ID   LCIA_LACLL              Reviewed;          98 AA.
AC   P0A3M7; Q00561;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Lactococcin-A immunity protein;
GN   Name=lciA;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG   Plasmid pNP2.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Biovar diacetylactis WM4;
RX   PubMed=1622271; DOI=10.1128/aem.58.6.1952-1961.1992;
RA   Stoddard G.W., Petzel J.P., van Belkum M.J., Kok J., McKay L.L.;
RT   "Molecular analyses of the lactococcin A gene cluster from Lactococcus
RT   lactis subsp. lactis biovar diacetylactis WM4.";
RL   Appl. Environ. Microbiol. 58:1952-1961(1992).
CC   -!- FUNCTION: Imparts immunity to lactococcin-A to naturally sensitive host
CC       strains.
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DR   EMBL; M90969; AAA92857.1; -; Genomic_DNA.
DR   PIR; E43943; E43943.
DR   RefSeq; WP_015081787.1; NZ_WJUU01000046.1.
DR   PDB; 5LFI; NMR; -; A=1-98.
DR   PDBsum; 5LFI; -.
DR   AlphaFoldDB; P0A3M7; -.
DR   SMR; P0A3M7; -.
DR   DIP; DIP-60871N; -.
DR   IntAct; P0A3M7; 6.
DR   GO; GO:0030153; P:bacteriocin immunity; IEA:UniProtKB-KW.
DR   InterPro; IPR015046; LciA_Immunity-like.
DR   Pfam; PF08951; EntA_Immun; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Bacteriocin immunity; Plasmid.
FT   CHAIN           1..98
FT                   /note="Lactococcin-A immunity protein"
FT                   /id="PRO_0000206197"
FT   STRAND          1..3
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   HELIX           6..21
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   HELIX           26..39
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   TURN            40..42
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   HELIX           45..61
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   HELIX           70..75
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   TURN            76..79
FT                   /evidence="ECO:0007829|PDB:5LFI"
FT   STRAND          85..87
FT                   /evidence="ECO:0007829|PDB:5LFI"
SQ   SEQUENCE   98 AA;  11164 MW;  587FE4DB9ED136E7 CRC64;
     MKKKQIEFEN ELRSMLATAL EKDISQEERN ALNIAEKALD NSEYLPKIIL NLRKALTPLA
     INRTLNHDLS ELYKFITSSK ASNKNLGGGL IMSWGRLF