ID   LCN6_HUMAN              Reviewed;         163 AA.
AC   P62502; B0QZ80; Q71SF6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Epididymal-specific lipocalin-6;
DE   AltName: Full=Lipocalin-5;
DE   Flags: Precursor;
GN   Name=LCN6; Synonyms=LCN5; ORFNames=UNQ643/PRO1273;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX   PubMed=14617364; DOI=10.1186/1477-7827-1-112;
RA   Hamil K.G., Liu Q., Sivashanmugam P., Anbalagan M., Yenugu S.,
RA   Soundararajan R., Grossman G., Rao A.J., Birse C.E., Ruben S.M.,
RA   Richardson R.T., Zhang Y.L., O'Rand M.G., Petrusz P., French F.S.,
RA   Hall S.H.;
RT   "LCN6, a novel human epididymal lipocalin.";
RL   Reprod. Biol. Endocrinol. 1:112-112(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA   Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA   Orgebin-Crist M.-C.;
RT   "Molecular evolution of epididymal lipocalin genes localized on mouse
RT   chromosome 2.";
RL   Gene 339:49-59(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in male fertility.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Located on the head and tail of
CC       spermatozoa with the highest concentration on the post-acrosomal region
CC       of the head, where it appears aggregated into large patches.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in epididymis.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AF303084; AAQ14494.1; -; mRNA.
DR   EMBL; AY301269; AAQ81974.1; -; mRNA.
DR   EMBL; AY358598; AAQ88961.1; -; mRNA.
DR   EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471090; EAW88259.1; -; Genomic_DNA.
DR   EMBL; BC062746; AAH62746.1; -; mRNA.
DR   CCDS; CCDS7005.1; -.
DR   RefSeq; NP_945184.1; NM_198946.2.
DR   AlphaFoldDB; P62502; -.
DR   SMR; P62502; -.
DR   BioGRID; 127644; 78.
DR   STRING; 9606.ENSP00000339621; -.
DR   iPTMnet; P62502; -.
DR   PhosphoSitePlus; P62502; -.
DR   BioMuta; LCN6; -.
DR   PaxDb; P62502; -.
DR   PRIDE; P62502; -.
DR   ABCD; P62502; 1 sequenced antibody.
DR   Antibodypedia; 67611; 109 antibodies from 22 providers.
DR   DNASU; 158062; -.
DR   Ensembl; ENST00000341206.9; ENSP00000339621.3; ENSG00000267206.6.
DR   GeneID; 158062; -.
DR   KEGG; hsa:158062; -.
DR   MANE-Select; ENST00000341206.9; ENSP00000339621.3; NM_198946.3; NP_945184.1.
DR   UCSC; uc004ciy.4; human.
DR   CTD; 158062; -.
DR   GeneCards; LCN6; -.
DR   HGNC; HGNC:17337; LCN6.
DR   HPA; ENSG00000267206; Tissue enriched (epididymis).
DR   MIM; 609379; gene.
DR   neXtProt; NX_P62502; -.
DR   OpenTargets; ENSG00000267206; -.
DR   PharmGKB; PA30310; -.
DR   VEuPathDB; HostDB:ENSG00000267206; -.
DR   eggNOG; ENOG502T76S; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_1622859_0_0_1; -.
DR   InParanoid; P62502; -.
DR   OMA; VMVTLTP; -.
DR   OrthoDB; 1307977at2759; -.
DR   PhylomeDB; P62502; -.
DR   TreeFam; TF353074; -.
DR   PathwayCommons; P62502; -.
DR   BioGRID-ORCS; 158062; 25 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 158062; -.
DR   Pharos; P62502; Tbio.
DR   PRO; PR:P62502; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P62502; protein.
DR   Bgee; ENSG00000267206; Expressed in apex of heart and 89 other tissues.
DR   ExpressionAtlas; P62502; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Fertilization; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..163
FT                   /note="Epididymal-specific lipocalin-6"
FT                   /id="PRO_0000017914"
SQ   SEQUENCE   163 AA;  18045 MW;  0860C3DD3EB0286C CRC64;
     MGGLLLAAFL ALVSVPRAQA VWLGRLDPEQ LLGPWYVLAV ASREKGFAME KDMKNVVGVV
     VTLTPENNLR TLSSQHGLGG CDQSVMDLIK RNSGWVFENP SIGVLELWVL ATNFRDYAII
     FTQLEFGDEP FNTVELYSLT ETASQEAMGL FTKWSRSLGF LSQ