LCL3_UNCRE
ID LCL3_UNCRE Reviewed; 303 AA.
AC C4JVW2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Probable endonuclease LCL3;
DE EC=3.1.-.-;
GN Name=LCL3; ORFNames=UREG_06704;
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
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DR EMBL; CH476618; EEP81839.1; -; Genomic_DNA.
DR RefSeq; XP_002583737.1; XM_002583691.1.
DR AlphaFoldDB; C4JVW2; -.
DR SMR; C4JVW2; -.
DR STRING; 336963.C4JVW2; -.
DR EnsemblFungi; EEP81839; EEP81839; UREG_06704.
DR GeneID; 8444111; -.
DR KEGG; ure:UREG_06704; -.
DR VEuPathDB; FungiDB:UREG_06704; -.
DR eggNOG; ENOG502S1U4; Eukaryota.
DR HOGENOM; CLU_046484_0_1_1; -.
DR InParanoid; C4JVW2; -.
DR OrthoDB; 1333771at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.90; -; 1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR Pfam; PF00565; SNase; 1.
DR SMART; SM00318; SNc; 1.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50830; TNASE_3; 1.
PE 3: Inferred from homology;
KW Calcium; Endonuclease; Hydrolase; Membrane; Metal-binding; Mitochondrion;
KW Nuclease; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..303
FT /note="Probable endonuclease LCL3"
FT /id="PRO_0000408684"
FT TRANSMEM 77..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 115..276
FT /note="TNase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT ACT_SITE 212
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT BINDING 169
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
SQ SEQUENCE 303 AA; 34990 MW; 06AE5146EC9403C9 CRC64;
MRWLFWASPP QNDSHDASPN AHPRPIKPQR REAHQDHTPA PGQAAPEPTI SNAQSSRDWN
SSLNATDWKQ FTEPKTIIPT ALLTGGILLC VHIHRKYLRR IPEAGYISPS YFRRRSLLGK
VTSVGDGDNF RLYHTPGGRL GGWEWLRKVP TGKNELRNRT IHIRLAGIDA PELPHFGRPA
QPYSHEAHTW LTNYLLNRRV RAFLYRPDQY GRVVATVYVR RWLLFKQDVG LQMLKQGWAT
VYEAKTGVEF GGAELERKYR DAEAWAKRRG LGLWEGLKGK KKEKWESPRE FKTRMAAEEA
QRK
