ID   LCL2_PICGU              Reviewed;         127 AA.
AC   A5DP59;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Long chronological lifespan protein 2;
DE   Flags: Precursor;
GN   Name=LCL2; ORFNames=PGUG_05060;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC       degradation (ERAD) pathway. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
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DR   EMBL; CH408160; EDK40962.1; -; Genomic_DNA.
DR   RefSeq; XP_001483105.1; XM_001483055.1.
DR   AlphaFoldDB; A5DP59; -.
DR   STRING; 4929.XP_001483105.1; -.
DR   EnsemblFungi; EDK40962; EDK40962; PGUG_05060.
DR   GeneID; 5125055; -.
DR   KEGG; pgu:PGUG_05060; -.
DR   VEuPathDB; FungiDB:PGUG_05060; -.
DR   eggNOG; ENOG502S416; Eukaryota.
DR   HOGENOM; CLU_142363_1_0_1; -.
DR   InParanoid; A5DP59; -.
DR   OMA; KPATHDE; -.
DR   OrthoDB; 1618788at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   InterPro; IPR034543; LCL2.
DR   PANTHER; PTHR38425; PTHR38425; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..127
FT                   /note="Long chronological lifespan protein 2"
FT                   /id="PRO_0000408621"
SQ   SEQUENCE   127 AA;  14122 MW;  B8ECE68C17C2EF24 CRC64;
     MHLIYFLFLV VGCSASLFDF IQNQFGGGGQ AQKSPEHYEA QVLNSNCDKY LCPGTSLCVD
     APKFCPCPYP SSQLRCFLPD GRYLCISKPA GDVAANYDDP RTNWKVDAKD DNIRDCGWVS
     RAWKGVV