LCE4A_HUMAN
ID LCE4A_HUMAN Reviewed; 99 AA.
AC Q5TA78; Q14D97;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Late cornified envelope protein 4A;
DE AltName: Full=Late envelope protein 8;
DE AltName: Full=Small proline-rich-like epidermal differentiation complex protein 4A;
GN Name=LCE4A; Synonyms=LEP8, SPRL4A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=15854049; DOI=10.1111/j.0022-202x.2005.23699.x;
RA Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G.,
RA Byrne C.;
RT "Late cornified envelope family in differentiating epithelia -- response to
RT calcium and ultraviolet irradiation.";
RL J. Invest. Dermatol. 124:1062-1070(2005).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC -!- INTERACTION:
CC Q5TA78; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10246358, EBI-10173507;
CC Q5TA78; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-10246358, EBI-713677;
CC Q5TA78; Q02930-3: CREB5; NbExp=3; IntAct=EBI-10246358, EBI-10192698;
CC Q5TA78; A8MQ03: CYSRT1; NbExp=7; IntAct=EBI-10246358, EBI-3867333;
CC Q5TA78; Q9BTY2: FUCA2; NbExp=3; IntAct=EBI-10246358, EBI-9050116;
CC Q5TA78; P28799: GRN; NbExp=4; IntAct=EBI-10246358, EBI-747754;
CC Q5TA78; P49639: HOXA1; NbExp=9; IntAct=EBI-10246358, EBI-740785;
CC Q5TA78; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10246358, EBI-3918847;
CC Q5TA78; Q15323: KRT31; NbExp=3; IntAct=EBI-10246358, EBI-948001;
CC Q5TA78; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10246358, EBI-11959885;
CC Q5TA78; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10246358, EBI-11749135;
CC Q5TA78; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10246358, EBI-11741292;
CC Q5TA78; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10246358, EBI-10172150;
CC Q5TA78; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10246358, EBI-12012928;
CC Q5TA78; P60409: KRTAP10-7; NbExp=8; IntAct=EBI-10246358, EBI-10172290;
CC Q5TA78; P60410: KRTAP10-8; NbExp=9; IntAct=EBI-10246358, EBI-10171774;
CC Q5TA78; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10246358, EBI-10172052;
CC Q5TA78; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10246358, EBI-10176379;
CC Q5TA78; P60328: KRTAP12-3; NbExp=6; IntAct=EBI-10246358, EBI-11953334;
CC Q5TA78; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-10246358, EBI-10176396;
CC Q5TA78; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-10246358, EBI-11988175;
CC Q5TA78; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10246358, EBI-9996449;
CC Q5TA78; Q9BYR7: KRTAP3-2; NbExp=6; IntAct=EBI-10246358, EBI-751260;
CC Q5TA78; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10246358, EBI-3957694;
CC Q5TA78; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-10246358, EBI-10302392;
CC Q5TA78; Q9BQ66: KRTAP4-12; NbExp=9; IntAct=EBI-10246358, EBI-739863;
CC Q5TA78; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10246358, EBI-10172511;
CC Q5TA78; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10246358, EBI-11958132;
CC Q5TA78; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-10246358, EBI-11993254;
CC Q5TA78; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10246358, EBI-11993296;
CC Q5TA78; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10246358, EBI-11974251;
CC Q5TA78; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-10246358, EBI-11963072;
CC Q5TA78; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10246358, EBI-10250562;
CC Q5TA78; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10246358, EBI-11987425;
CC Q5TA78; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10246358, EBI-3958099;
CC Q5TA78; Q9BYQ4: KRTAP9-2; NbExp=9; IntAct=EBI-10246358, EBI-1044640;
CC Q5TA78; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10246358, EBI-1043191;
CC Q5TA78; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10246358, EBI-10185730;
CC Q5TA78; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10246358, EBI-11958364;
CC Q5TA78; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10246358, EBI-11962058;
CC Q5TA78; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-10246358, EBI-10245913;
CC Q5TA78; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10246358, EBI-12224199;
CC Q5TA78; Q5T753: LCE1E; NbExp=6; IntAct=EBI-10246358, EBI-11955335;
