ID   LCFH_HAEIN              Reviewed;         607 AA.
AC   P44446;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative long-chain-fatty-acid--CoA ligase;
DE            EC=6.2.1.3;
DE   AltName: Full=Long-chain acyl-CoA synthetase;
DE            Short=LACS;
GN   OrderedLocusNames=HI_0002;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC         CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC         ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21681.1; -; Genomic_DNA.
DR   PIR; H64041; H64041.
DR   RefSeq; NP_438175.1; NC_000907.1.
DR   AlphaFoldDB; P44446; -.
DR   SMR; P44446; -.
DR   STRING; 71421.HI_0002; -.
DR   EnsemblBacteria; AAC21681; AAC21681; HI_0002.
DR   KEGG; hin:HI_0002; -.
DR   PATRIC; fig|71421.8.peg.2; -.
DR   eggNOG; COG1022; Bacteria.
DR   HOGENOM; CLU_000022_45_5_6; -.
DR   OMA; GEGEKMP; -.
DR   PhylomeDB; P44446; -.
DR   BioCyc; HINF71421:G1GJ1-2-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Fatty acid metabolism; Ligase; Lipid metabolism;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..607
FT                   /note="Putative long-chain-fatty-acid--CoA ligase"
FT                   /id="PRO_0000193123"
SQ   SEQUENCE   607 AA;  69694 MW;  111A5AA7A545D674 CRC64;
     MKIKNRVNMN LDLHFVHRIQ QQAKTRTNMT ALRYKEHGLW RDISWKNFQE QLNQLSRALL
     AHNIDVQDKI AIFAHNMERW TIVDIATLQI RAITVPIYAT NTAQQAEFIL NHADVKILFV
     GDQEQYDQTL EIAHHCPKLQ KIVAMKSTIQ LQQDPLSCTW ESFIKTGSNA QQDELTQRLN
     QKQLSDLFTI IYTSGTTGEP KGVMLDYANL AHQLETHDLS LNVTDQDISL SFLPFSHIFE
     RAWAAYILHR GAILCYLEDT NQVRSALTEI RPTLMCAVPR FYEKIYAAVL DKVQKAPKLR
     QIMFHWAISV GQKYFDLRAN NKAIPFLLKK QFALADKLVL SKLRQLLGGR IKMMPCGGAK
     LEPAIGLFFH AIGINIKLGY GMTETTATVS CWHDFQFNPN SIGTLMPKAE VKIGENNEIL
     VRGGMVMKGY YKKPEETAQA FTEDGFLKTG DAGEFDEQGN LFITDRIKEL MKTSNGKYIA
     PQYIESKIGK DKFIEQIAII ADAKKYVSAL IVPCFDSLEE YAKQLNIKYH DRLELLKNSD
     ILKMFEHRIN AVQKELAHFE QVKKFTLLSQ AFSIKLGEIT PTLKLRRKVI LERYRKQIEA
     MYHSQEA