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LCL3_KLUDE
ID   LCL3_KLUDE              Reviewed;         258 AA.
AC   Q874L8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Probable endonuclease LCL3;
DE            EC=3.1.-.-;
GN   Name=LCL3;
OS   Kluyveromyces delphensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=51657;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 2170;
RX   PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA   Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT   "Evidence from comparative genomics for a complete sexual cycle in the
RT   'asexual' pathogenic yeast Candida glabrata.";
RL   Genome Biol. 4:R10.1-R10.9(2003).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR   EMBL; AY181250; AAO25614.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q874L8; -.
DR   PhylomeDB; Q874L8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   Pfam; PF00565; SNase; 1.
DR   SMART; SM00318; SNc; 1.
DR   SUPFAM; SSF50199; SSF50199; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   3: Inferred from homology;
KW   Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW   Nuclease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..258
FT                   /note="Probable endonuclease LCL3"
FT                   /id="PRO_0000408661"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          55..245
FT                   /note="TNase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   ACT_SITE        136
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   ACT_SITE        184
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   BINDING         141
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ   SEQUENCE   258 AA;  30057 MW;  247DFE2B4562AEEA CRC64;
     MMSKDKNRTN DVLIEAGLLS LVLTGTTLAT YRGYTRYLRQ IRNARGIPSK VFRKRWLYGK
     VTAVGDGDNF HFFHMPGGLF GGWGWLRSTP QLEKIDIVKK SRNSKRLLDF FRSSNKYVDL
     PVQYKNKRRL PTISVRICGV DAPERSHFGN PAQPYSEEAL IWLQHEILGK KLWIKPLNID
     QYGRCVASIR YWTRFGYKDL SLQMLKEGLA LVYEGKSNAE FGGREKIYRR HEFIAKSKRI
     GMWSQKKLET PGDYKRKL
 
 
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