84648; -.
DR Ensembl; ENST00000368787.4; ENSP00000357776.3; ENSG00000163202.5.
DR GeneID; 84648; -.
DR KEGG; hsa:84648; -.
DR MANE-Select; ENST00000368787.4; ENSP00000357776.3; NM_032563.2; NP_115952.1.
DR UCSC; uc001fab.4; human.
DR CTD; 84648; -.
DR DisGeNET; 84648; -.
DR GeneCards; LCE3D; -.
DR HGNC; HGNC:16615; LCE3D.
DR HPA; ENSG00000163202; Tissue enhanced (cervix, lymphoid tissue, vagina).
DR MIM; 612616; gene.
DR neXtProt; NX_Q9BYE3; -.
DR OpenTargets; ENSG00000163202; -.
DR PharmGKB; PA38174; -.
DR VEuPathDB; HostDB:ENSG00000163202; -.
DR eggNOG; ENOG502TDZ9; Eukaryota.
DR GeneTree; ENSGT00940000163905; -.
DR HOGENOM; CLU_152038_1_0_1; -.
DR InParanoid; Q9BYE3; -.
DR OMA; KSPAQCA; -.
DR TreeFam; TF338709; -.
DR PathwayCommons; Q9BYE3; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q9BYE3; -.
DR BioGRID-ORCS; 84648; 83 hits in 984 CRISPR screens.
DR GenomeRNAi; 84648; -.
DR Pharos; Q9BYE3; Tbio.
DR PRO; PR:Q9BYE3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BYE3; protein.
DR Bgee; ENSG00000163202; Expressed in penis and 98 other tissues.
DR Genevisible; Q9BYE3; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..92
FT /note="Late cornified envelope protein 3D"
FT /id="PRO_0000235336"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 43
FT /note="G -> V (in dbSNP:rs512208)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053485"
FT VARIANT 81
FT /note="G -> V (in dbSNP:rs57201979)"
FT /id="VAR_062120"
SQ SEQUENCE 92 AA; 9444 MW; 2B4660C43C442F0D CRC64;
MSCQQNQQQC QPPPKCPSPK CPPKSPVQCL PPASSGCAPS SGGCGPSSEG GCFLNHHRRH
HRCRRQRPNS CDRGSGQQGG GSGCGHGSGG CC
