LCLT1_CHICK
ID LCLT1_CHICK Reviewed; 378 AA.
AC Q5F3X0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Lysocardiolipin acyltransferase 1;
DE EC=2.3.1.- {ECO:0000250|UniProtKB:Q3UN02};
DE AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 8 {ECO:0000250|UniProtKB:Q6UWP7};
DE Short=1-AGP acyltransferase 8;
DE Short=1-AGPAT 8;
DE EC=2.3.1.51 {ECO:0000250|UniProtKB:Q6UWP7};
DE AltName: Full=Acyl-CoA:lysocardiolipin acyltransferase 1 {ECO:0000250|UniProtKB:Q3UN02};
GN Name=LCLAT1; Synonyms=AGPAT8 {ECO:0000250|UniProtKB:Q6UWP7}, LYCAT;
GN ORFNames=RCJMB04_5b22;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT)
CC activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin
CC (CL), a key step in CL remodeling (By similarity). Recognizes both
CC monolysocardiolipin and dilysocardiolipin as substrates with a
CC preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By
CC similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate
CC acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-
CC 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-
CC glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an
CC acyl moiety at the sn-2 position of the glycerol backbone (By
CC similarity). Possesses both lysophosphatidylinositol acyltransferase
CC (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities
CC (By similarity). Required for establishment of the hematopoietic and
CC endothelial lineages (By similarity). {ECO:0000250|UniProtKB:Q3UN02,
CC ECO:0000250|UniProtKB:Q6UWP7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-
CC sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342,
CC ChEBI:CHEBI:58608; EC=2.3.1.51;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA
CC = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA;
CC Xref=Rhea:RHEA:33195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57880,
CC ChEBI:CHEBI:58342, ChEBI:CHEBI:64771;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33196;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA =
CC 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA;
CC Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342,
CC ChEBI:CHEBI:64716, ChEBI:CHEBI:64840;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33204;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate
CC = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA;
CC Xref=Rhea:RHEA:33187, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC ChEBI:CHEBI:57518, ChEBI:CHEBI:64839;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33188;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA;
CC Xref=Rhea:RHEA:37131, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC ChEBI:CHEBI:74544, ChEBI:CHEBI:74546;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37132;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-
CC 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-
CC glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37135, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57387, ChEBI:CHEBI:74547, ChEBI:CHEBI:74548;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37136;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-
CC glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-
CC octadecenoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37139,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:74549,
CC ChEBI:CHEBI:74550; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37140;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA
CC = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA;
CC Xref=Rhea:RHEA:37143, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:74544, ChEBI:CHEBI:74551;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37144;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA
CC = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA;
CC Xref=Rhea:RHEA:37147, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394,
CC ChEBI:CHEBI:74544, ChEBI:CHEBI:74552;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37148;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-
CC glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-
CC glycerol) + CoA; Xref=Rhea:RHEA:37619, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57387, ChEBI:CHEBI:64840, ChEBI:CHEBI:75173;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37620;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-
CC myo-inositol) + CoA; Xref=Rhea:RHEA:37623, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57387, ChEBI:CHEBI:64771, ChEBI:CHEBI:75116;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37624;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) +
CC hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + CoA; Xref=Rhea:RHEA:35871, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57379, ChEBI:CHEBI:72833, ChEBI:CHEBI:72835;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35872;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) +
CC octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-
CC phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35875,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72833,
CC ChEBI:CHEBI:72836; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35876;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-
CC (1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1D-myo-inositol) + CoA; Xref=Rhea:RHEA:35879,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72833,
CC ChEBI:CHEBI:72837; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35880;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-
CC phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-
CC octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA;
CC Xref=Rhea:RHEA:35883, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383,
CC ChEBI:CHEBI:72833, ChEBI:CHEBI:72838;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35884;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-
CC glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-
CC (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol
CC + CoA; Xref=Rhea:RHEA:35867, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368,
CC ChEBI:CHEBI:72833, ChEBI:CHEBI:72834;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35868;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) +
CC hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-
CC glycerol) + CoA; Xref=Rhea:RHEA:35851, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57379, ChEBI:CHEBI:72829, ChEBI:CHEBI:75158;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35852;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) +
CC octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-
CC phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35887,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:72839,
CC ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35888;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-
CC (1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35891,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72841,
CC ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35892;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-
CC phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-
CC sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:35895,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:72840,
CC ChEBI:CHEBI:75158; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35896;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-
CC (1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37643,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72826,
CC ChEBI:CHEBI:75161; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37644;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-
CC (1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37647,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72827,
CC ChEBI:CHEBI:72845; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37648;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-
CC phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:37651,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:72828,
CC ChEBI:CHEBI:75163; Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37652;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) +
