ID   LCL1_YEAST              Reviewed;         101 AA.
AC   Q02786; D6W3V8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Long chronological lifespan protein 1;
DE   Flags: Precursor;
GN   Name=LCL1; OrderedLocusNames=YPL056C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FLUCONAZOLE RESISTANCE OF DELETION.
RX   PubMed=12702675; DOI=10.1093/genetics/163.4.1287;
RA   Anderson J.B., Sirjusingh C., Parsons A.B., Boone C., Wickens C.,
RA   Cowen L.E., Kohn L.M.;
RT   "Mode of selection and experimental evolution of antifungal drug resistance
RT   in Saccharomyces cerevisiae.";
RL   Genetics 163:1287-1298(2003).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=20421943; DOI=10.1371/journal.pgen.1000921;
RA   Matecic M., Smith D.L., Pan X., Maqani N., Bekiranov S., Boeke J.D.,
RA   Smith J.S.;
RT   "A microarray-based genetic screen for yeast chronological aging factors.";
RL   PLoS Genet. 6:E1000921-E1000921(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Leads to long chronological lifespan.
CC       {ECO:0000269|PubMed:20421943}.
CC   -!- MISCELLANEOUS: Deletion leads to fluconazole resistance.
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DR   EMBL; U39205; AAB68309.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11374.1; -; Genomic_DNA.
DR   PIR; S60934; S60934.
DR   RefSeq; NP_015269.1; NM_001183870.1.
DR   AlphaFoldDB; Q02786; -.
DR   BioGRID; 36124; 84.
DR   DIP; DIP-5555N; -.
DR   STRING; 4932.YPL056C; -.
DR   PaxDb; Q02786; -.
DR   EnsemblFungi; YPL056C_mRNA; YPL056C; YPL056C.
DR   GeneID; 856051; -.
DR   KEGG; sce:YPL056C; -.
DR   SGD; S000005977; LCL1.
DR   VEuPathDB; FungiDB:YPL056C; -.
DR   HOGENOM; CLU_2293908_0_0_1; -.
DR   BioCyc; YEAST:G3O-33968-MON; -.
DR   PRO; PR:Q02786; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q02786; protein.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..81
FT                   /note="Long chronological lifespan protein 1"
FT                   /id="PRO_0000238639"
FT   PROPEP          82..101
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000238640"
FT   LIPID           81
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11332 MW;  895DAA66C25630AD CRC64;
     MKNAALCEAL PLLATCSHEI PPTPHTVCFV FPPALLLSPS KLTLLNSRRV ASRCVIIIDP
     RLLRLFSCSR PQQLPRDKNQ SFAKPSFSFF FFLLTSLLSP F