LCL3_SCHCM
ID LCL3_SCHCM Reviewed; 292 AA.
AC D8QGA7;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 41.
DE RecName: Full=Probable endonuclease LCL3;
DE EC=3.1.-.-;
GN Name=LCL3; ORFNames=SCHCODRAFT_70433;
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210;
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR EMBL; GL377311; EFI93263.1; -; Genomic_DNA.
DR RefSeq; XP_003028166.1; XM_003028120.1.
DR AlphaFoldDB; D8QGA7; -.
DR SMR; D8QGA7; -.
DR STRING; 578458.D8QGA7; -.
DR EnsemblFungi; EFI93263; EFI93263; SCHCODRAFT_70433.
DR GeneID; 9591937; -.
DR KEGG; scm:SCHCODRAFT_70433; -.
DR eggNOG; ENOG502S1U4; Eukaryota.
DR HOGENOM; CLU_046484_0_1_1; -.
DR InParanoid; D8QGA7; -.
DR OMA; IYHTPGG; -.
DR OrthoDB; 1333771at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR Pfam; PF00565; SNase; 1.
DR SMART; SM00318; SNc; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50830; TNASE_3; 1.
PE 3: Inferred from homology;
KW Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW Nuclease; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..292
FT /note="Probable endonuclease LCL3"
FT /id="PRO_0000408681"
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 83..247
FT /note="TNase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT REGION 256..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT BINDING 137
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ SEQUENCE 292 AA; 33355 MW; C1C52D8FAD5C03EE CRC64;
MPLIPWPASA DDSSKGKDDE KDIATKAKEL FALAGEIPPE YFSVAAFAAG SLSLAASYFV
HKRYFRRIPN AEWVSPNHLA RKRWIKGRVT SVGDNDNFRF YHTPGIGWRW PLKFRRVPTL
TKELKDQTIH VRIAGVDAPE NAHFGRPAQP YAQEALAYLR ARILGKTVFC QLIRRDQYGR
MVSHVRLAPR FLPATLFRGP NLAEDMLRKG WATTYEQHGA EYGEGGVERY KQIEQEAKDA
RRGIWAKGVR GETPAEYKRR YAQAADGGEP PSKARAEKEQ KRGWLQRLFS WK
