LCN12_MOUSE
ID LCN12_MOUSE Reviewed; 193 AA.
AC Q6JVL5;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Epididymal-specific lipocalin-12;
DE Flags: Precursor;
GN Name=Lcn12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X DBA/2; TISSUE=Epididymis;
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
CC -!- FUNCTION: Binds all-trans retinoic acid and may act as a retinoid
CC carrier protein within the epididymis. May play a role in male
CC fertility (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in epididymis.
CC {ECO:0000269|PubMed:15363845}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AY299493; AAQ63836.1; -; mRNA.
DR CCDS; CCDS15776.1; -.
DR RefSeq; NP_084234.1; NM_029958.1.
DR AlphaFoldDB; Q6JVL5; -.
DR SMR; Q6JVL5; -.
DR STRING; 10090.ENSMUSP00000028312; -.
DR GlyGen; Q6JVL5; 2 sites.
DR PaxDb; Q6JVL5; -.
DR PRIDE; Q6JVL5; -.
DR ProteomicsDB; 292240; -.
DR Antibodypedia; 18839; 68 antibodies from 13 providers.
DR DNASU; 77701; -.
DR Ensembl; ENSMUST00000028312; ENSMUSP00000028312; ENSMUSG00000026943.
DR GeneID; 77701; -.
DR KEGG; mmu:77701; -.
DR UCSC; uc008ish.1; mouse.
DR CTD; 286256; -.
DR MGI; MGI:1924951; Lcn12.
DR VEuPathDB; HostDB:ENSMUSG00000026943; -.
DR eggNOG; ENOG502S9R9; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR InParanoid; Q6JVL5; -.
DR OMA; FPDVTGW; -.
DR OrthoDB; 1490074at2759; -.
DR PhylomeDB; Q6JVL5; -.
DR TreeFam; TF336103; -.
DR Reactome; R-MMU-804914; Transport of fatty acids.
DR BioGRID-ORCS; 77701; 1 hit in 78 CRISPR screens.
DR PRO; PR:Q6JVL5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6JVL5; protein.
DR Bgee; ENSMUSG00000026943; Expressed in esophagus and 12 other tissues.
DR ExpressionAtlas; Q6JVL5; baseline and differential.
DR Genevisible; Q6JVL5; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001972; F:retinoic acid binding; ISS:UniProtKB.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR003087; LCN2/LCN12.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01275; NGELATINASE.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..193
FT /note="Epididymal-specific lipocalin-12"
FT /id="PRO_0000017923"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 88..193
FT /evidence="ECO:0000250"
SQ SEQUENCE 193 AA; 22341 MW; E93C5586552702B3 CRC64;
MGPWWALWLI LTLPQILESQ ISAMSQGFPQ MTSFQSDQFQ GEWFVLGLAD NTFRREHRAL
LNFFTTLFEL KEKSQFQVTN SMTRGKHCNT WSYTLIPATK PGQFTRDNRG SGPGADRENI
QVIETDYITF ALVLSLRQTS SQNITRVSLL GRNWRLSHKT IDKFICLTRT QNLTKDNFLF
PDLSDWLPDP QVC
