LCL3_SCHPO
ID LCL3_SCHPO Reviewed; 230 AA.
AC O60168;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable endonuclease C19F8.04c;
DE EC=3.1.-.-;
GN ORFNames=SPBC19F8.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA19124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA19124.1; -; Genomic_DNA.
DR PIR; T39827; T39827.
DR RefSeq; NP_596346.1; NM_001022266.2.
DR AlphaFoldDB; O60168; -.
DR SMR; O60168; -.
DR BioGRID; 277083; 5.
DR STRING; 4896.SPBC19F8.04c.1; -.
DR MaxQB; O60168; -.
DR PaxDb; O60168; -.
DR EnsemblFungi; SPBC19F8.04c.1; SPBC19F8.04c.1:pep; SPBC19F8.04c.
DR GeneID; 2540556; -.
DR KEGG; spo:SPBC19F8.04c; -.
DR PomBase; SPBC19F8.04c; -.
DR VEuPathDB; FungiDB:SPBC19F8.04c; -.
DR eggNOG; ENOG502S1U4; Eukaryota.
DR HOGENOM; CLU_046484_0_1_1; -.
DR InParanoid; O60168; -.
DR OMA; LLGWHWL; -.
DR PhylomeDB; O60168; -.
DR PRO; PR:O60168; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; ISM:PomBase.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR Pfam; PF00565; SNase; 1.
DR SMART; SM00318; SNc; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50830; TNASE_3; 1.
PE 3: Inferred from homology;
KW Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW Nuclease; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..230
FT /note="Probable endonuclease C19F8.04c"
FT /id="PRO_0000312663"
FT TRANSMEM 10..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 55..216
FT /note="TNase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 104
FT /evidence="ECO:0000250|UniProtKB:P00644,
FT ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 112
FT /evidence="ECO:0000250|UniProtKB:P00644,
FT ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 152
FT /evidence="ECO:0000250|UniProtKB:P00644,
FT ECO:0000255|PROSITE-ProRule:PRU00272"
FT BINDING 109
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250|UniProtKB:P00644,
FT ECO:0000255|PROSITE-ProRule:PRU00272"
SQ SEQUENCE 230 AA; 26393 MW; 49178080AEBDB3E6 CRC64;
MQESQYKEKA IIGTGLITTS IGGFFFLRRF RRISNASTIP KNYLNNSTVE NRKYKTMFGY
VTRVGDGDNF RFYHTPGGRL LGWHWLRKVP CSRSDLSNET ISVRLAGIDA PESAHFGKQE
QPYALEAKEF LHNKLYHKSV RIIPLKIDRY ARLVAGVQYY PIPHFFWKKD IGPQMIRKGL
AVVYEGSDGV FCPTKKECLL ALEIVAKKKK LSLWSQGKKL ILPSVYKRGV
