LCL3_CANTT
ID LCL3_CANTT Reviewed; 235 AA.
AC C5MC60;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Probable endonuclease LCL3;
DE EC=3.1.-.-;
GN Name=LCL3; ORFNames=CTRG_03652;
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR EMBL; GG692398; EER33227.1; -; Genomic_DNA.
DR RefSeq; XP_002549355.1; XM_002549309.1.
DR AlphaFoldDB; C5MC60; -.
DR SMR; C5MC60; -.
DR STRING; 5482.XP_002549355.1; -.
DR EnsemblFungi; EER33227; EER33227; CTRG_03652.
DR GeneID; 8297786; -.
DR KEGG; ctp:CTRG_03652; -.
DR VEuPathDB; FungiDB:CTRG_03652; -.
DR eggNOG; ENOG502S1U4; Eukaryota.
DR HOGENOM; CLU_046484_0_1_1; -.
DR OrthoDB; 1333771at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR Pfam; PF00565; SNase; 1.
DR SMART; SM00318; SNc; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50830; TNASE_3; 1.
PE 3: Inferred from homology;
KW Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW Nuclease; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Probable endonuclease LCL3"
FT /id="PRO_0000408654"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 59..217
FT /note="TNase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 156
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT BINDING 113
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ SEQUENCE 235 AA; 27012 MW; 917682B36C5CB8A3 CRC64;
MAPIPPTPAQ DISILHPKVL LLSAGITTSL FLGYRFYTRY VRRVRTYLDL TPSIIENNKK
LYGYVTRVGD GDNFRFYHTP GGLLMGWGWL RKIPTTRKEL KDETLMIRLC GIDAPEGAHF
GKPAQPFADD ALNWLRGYVD GKYVTITPYS IDQYKRVVAR AQIWKWTGKK DVSAEMLKTG
YAIVYEGKAE AEFGDNEDWY RKLEAHSKRL RKGVWSLGKK LTTPGEFKRV HYRGE
