ID   LCL3_PHANO              Reviewed;         296 AA.
AC   Q0UVH1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Probable endonuclease LCL3;
DE            EC=3.1.-.-;
GN   Name=LCL3; ORFNames=SNOG_04243;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR   EMBL; CH445330; EAT88003.2; -; Genomic_DNA.
DR   RefSeq; XP_001794663.1; XM_001794611.1.
DR   AlphaFoldDB; Q0UVH1; -.
DR   SMR; Q0UVH1; -.
DR   STRING; 321614.Q0UVH1; -.
DR   EnsemblFungi; SNOT_04243; SNOT_04243; SNOG_04243.
DR   GeneID; 5971531; -.
DR   KEGG; pno:SNOG_04243; -.
DR   eggNOG; ENOG502RZZQ; Eukaryota.
DR   HOGENOM; CLU_046484_0_1_1; -.
DR   InParanoid; Q0UVH1; -.
DR   OrthoDB; 1333771at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   Pfam; PF00565; SNase; 1.
DR   SMART; SM00318; SNc; 1.
DR   SUPFAM; SSF50199; SSF50199; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   3: Inferred from homology;
KW   Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW   Nuclease; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..296
FT                   /note="Probable endonuclease LCL3"
FT                   /id="PRO_0000408675"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          77..262
FT                   /note="TNase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   REGION          270..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..296
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   ACT_SITE        161
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   ACT_SITE        201
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   BINDING         158
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ   SEQUENCE   296 AA;  33679 MW;  C33BAAF7C626067C CRC64;
     MRWFGSGDDE KKKKQVGETW ADSLRADSWG QSLTNPRTLI PTFAFTITTV TALRLYKTFL
     RRIPTVNHVK PHYFRRKGIF GKVTTVGDAD NFRLYHTPGG RIAGWGWLPW KMVPTKREGL
     SNQTVGLPCH LGLLSIVSDS PSLVANNFQL HIRLAGVDAP ELAHWGREEQ PYAKEAQEWL
     INLIHNRRVR AYIYRRDQYD RIVAQVYVRR WLFRKDVGLE MLKAGLATIY EAKSGAEFGT
     SEAKYRAAEE KAKAQKVGMW AKPTLLQKLG GASTKAPESP REYKARHAAA DKLKKT