LCL2_CANTT
ID LCL2_CANTT Reviewed; 135 AA.
AC C5M3K2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Long chronological lifespan protein 2;
DE Flags: Precursor;
GN Name=LCL2; ORFNames=CTRG_00641;
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC degradation (ERAD) pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
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DR EMBL; GG692395; EER35902.1; -; Genomic_DNA.
DR RefSeq; XP_002545860.1; XM_002545814.1.
DR AlphaFoldDB; C5M3K2; -.
DR SMR; C5M3K2; -.
DR STRING; 5482.XP_002545860.1; -.
DR EnsemblFungi; EER35902; EER35902; CTRG_00641.
DR GeneID; 8296868; -.
DR KEGG; ctp:CTRG_00641; -.
DR VEuPathDB; FungiDB:CTRG_00641; -.
DR eggNOG; ENOG502S416; Eukaryota.
DR HOGENOM; CLU_142363_1_0_1; -.
DR OrthoDB; 1618788at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR InterPro; IPR034543; LCL2.
DR PANTHER; PTHR38425; PTHR38425; 1.
PE 3: Inferred from homology;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..135
FT /note="Long chronological lifespan protein 2"
FT /id="PRO_0000408602"
SQ SEQUENCE 135 AA; 15257 MW; 0BB1B2FFBCB58A53 CRC64;
MQYLLVALSL FISLSSANLF DFLNNFNHGG GGRQQQQGAR NPQEYENRIL NSQCDQYLCP
DTGLCVESPK FCPCPYPSSQ IRCFLPDGRF VCISKPAGEG ISDKYNDPKT NWKIDAKDDN
IRDCGWVNRA WRGLV