LCN10_MOUSE
ID LCN10_MOUSE Reviewed; 182 AA.
AC Q810Z1;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Epididymal-specific lipocalin-10;
DE Flags: Precursor;
GN Name=Lcn10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X DBA/2; TISSUE=Epididymis;
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
CC -!- FUNCTION: May play a role in male fertility. May act as a retinoid
CC carrier protein within the epididymis.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in epididymis.
CC {ECO:0000269|PubMed:15363845}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AF435737; AAO84436.1; -; mRNA.
DR CCDS; CCDS15787.1; -.
DR RefSeq; NP_828875.1; NM_178036.4.
DR AlphaFoldDB; Q810Z1; -.
DR SMR; Q810Z1; -.
DR STRING; 10090.ENSMUSP00000059353; -.
DR GlyGen; Q810Z1; 2 sites.
DR PaxDb; Q810Z1; -.
DR PRIDE; Q810Z1; -.
DR ProteomicsDB; 286180; -.
DR Antibodypedia; 53298; 61 antibodies from 15 providers.
DR DNASU; 332578; -.
DR Ensembl; ENSMUST00000058912; ENSMUSP00000059353; ENSMUSG00000047356.
DR GeneID; 332578; -.
DR KEGG; mmu:332578; -.
DR UCSC; uc008ite.2; mouse.
DR CTD; 414332; -.
DR MGI; MGI:1925000; Lcn10.
DR VEuPathDB; HostDB:ENSMUSG00000047356; -.
DR eggNOG; ENOG502TF09; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_130468_0_0_1; -.
DR InParanoid; Q810Z1; -.
DR OMA; LPRESHN; -.
DR OrthoDB; 1372208at2759; -.
DR PhylomeDB; Q810Z1; -.
DR TreeFam; TF336103; -.
DR BioGRID-ORCS; 332578; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q810Z1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q810Z1; protein.
DR Bgee; ENSMUSG00000047356; Expressed in blastocyst and 1 other tissue.
DR ExpressionAtlas; Q810Z1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..182
FT /note="Epididymal-specific lipocalin-10"
FT /id="PRO_0000017921"
FT MOD_RES 165
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6JVE6"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..176
FT /evidence="ECO:0000250"
SQ SEQUENCE 182 AA; 20652 MW; 3038D53270073005 CRC64;
MKLEMALSIA LALAVVSWTQ EFFPKEAQTL NWSKFSGFWY IIAIATDTQG FLPARDKRKL
GASVVKVHKT GQLRVVIAFS RPRGCQSREV TLKKDRKRPV FRNTLKGVKG FHVLSTDYTY
GLVYLRLGRG GSNYKSLLLF NRQNISSFLS LREFLDTCHI LQLTKQATIL PKDDSCAHTI
LP
