LCL2_LACTC
ID LCL2_LACTC Reviewed; 127 AA.
AC C5DMZ6;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Long chronological lifespan protein 2;
DE Flags: Precursor;
GN Name=LCL2; OrderedLocusNames=KLTH0G12958g;
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC degradation (ERAD) pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU928171; CAR25157.1; -; Genomic_DNA.
DR RefSeq; XP_002555594.1; XM_002555548.1.
DR AlphaFoldDB; C5DMZ6; -.
DR STRING; 559295.C5DMZ6; -.
DR EnsemblFungi; CAR25157; CAR25157; KLTH0G12958g.
DR GeneID; 8293877; -.
DR KEGG; lth:KLTH0G12958g; -.
DR eggNOG; ENOG502S416; Eukaryota.
DR HOGENOM; CLU_142363_1_0_1; -.
DR InParanoid; C5DMZ6; -.
DR OMA; KPATHDE; -.
DR OrthoDB; 1618788at2759; -.
DR Proteomes; UP000002036; Chromosome G.
DR InterPro; IPR034543; LCL2.
DR PANTHER; PTHR38425; PTHR38425; 1.
PE 3: Inferred from homology;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..127
FT /note="Long chronological lifespan protein 2"
FT /id="PRO_0000408609"
SQ SEQUENCE 127 AA; 14178 MW; 9656FCF8F800D5DA CRC64;
MRGSSLGLYF ILPIASGFFF DFNQRNQHEG QQPQVSYEDK VLNNDCADFL CPDTLTCVKT
AKDCPCPFPK SQLRCTLPNG QFVCISKPAT HDKNLNAIYD DPVKGPQSKI KGLRDCGWVQ
DAYKGIV