ID   LCL2_KLULA              Reviewed;         134 AA.
AC   Q6CJB8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Long chronological lifespan protein 2;
DE   Flags: Precursor;
GN   Name=LCL2; OrderedLocusNames=KLLA0F19844g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC       degradation (ERAD) pathway. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98679.1; -; Genomic_DNA.
DR   RefSeq; XP_455971.1; XM_455971.1.
DR   AlphaFoldDB; Q6CJB8; -.
DR   STRING; 28985.XP_455971.1; -.
DR   EnsemblFungi; CAG98679; CAG98679; KLLA0_F19844g.
DR   GeneID; 2895506; -.
DR   KEGG; kla:KLLA0_F19844g; -.
DR   eggNOG; ENOG502S416; Eukaryota.
DR   HOGENOM; CLU_142363_1_0_1; -.
DR   InParanoid; Q6CJB8; -.
DR   OMA; KPATHDE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   InterPro; IPR034543; LCL2.
DR   PANTHER; PTHR38425; PTHR38425; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..134
FT                   /note="Long chronological lifespan protein 2"
FT                   /id="PRO_0000408608"
SQ   SEQUENCE   134 AA;  15135 MW;  A7CF1071BB64EC5D CRC64;
     MKLLGTIIGS AFFLQAVSGF FFDSGHQNRQ QQQQQQQQRD VGSYQQMFLD NDCPHYLCPQ
     TLDCVRQKSD CACPFPNSQL KCNLPNGQVI CISKPATHDP TLVEIYDDPV MGPAQRTEGF
     RDCGWILDVY DGKI