CC Q5TA78; O14633: LCE2B; NbExp=3; IntAct=EBI-10246358, EBI-11478468;
CC Q5TA78; Q5TA81: LCE2C; NbExp=8; IntAct=EBI-10246358, EBI-11973993;
CC Q5TA78; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10246358, EBI-10246358;
CC Q5TA78; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10246358, EBI-11955689;
CC Q5TA78; Q99750: MDFI; NbExp=6; IntAct=EBI-10246358, EBI-724076;
CC Q5TA78; P50222: MEOX2; NbExp=3; IntAct=EBI-10246358, EBI-748397;
CC Q5TA78; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10246358, EBI-22310682;
CC Q5TA78; P32242: OTX1; NbExp=3; IntAct=EBI-10246358, EBI-740446;
CC Q5TA78; P07237: P4HB; NbExp=3; IntAct=EBI-10246358, EBI-395883;
CC Q5TA78; O15162: PLSCR1; NbExp=3; IntAct=EBI-10246358, EBI-740019;
CC Q5TA78; Q9NRY6: PLSCR3; NbExp=6; IntAct=EBI-10246358, EBI-750734;
CC Q5TA78; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10246358, EBI-3918154;
CC Q5TA78; P49795: RGS19; NbExp=3; IntAct=EBI-10246358, EBI-874907;
CC Q5TA78; O76081: RGS20; NbExp=3; IntAct=EBI-10246358, EBI-1052678;
CC Q5TA78; O76081-6: RGS20; NbExp=8; IntAct=EBI-10246358, EBI-10178530;
CC Q5TA78; Q6ZNA4: RNF111; NbExp=3; IntAct=EBI-10246358, EBI-2129175;
CC Q5TA78; Q92504: SLC39A7; NbExp=3; IntAct=EBI-10246358, EBI-1051105;
CC Q5TA78; P49901: SMCP; NbExp=6; IntAct=EBI-10246358, EBI-750494;
CC Q5TA78; O43609: SPRY1; NbExp=3; IntAct=EBI-10246358, EBI-3866665;
CC Q5TA78; O43597: SPRY2; NbExp=3; IntAct=EBI-10246358, EBI-742487;
CC Q5TA78; P22735: TGM1; NbExp=3; IntAct=EBI-10246358, EBI-2562368;
CC Q5TA78; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10246358, EBI-5235829;
CC Q5TA78; O14817: TSPAN4; NbExp=3; IntAct=EBI-10246358, EBI-8652667;
CC Q5TA78; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10246358, EBI-10249550;
CC Q5TA78; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-10246358, EBI-11957238;
CC Q5TA78; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10246358, EBI-625509;
CC -!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in
CC adult trunk skin, adult arm skin, fetal skin, penal skin, vulva,
CC esophagus and tongue. Not expressed in the cervix, rectum, lung, colon,
CC or placenta. {ECO:0000269|PubMed:15854049}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113446; AAI13447.1; -; mRNA.
DR EMBL; BC113448; AAI13449.1; -; mRNA.
DR CCDS; CCDS1022.1; -.
DR RefSeq; NP_848133.1; NM_178356.3.
DR AlphaFoldDB; Q5TA78; -.
DR BioGRID; 128277; 70.
DR IntAct; Q5TA78; 67.
DR STRING; 9606.ENSP00000357766; -.
DR iPTMnet; Q5TA78; -.
DR PhosphoSitePlus; Q5TA78; -.
DR BioMuta; LCE4A; -.
DR DMDM; 74745785; -.
DR MassIVE; Q5TA78; -.
DR PaxDb; Q5TA78; -.
DR PeptideAtlas; Q5TA78; -.
DR PRIDE; Q5TA78; -.
DR DNASU; 199834; -.
DR Ensembl; ENST00000368777.2; ENSP00000357766.1; ENSG00000187170.6.
DR GeneID; 199834; -.
DR KEGG; hsa:199834; -.
DR MANE-Select; ENST00000368777.2; ENSP00000357766.1; NM_001387222.1; NP_001374151.1.
DR UCSC; uc001fak.2; human.
DR CTD; 199834; -.
DR DisGeNET; 199834; -.
DR GeneCards; LCE4A; -.
DR HGNC; HGNC:16613; LCE4A.
DR HPA; ENSG00000187170; Tissue enriched (skin).
DR MIM; 612618; gene.
DR neXtProt; NX_Q5TA78; -.
DR OpenTargets; ENSG00000187170; -.
DR PharmGKB; PA38172; -.
DR VEuPathDB; HostDB:ENSG00000187170; -.
DR eggNOG; ENOG502TKF4; Eukaryota.
DR HOGENOM; CLU_152038_0_0_1; -.
DR InParanoid; Q5TA78; -.
DR OMA; CPIPKYP; -.
DR PathwayCommons; Q5TA78; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5TA78; -.
DR BioGRID-ORCS; 199834; 6 hits in 1024 CRISPR screens.
DR GenomeRNAi; 199834; -.
DR Pharos; Q5TA78; Tdark.
DR PRO; PR:Q5TA78; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TA78; protein.
DR Bgee; ENSG00000187170; Expressed in stromal cell of endometrium and 9 other tissues.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR028205; LCE.
DR Pfam; PF14672; LCE; 1.
PE 1: Evidence at protein level;
KW Keratinization; Reference proteome.
FT CHAIN 1..99
FT /note="Late cornified envelope protein 4A"
FT /id="PRO_0000235338"
FT REGION 78..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 95
FT /note="G -> V (in dbSNP:rs10888510)"
FT /id="VAR_053486"
SQ SEQUENCE 99 AA; 9980 MW; 744CA56F4C488EC6 CRC64;
MSCQQNQQQC QPPPKCPIPK YPPKCPSKCA SSCPPPISSC CGSSSGGCGC CSSEGGGCCL
SHHRHHRSHC HRPKSSNCYG SGSGQQSGGS GCCSGGGCC
