ID   LCN12_HUMAN             Reviewed;         192 AA.
AC   Q6JVE5; A2AMJ7;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Epididymal-specific lipocalin-12;
DE   Flags: Precursor;
GN   Name=LCN12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA   Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA   Orgebin-Crist M.-C.;
RT   "Molecular evolution of epididymal lipocalin genes localized on mouse
RT   chromosome 2.";
RL   Gene 339:49-59(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds all-trans retinoic acid and may act as a retinoid
CC       carrier protein within the epididymis. May play a role in male
CC       fertility (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AY301272; AAQ81977.1; -; mRNA.
DR   EMBL; AL807752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471090; EAW88317.1; -; Genomic_DNA.
DR   CCDS; CCDS7018.2; -.
DR   RefSeq; NP_848631.2; NM_178536.3.
DR   AlphaFoldDB; Q6JVE5; -.
DR   SMR; Q6JVE5; -.
DR   BioGRID; 130342; 13.
DR   IntAct; Q6JVE5; 1.
DR   STRING; 9606.ENSP00000360696; -.
DR   BioMuta; LCN12; -.
DR   PaxDb; Q6JVE5; -.
DR   PRIDE; Q6JVE5; -.
DR   Antibodypedia; 18839; 68 antibodies from 13 providers.
DR   DNASU; 286256; -.
DR   Ensembl; ENST00000371633.8; ENSP00000360696.3; ENSG00000184925.12.
DR   GeneID; 286256; -.
DR   KEGG; hsa:286256; -.
DR   MANE-Select; ENST00000371633.8; ENSP00000360696.3; NM_178536.4; NP_848631.2.
DR   UCSC; uc004ckb.4; human.
DR   CTD; 286256; -.
DR   GeneCards; LCN12; -.
DR   HGNC; HGNC:28733; LCN12.
DR   HPA; ENSG00000184925; Tissue enriched (epididymis).
DR   MIM; 612905; gene.
DR   neXtProt; NX_Q6JVE5; -.
DR   OpenTargets; ENSG00000184925; -.
DR   PharmGKB; PA134959347; -.
DR   VEuPathDB; HostDB:ENSG00000184925; -.
DR   eggNOG; ENOG502S9R9; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_094061_2_1_1; -.
DR   InParanoid; Q6JVE5; -.
DR   OMA; FPDVTGW; -.
DR   PhylomeDB; Q6JVE5; -.
DR   TreeFam; TF336103; -.
DR   PathwayCommons; Q6JVE5; -.
DR   Reactome; R-HSA-804914; Transport of fatty acids.
DR   SignaLink; Q6JVE5; -.
DR   BioGRID-ORCS; 286256; 22 hits in 1069 CRISPR screens.
DR   ChiTaRS; LCN12; human.
DR   GenomeRNAi; 286256; -.
DR   Pharos; Q6JVE5; Tdark.
DR   PRO; PR:Q6JVE5; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q6JVE5; protein.
DR   Bgee; ENSG00000184925; Expressed in right uterine tube and 122 other tissues.
DR   ExpressionAtlas; Q6JVE5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001972; F:retinoic acid binding; ISS:UniProtKB.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..192
FT                   /note="Epididymal-specific lipocalin-12"
FT                   /id="PRO_0000017922"
FT   DISULFID        88..192
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   192 AA;  21500 MW;  F4681F87CCF7A230 CRC64;
     MRLLCGLWLW LSLLKVLQAQ TPTPLPLPPP MQSFQGNQFQ GEWFVLGLAG NSFRPEHRAL
     LNAFTATFEL SDDGRFEVWN AMTRGQHCDT WSYVLIPAAQ PGQFTVDHGV EPGADREETR
     VVDSDYTQFA LMLSRRHTSR LAVLRISLLG RSWLLPPGTL DQFICLGRAQ GLSDDNIVFP
     DVTGWSPQAS VC