LCE3E_HUMAN
ID LCE3E_HUMAN Reviewed; 92 AA.
AC Q5T5B0; A2RRM6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Late cornified envelope protein 3E;
DE AltName: Full=Late envelope protein 17;
GN Name=LCE3E; Synonyms=LEP17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY UVB.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5T5B0; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10245456, EBI-10173507;
CC Q5T5B0; P05187: ALPP; NbExp=3; IntAct=EBI-10245456, EBI-1211484;
CC Q5T5B0; A8MQ03: CYSRT1; NbExp=8; IntAct=EBI-10245456, EBI-3867333;
CC Q5T5B0; O95967: EFEMP2; NbExp=3; IntAct=EBI-10245456, EBI-743414;
CC Q5T5B0; P28799: GRN; NbExp=3; IntAct=EBI-10245456, EBI-747754;
CC Q5T5B0; O15499: GSC2; NbExp=3; IntAct=EBI-10245456, EBI-19954058;
CC Q5T5B0; P49639: HOXA1; NbExp=3; IntAct=EBI-10245456, EBI-740785;
CC Q5T5B0; Q5T749: KPRP; NbExp=3; IntAct=EBI-10245456, EBI-10981970;
CC Q5T5B0; Q15323: KRT31; NbExp=3; IntAct=EBI-10245456, EBI-948001;
CC Q5T5B0; Q6A162: KRT40; NbExp=3; IntAct=EBI-10245456, EBI-10171697;
CC Q5T5B0; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10245456, EBI-11959885;
CC Q5T5B0; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10245456, EBI-11749135;
CC Q5T5B0; P60370: KRTAP10-5; NbExp=8; IntAct=EBI-10245456, EBI-10172150;
CC Q5T5B0; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10245456, EBI-12012928;
CC Q5T5B0; P60409: KRTAP10-7; NbExp=8; IntAct=EBI-10245456, EBI-10172290;
CC Q5T5B0; P60410: KRTAP10-8; NbExp=11; IntAct=EBI-10245456, EBI-10171774;
CC Q5T5B0; P60411: KRTAP10-9; NbExp=7; IntAct=EBI-10245456, EBI-10172052;
CC Q5T5B0; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10245456, EBI-11953334;
CC Q5T5B0; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10245456, EBI-751260;
CC Q5T5B0; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10245456, EBI-3957694;
CC Q5T5B0; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-10245456, EBI-11957260;
CC Q5T5B0; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-10245456, EBI-10302392;
CC Q5T5B0; Q9BQ66: KRTAP4-12; NbExp=9; IntAct=EBI-10245456, EBI-739863;
CC Q5T5B0; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10245456, EBI-10172511;
CC Q5T5B0; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10245456, EBI-11958132;
CC Q5T5B0; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-10245456, EBI-11993254;
CC Q5T5B0; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10245456, EBI-11993296;
CC Q5T5B0; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10245456, EBI-11958178;
CC Q5T5B0; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10245456, EBI-11974251;
CC Q5T5B0; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10245456, EBI-10250562;
CC Q5T5B0; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10245456, EBI-11987425;
CC Q5T5B0; P26371: KRTAP5-9; NbExp=9; IntAct=EBI-10245456, EBI-3958099;
CC Q5T5B0; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10245456, EBI-1044640;
CC Q5T5B0; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-10245456, EBI-1043191;
CC Q5T5B0; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10245456, EBI-10185730;
CC Q5T5B0; Q9BYQ0: KRTAP9-8; NbExp=5; IntAct=EBI-10245456, EBI-11958364;
CC Q5T5B0; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-10245456, EBI-2683507;
CC Q5T5B0; Q99750: MDFI; NbExp=8; IntAct=EBI-10245456, EBI-724076;
CC Q5T5B0; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-10245456, EBI-945833;
CC Q5T5B0; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10245456, EBI-22310682;
CC Q5T5B0; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-10245456, EBI-398874;
CC Q5T5B0; Q9NRY7: PLSCR2; NbExp=3; IntAct=EBI-10245456, EBI-3937430;
CC Q5T5B0; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10245456, EBI-3918154;
CC Q5T5B0; O76081: RGS20; NbExp=3; IntAct=EBI-10245456, EBI-1052678;
CC Q5T5B0; O76081-6: RGS20; NbExp=6; IntAct=EBI-10245456, EBI-10178530;
CC Q5T5B0; O43597: SPRY2; NbExp=3; IntAct=EBI-10245456, EBI-742487;
CC Q5T5B0; O43610: SPRY3; NbExp=3; IntAct=EBI-10245456, EBI-12290641;
CC Q5T5B0; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10245456, EBI-5235829;
CC Q5T5B0; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10245456, EBI-11957238;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- INDUCTION: By UVB. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL356426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53378.1; -; Genomic_DNA.
DR EMBL; BC131716; AAI31717.1; -; mRNA.
DR CCDS; CCDS1013.1; -.
DR RefSeq; NP_848522.1; NM_178435.3.
DR RefSeq; XP_011507786.1; XM_011509484.1.
DR AlphaFoldDB; Q5T5B0; -.
DR BioGRID; 131651; 51.
DR IntAct; Q5T5B0; 48.
DR STRING; 9606.ENSP00000357778; -.
DR iPTMnet; Q5T5B0; -.
DR PhosphoSitePlus; Q5T5B0; -.
DR BioMuta; LCE3E; -.
DR DMDM; 74745052; -.
DR MassIVE; Q5T5B0; -.
DR PaxDb; Q5T5B0; -.
DR PeptideAtlas; Q5T5B0; -.
DR PRIDE; Q5T5B0; -.
DR DNASU; 353145; -.
DR Ensembl; ENST00000368789.2; ENSP00000357778.1; ENSG00000185966.4.
DR GeneID; 353145; -.
DR KEGG; hsa:353145; -.
DR MANE-Select; ENST00000368789.2; ENSP00000357778.1; NM_178435.4; NP_848522.1.
DR UCSC; uc001faa.5; human.
DR CTD; 353145; -.
DR DisGeNET; 353145; -.
DR GeneCards; LCE3E; -.
DR HGNC; HGNC:29463; LCE3E.
DR HPA; ENSG00000185966; Tissue enhanced (cervix, lymphoid tissue, vagina).
DR MIM; 612617; gene.
DR neXtProt; NX_Q5T5B0; -.
DR OpenTargets; ENSG00000185966; -.
DR PharmGKB; PA134941153; -.
DR VEuPathDB; HostDB:ENSG00000185966; -.
DR eggNOG; ENOG502TDZ9; Eukaryota.
DR GeneTree; ENSGT00940000163905; -.
DR HOGENOM; CLU_152038_1_0_1; -.
DR InParanoid; Q5T5B0; -.
DR OMA; CDEGSAG; -.
DR TreeFam; TF338709; -.
DR PathwayCommons; Q5T5B0; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T5B0; -.
DR BioGRID-ORCS; 353145; 9 hits in 629 CRISPR screens.
DR GenomeRNAi; 353145; -.
DR Pharos; Q5T5B0; Tdark.
DR PRO; PR:Q5T5B0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T5B0; protein.
DR Bgee; ENSG00000185966; Expressed in skin of leg and 24 other tissues.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..92
FT /note="Late cornified envelope protein 3E"
FT /id="PRO_0000235337"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 92 AA; 9507 MW; BF6DE9D5CD7E849A CRC64;
MSCQQNQKQC QPPPKCPSPK CPPKNPVQCL PPASSGCAPS SGGCGPSSEG GCFLNHHRRH
HRCRRQRSNS CDRGSGQQGG GSGCCHGSGG CC
