LCE6A_HUMAN
ID LCE6A_HUMAN Reviewed; 80 AA.
AC A0A183;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Late cornified envelope protein 6A;
GN Name=LCE6A; Synonyms=C1orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epidermis;
RX PubMed=17562024; DOI=10.1186/gb-2007-8-6-r107;
RA Toulza E., Mattiuzzo N.R., Galliano M.F., Jonca N., Dossat C., Jacob D.,
RA de Daruvar A., Wincker P., Serre G., Guerrin M.;
RT "Large-scale identification of human genes implicated in epidermal barrier
RT function.";
RL Genome Biol. 8:R107.1-R107.23(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Precursors of the cornified envelope of the stratum corneum.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
CC -!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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DR EMBL; DQ991251; ABJ55982.1; -; mRNA.
DR EMBL; AL162596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44227.1; -.
DR RefSeq; NP_001122072.1; NM_001128600.1.
DR RefSeq; XP_016856816.1; XM_017001327.1.
DR AlphaFoldDB; A0A183; -.
DR STRING; 9606.ENSP00000411070; -.
DR BioMuta; LCE6A; -.
DR MassIVE; A0A183; -.
DR PaxDb; A0A183; -.
DR PeptideAtlas; A0A183; -.
DR PRIDE; A0A183; -.
DR Antibodypedia; 50350; 14 antibodies from 7 providers.
DR DNASU; 448835; -.
DR Ensembl; ENST00000431011.3; ENSP00000411070.2; ENSG00000235942.3.
DR GeneID; 448835; -.
DR KEGG; hsa:448835; -.
DR MANE-Select; ENST00000431011.3; ENSP00000411070.2; NM_001128600.2; NP_001122072.1.
DR UCSC; uc001fas.5; human.
DR CTD; 448835; -.
DR GeneCards; LCE6A; -.
DR HGNC; HGNC:31824; LCE6A.
DR HPA; ENSG00000235942; Tissue enriched (skin).
DR neXtProt; NX_A0A183; -.
DR OpenTargets; ENSG00000235942; -.
DR PharmGKB; PA162393834; -.
DR VEuPathDB; HostDB:ENSG00000235942; -.
DR eggNOG; ENOG502TE13; Eukaryota.
DR GeneTree; ENSGT00940000166289; -.
DR HOGENOM; CLU_2589012_0_0_1; -.
DR InParanoid; A0A183; -.
DR OMA; HSEGCHS; -.
DR OrthoDB; 1616327at2759; -.
DR PhylomeDB; A0A183; -.
DR PathwayCommons; A0A183; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; A0A183; -.
DR BioGRID-ORCS; 448835; 9 hits in 1056 CRISPR screens.
DR GenomeRNAi; 448835; -.
DR Pharos; A0A183; Tdark.
DR PRO; PR:A0A183; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A0A183; protein.
DR Bgee; ENSG00000235942; Expressed in skin of leg and 55 other tissues.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR InterPro; IPR031716; LCE6A.
DR Pfam; PF15858; LCE6A; 1.
PE 3: Inferred from homology;
KW Keratinization; Reference proteome.
FT CHAIN 1..80
FT /note="Late cornified envelope protein 6A"
FT /id="PRO_0000313639"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 80 AA; 9022 MW; 86D70F3A1613BBC4 CRC64;
MSQQKQQSWK PPNVPKCSPP QRSNPCLAPY STPCGAPHSE GCHSSSQRPE VQKPRRARQK
LRCLSRGTTY HCKEEECEGD
