LCL3_KLUDE
ID LCL3_KLUDE Reviewed; 258 AA.
AC Q874L8;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Probable endonuclease LCL3;
DE EC=3.1.-.-;
GN Name=LCL3;
OS Kluyveromyces delphensis (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=51657;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CBS 2170;
RX PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT "Evidence from comparative genomics for a complete sexual cycle in the
RT 'asexual' pathogenic yeast Candida glabrata.";
RL Genome Biol. 4:R10.1-R10.9(2003).
CC -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR EMBL; AY181250; AAO25614.1; -; Genomic_DNA.
DR AlphaFoldDB; Q874L8; -.
DR PhylomeDB; Q874L8; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR Pfam; PF00565; SNase; 1.
DR SMART; SM00318; SNc; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50830; TNASE_3; 1.
PE 3: Inferred from homology;
KW Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW Nuclease; Transmembrane; Transmembrane helix.
FT CHAIN 1..258
FT /note="Probable endonuclease LCL3"
FT /id="PRO_0000408661"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 55..245
FT /note="TNase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 136
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 144
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT BINDING 141
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ SEQUENCE 258 AA; 30057 MW; 247DFE2B4562AEEA CRC64;
MMSKDKNRTN DVLIEAGLLS LVLTGTTLAT YRGYTRYLRQ IRNARGIPSK VFRKRWLYGK
VTAVGDGDNF HFFHMPGGLF GGWGWLRSTP QLEKIDIVKK SRNSKRLLDF FRSSNKYVDL
PVQYKNKRRL PTISVRICGV DAPERSHFGN PAQPYSEEAL IWLQHEILGK KLWIKPLNID
QYGRCVASIR YWTRFGYKDL SLQMLKEGLA LVYEGKSNAE FGGREKIYRR HEFIAKSKRI
GMWSQKKLET PGDYKRKL