ID   LCL2_YEAST              Reviewed;         131 AA.
AC   Q08045; D6VYA4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Long chronological lifespan protein 2;
DE   Flags: Precursor;
GN   Name=LCL2; OrderedLocusNames=YLR104W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=19325107; DOI=10.1126/science.1167983;
RA   Jonikas M.C., Collins S.R., Denic V., Oh E., Quan E.M., Schmid V.,
RA   Weibezahn J., Schwappach B., Walter P., Weissman J.S., Schuldiner M.;
RT   "Comprehensive characterization of genes required for protein folding in
RT   the endoplasmic reticulum.";
RL   Science 323:1693-1697(2009).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=20421943; DOI=10.1371/journal.pgen.1000921;
RA   Matecic M., Smith D.L., Pan X., Maqani N., Bekiranov S., Boeke J.D.,
RA   Smith J.S.;
RT   "A microarray-based genetic screen for yeast chronological aging factors.";
RL   PLoS Genet. 6:E1000921-E1000921(2010).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Probable component of the endoplasmic reticulum-associated
CC       degradation (ERAD) pathway that acts upstream of HRD3 and USA1.
CC       {ECO:0000269|PubMed:19325107}.
CC   -!- DISRUPTION PHENOTYPE: Leads to long chronological lifespan.
CC       {ECO:0000269|PubMed:20421943}.
CC   -!- MISCELLANEOUS: Present with 1990 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the LCL2 family. {ECO:0000305}.
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DR   EMBL; U53876; AAB67552.1; -; Genomic_DNA.
DR   EMBL; Z73276; CAA97669.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09420.1; -; Genomic_DNA.
DR   PIR; S64940; S64940.
DR   RefSeq; NP_013205.1; NM_001181991.1.
DR   AlphaFoldDB; Q08045; -.
DR   BioGRID; 31377; 60.
DR   DIP; DIP-4745N; -.
DR   STRING; 4932.YLR104W; -.
DR   MaxQB; Q08045; -.
DR   PaxDb; Q08045; -.
DR   PRIDE; Q08045; -.
DR   EnsemblFungi; YLR104W_mRNA; YLR104W; YLR104W.
DR   GeneID; 850794; -.
DR   KEGG; sce:YLR104W; -.
DR   SGD; S000004094; LCL2.
DR   VEuPathDB; FungiDB:YLR104W; -.
DR   eggNOG; ENOG502S416; Eukaryota.
DR   HOGENOM; CLU_142363_1_0_1; -.
DR   InParanoid; Q08045; -.
DR   OMA; KPATHDE; -.
DR   BioCyc; YEAST:G3O-32252-MON; -.
DR   PRO; PR:Q08045; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q08045; protein.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; HGI:SGD.
DR   InterPro; IPR034543; LCL2.
DR   PANTHER; PTHR38425; PTHR38425; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..131
FT                   /note="Long chronological lifespan protein 2"
FT                   /id="PRO_0000247350"
SQ   SEQUENCE   131 AA;  14922 MW;  1DC418D21CB9B554 CRC64;
     MSQSRWSIVL IFALFIFGST GVNAFFNFGH HQQQQQQQQQ SYEDQVLNNP CDGYLCPDTL
     TCVAQQKDCP CPFPKSQLKC VLPDNKFVCI SKPATHNEKF RAIYDDPVKG PKAKNKGFRD
     CGWVSDAYKN H