CC dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-
CC (1D-myo-inositol) + CoA; Xref=Rhea:RHEA:37639, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57375, ChEBI:CHEBI:72833, ChEBI:CHEBI:75160;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37640;
CC Evidence={ECO:0000250|UniProtKB:Q6UWP7};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-
CC phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:37615, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC ChEBI:CHEBI:75137, ChEBI:CHEBI:75139;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37616;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-
CC phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-
CC sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-
CC phospho]-glycerol + CoA; Xref=Rhea:RHEA:37611, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57387, ChEBI:CHEBI:64743, ChEBI:CHEBI:75140;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37612;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-
CC phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-
CC sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-
CC glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37675,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:64743,
CC ChEBI:CHEBI:75205; Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37676;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-
CC phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol +
CC CoA; Xref=Rhea:RHEA:37679, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375,
CC ChEBI:CHEBI:64743, ChEBI:CHEBI:75203;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37680;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-
CC CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-
CC hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:37683,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:75137,
CC ChEBI:CHEBI:75201; Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37684;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-
CC acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA;
CC Xref=Rhea:RHEA:37427, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC ChEBI:CHEBI:57970, ChEBI:CHEBI:74917;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37428;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-
CC phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-
CC 3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:37687, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383,
CC ChEBI:CHEBI:75137, ChEBI:CHEBI:75209;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37688;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol +
CC hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:37691, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:75137, ChEBI:CHEBI:75207;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37692;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol +
CC octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:37695, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394,
CC ChEBI:CHEBI:75137, ChEBI:CHEBI:75208;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37696;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-
CC phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:38623, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386,
CC ChEBI:CHEBI:64743, ChEBI:CHEBI:75990;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38624;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-
CC CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-
CC hydroxy-sn-glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38627,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57386, ChEBI:CHEBI:75137,
CC ChEBI:CHEBI:75993; Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38628;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-
CC phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-
CC phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol +
CC CoA; Xref=Rhea:RHEA:38631, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:64743, ChEBI:CHEBI:75994;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38632;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-
CC glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-
CC [1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA;
CC Xref=Rhea:RHEA:38635, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368,
CC ChEBI:CHEBI:64743, ChEBI:CHEBI:75995;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38636;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-
CC glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-
CC glycero-3-phospho]-glycerol + CoA; Xref=Rhea:RHEA:38639,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:75137,
CC ChEBI:CHEBI:75996; Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38640;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) +
CC octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-
CC myo-inositol) + CoA; Xref=Rhea:RHEA:43960, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57394, ChEBI:CHEBI:64771, ChEBI:CHEBI:83939;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43961;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-
CC CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) +
CC CoA; Xref=Rhea:RHEA:43964, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394,
CC ChEBI:CHEBI:64872, ChEBI:CHEBI:83940;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43965;
CC Evidence={ECO:0000250|UniProtKB:Q3UN02};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q6UWP7}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The HXXXXD motif is essential for acyltransferase activity and
CC may constitute the binding site for the phosphate moiety of the
CC glycerol-3-phosphate. {ECO:0000250|UniProtKB:Q9D517}.
CC -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC acyltransferase family. {ECO:0000305}.
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DR EMBL; AJ851530; CAH65164.1; -; mRNA.
DR RefSeq; NP_001026210.1; NM_001031039.1.
DR RefSeq; XP_015133569.1; XM_015278083.1.
DR RefSeq; XP_015133570.1; XM_015278084.1.
DR RefSeq; XP_015133571.1; XM_015278085.1.
DR AlphaFoldDB; Q5F3X0; -.
DR STRING; 9031.ENSGALP00000014726; -.
DR PaxDb; Q5F3X0; -.
DR PRIDE; Q5F3X0; -.
DR Ensembl; ENSGALT00000014742; ENSGALP00000014726; ENSGALG00000009056.
DR Ensembl; ENSGALT00000059445; ENSGALP00000056083; ENSGALG00000009056.
DR GeneID; 421303; -.
DR KEGG; gga:421303; -.
DR CTD; 253558; -.
DR VEuPathDB; HostDB:geneid_421303; -.
DR eggNOG; KOG1505; Eukaryota.
DR GeneTree; ENSGT00950000182836; -.
DR HOGENOM; CLU_041844_4_0_1; -.
DR InParanoid; Q5F3X0; -.
DR OMA; YWTVFPL; -.
DR OrthoDB; 959325at2759; -.
DR PhylomeDB; Q5F3X0; -.
DR TreeFam; TF314346; -.
DR Reactome; R-GGA-1482798; Acyl chain remodeling of CL.
DR Reactome; R-GGA-1483166; Synthesis of PA.
DR UniPathway; UPA00557; UER00613.
DR PRO; PR:Q5F3X0; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000009056; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; Q5F3X0; baseline and differential.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; ISS:UniProtKB.
DR GO; GO:0016746; F:acyltransferase activity; IBA:GO_Central.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0036149; P:phosphatidylinositol acyl-chain remodeling; IBA:GO_Central.
DR InterPro; IPR032098; Acyltransf_C.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR Pfam; PF16076; Acyltransf_C; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR SMART; SM00563; PlsC; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Developmental protein; Endoplasmic reticulum;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..378
FT /note="Lysocardiolipin acyltransferase 1"
FT /id="PRO_0000291579"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 85..90
FT /note="HXXXXD motif"
FT /evidence="ECO:0000250|UniProtKB:Q9D517"
SQ SEQUENCE 378 AA; 44448 MW; 655199AD448BF7D0 CRC64;
MVSWKGIYFV VALFLGSFFG SIFMLGPFLP LMFISPAWYR WITDRIVATW LTLPVALLEM
VFGAKVVVTG DGFIPGERSV IIMNHRTRMD WMFLWNCLLR YSYLRLEKIC LKSSLKSIPG
FGWAMQVAAF IFIQRKWEDD KSHFENMLHY FCDIHEPLQL LIFPEGTDLT ANTKARSNDF
AEKNGLRKYE YVLHPRTTGF TFVVECLREG NNLDAIHDIT VAYPQNIPQT EKHLLNGNFP
KEIHFHVQRY PIETVPTSKE ELQLWCQKRW EEKEERLRRF YEGGKCFDET GQSIIPPCKS
ELRVLAVKCI SLLYWTVFPM GTFALLYLYS FARWYFAAMI IIFVAQQKIF GGLELIELAC
HQYFKKQQKH DDTKMKKK
