LCN10_HUMAN
ID LCN10_HUMAN Reviewed; 187 AA.
AC Q6JVE6; A2RUU3; B0QZ79;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Epididymal-specific lipocalin-10;
DE Flags: Precursor;
GN Name=LCN10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-170, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: May play a role in male fertility. May act as a retinoid
CC carrier protein within the epididymis.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6JVE6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6JVE6-2; Sequence=VSP_040220;
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AY301271; AAQ81976.1; -; mRNA.
DR EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133045; AAI33046.1; -; mRNA.
DR CCDS; CCDS35182.2; -. [Q6JVE6-2]
DR RefSeq; NP_001001712.2; NM_001001712.2. [Q6JVE6-2]
DR AlphaFoldDB; Q6JVE6; -.
DR SMR; Q6JVE6; -.
DR GlyGen; Q6JVE6; 1 site.
DR iPTMnet; Q6JVE6; -.
DR BioMuta; LCN10; -.
DR DMDM; 62286922; -.
DR PeptideAtlas; Q6JVE6; -.
DR PRIDE; Q6JVE6; -.
DR Antibodypedia; 53298; 61 antibodies from 15 providers.
DR DNASU; 414332; -.
DR Ensembl; ENST00000474369.1; ENSP00000420564.1; ENSG00000187922.14. [Q6JVE6-1]
DR Ensembl; ENST00000497771.6; ENSP00000418491.1; ENSG00000187922.14. [Q6JVE6-2]
DR GeneID; 414332; -.
DR KEGG; hsa:414332; -.
DR MANE-Select; ENST00000497771.6; ENSP00000418491.1; NM_001001712.3; NP_001001712.2. [Q6JVE6-2]
DR UCSC; uc004civ.4; human. [Q6JVE6-1]
DR CTD; 414332; -.
DR GeneCards; LCN10; -.
DR HGNC; HGNC:20892; LCN10.
DR HPA; ENSG00000187922; Tissue enriched (epididymis).
DR MIM; 612904; gene.
DR neXtProt; NX_Q6JVE6; -.
DR OpenTargets; ENSG00000187922; -.
DR PharmGKB; PA134942375; -.
DR VEuPathDB; HostDB:ENSG00000187922; -.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_130468_0_0_1; -.
DR InParanoid; Q6JVE6; -.
DR OMA; LPRESHN; -.
DR OrthoDB; 1372208at2759; -.
DR PhylomeDB; Q6JVE6; -.
DR TreeFam; TF336103; -.
DR PathwayCommons; Q6JVE6; -.
DR BioGRID-ORCS; 414332; 87 hits in 1067 CRISPR screens.
DR ChiTaRS; LCN10; human.
DR GenomeRNAi; 414332; -.
DR Pharos; Q6JVE6; Tdark.
DR PRO; PR:Q6JVE6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6JVE6; protein.
DR Bgee; ENSG00000187922; Expressed in mucosa of stomach and 90 other tissues.
DR ExpressionAtlas; Q6JVE6; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..187
FT /note="Epididymal-specific lipocalin-10"
FT /id="PRO_0000017920"
FT MOD_RES 170
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..163
FT /evidence="ECO:0000250"
FT VAR_SEQ 87..109
FT /note="GQGCGRAQPRHPGTSGHLWASLS -> LKGCQSQEVILRKDGKKPVFGNACA
FT YAAGPREGQEG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040220"
SQ SEQUENCE 187 AA; 20759 MW; 32D1ED028AE333A7 CRC64;
MRQGLLVLAL VLVLVLVLAA GSQVQEWYPR ESHALNWNKF SGFWYILATA TDAQGFLPAR
DKRKLGASVV KVNKVGQLRV LLAFRRGQGC GRAQPRHPGT SGHLWASLSV KGVKAFHVLS
TDYSYGLVYL RLGRATQNYK NLLLFHRQNV SSFQSLKEFM DACDILGLSK AAVILPKDAS
RTHTILP
