LCN15_HUMAN
ID LCN15_HUMAN Reviewed; 184 AA.
AC Q6UWW0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Lipocalin-15;
DE Flags: Precursor;
GN Name=LCN15; ORFNames=UNQ2541/PRO6093;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 19-177.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the human lipocalin 15.";
RL Submitted (DEC-2012) to the PDB data bank.
CC -!- INTERACTION:
CC Q6UWW0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176085, EBI-16439278;
CC Q6UWW0; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-12176085, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AY358618; AAQ88981.1; -; mRNA.
DR EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093893; AAH93893.1; -; mRNA.
DR EMBL; BC093895; AAH93895.1; -; mRNA.
DR CCDS; CCDS7006.1; -.
DR RefSeq; NP_976222.1; NM_203347.1.
DR PDB; 2XST; X-ray; 1.63 A; A=19-177.
DR PDBsum; 2XST; -.
DR AlphaFoldDB; Q6UWW0; -.
DR SMR; Q6UWW0; -.
DR BioGRID; 133279; 14.
DR IntAct; Q6UWW0; 9.
DR STRING; 9606.ENSP00000313833; -.
DR BioMuta; LCN15; -.
DR DMDM; 74749403; -.
DR MassIVE; Q6UWW0; -.
DR PaxDb; Q6UWW0; -.
DR PeptideAtlas; Q6UWW0; -.
DR PRIDE; Q6UWW0; -.
DR ProteomicsDB; 67531; -.
DR Antibodypedia; 53301; 32 antibodies from 10 providers.
DR DNASU; 389812; -.
DR Ensembl; ENST00000316144.6; ENSP00000313833.5; ENSG00000177984.7.
DR GeneID; 389812; -.
DR KEGG; hsa:389812; -.
DR MANE-Select; ENST00000316144.6; ENSP00000313833.5; NM_203347.2; NP_976222.1.
DR UCSC; uc004cjd.3; human.
DR CTD; 389812; -.
DR GeneCards; LCN15; -.
DR HGNC; HGNC:33777; LCN15.
DR HPA; ENSG00000177984; Tissue enhanced (intestine, seminal vesicle).
DR neXtProt; NX_Q6UWW0; -.
DR OpenTargets; ENSG00000177984; -.
DR PharmGKB; PA164722091; -.
DR VEuPathDB; HostDB:ENSG00000177984; -.
DR eggNOG; ENOG502S13A; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_094061_3_1_1; -.
DR InParanoid; Q6UWW0; -.
DR OMA; VHMEFPR; -.
DR OrthoDB; 1107052at2759; -.
DR PhylomeDB; Q6UWW0; -.
DR TreeFam; TF336103; -.
DR PathwayCommons; Q6UWW0; -.
DR Reactome; R-HSA-804914; Transport of fatty acids.
DR SignaLink; Q6UWW0; -.
DR BioGRID-ORCS; 389812; 23 hits in 1066 CRISPR screens.
DR EvolutionaryTrace; Q6UWW0; -.
DR GenomeRNAi; 389812; -.
DR Pharos; Q6UWW0; Tdark.
DR PRO; PR:Q6UWW0; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6UWW0; protein.
DR Bgee; ENSG00000177984; Expressed in prefrontal cortex and 76 other tissues.
DR Genevisible; Q6UWW0; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..184
FT /note="Lipocalin-15"
FT /id="PRO_0000317518"
FT DISULFID 83..176
FT /evidence="ECO:0000250"
FT VARIANT 152
FT /note="S -> A (in dbSNP:rs2297723)"
FT /id="VAR_059453"
FT VARIANT 164
FT /note="K -> E (in dbSNP:rs2297722)"
FT /id="VAR_059454"
FT TURN 30..33
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 35..44
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 47..52
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 53..55
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 59..65
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 71..76
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 85..92
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 106..114
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 116..128
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 131..144
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 147..156
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 157..160
FT /evidence="ECO:0007829|PDB:2XST"
FT HELIX 164..166
FT /evidence="ECO:0007829|PDB:2XST"
FT STRAND 167..169
FT /evidence="ECO:0007829|PDB:2XST"
SQ SEQUENCE 184 AA; 20454 MW; CEE57C05BD0C8ED8 CRC64;
MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL GKKDHLSMST
RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR VPALGYLDVR IVDTDYSSFA
VLYIYKELEG ALSTMVQLYS RTQDVSPQAL KSFQDFYPTL GLPKDMMVML PQSDACNPES
KEAP
