LCL2_CLAL4
ID LCL2_CLAL4 Reviewed; 126 AA.
AC C4YAT5;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Long chronological lifespan protein 2;
DE Flags: Precursor;
GN Name=LCL2; ORFNames=CLUG_05400;
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC degradation (ERAD) pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
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DR EMBL; CH408082; EEQ41272.1; -; Genomic_DNA.
DR RefSeq; XP_002614622.1; XM_002614576.1.
DR AlphaFoldDB; C4YAT5; -.
DR STRING; 306902.C4YAT5; -.
DR EnsemblFungi; EEQ41272; EEQ41272; CLUG_05400.
DR GeneID; 8495311; -.
DR KEGG; clu:CLUG_05400; -.
DR VEuPathDB; FungiDB:CLUG_05400; -.
DR HOGENOM; CLU_142363_1_0_1; -.
DR InParanoid; C4YAT5; -.
DR OMA; KPATHDE; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR InterPro; IPR034543; LCL2.
DR PANTHER; PTHR38425; PTHR38425; 1.
PE 3: Inferred from homology;
KW Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..126
FT /note="Long chronological lifespan protein 2"
FT /id="PRO_0000408603"
SQ SEQUENCE 126 AA; 14510 MW; E8FDAE0CC96EE8B9 CRC64;
MFRILYLFVL CGAVSASIFN FMHDQYQHQE PRHEVSFEQR VLESNCDKYL CPGTLECVAR
PQDCPCPYPS SQMRCVLPNG DPLCISKPTG DYNGKYDDPA KNWKVDAKDD NVRDCGWVKR
AWEGRV