LCN8_HUMAN
ID LCN8_HUMAN Reviewed; 175 AA.
AC Q6JVE9; A1L4A8; A6NMN9; Q5T5R4;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Epididymal-specific lipocalin-8;
DE Flags: Precursor;
GN Name=LCN8; Synonyms=LCN5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in male fertility. May act as a retinoid
CC carrier protein within the epididymis.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6JVE9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6JVE9-2; Sequence=VSP_040219;
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AY301268; AAQ81973.1; -; mRNA.
DR EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW88265.1; -; Genomic_DNA.
DR EMBL; BC130465; AAI30466.1; -; mRNA.
DR EMBL; BC132714; AAI32715.1; -; mRNA.
DR CCDS; CCDS35183.1; -. [Q6JVE9-2]
DR CCDS; CCDS87717.1; -. [Q6JVE9-1]
DR RefSeq; NP_001332863.1; NM_001345934.1. [Q6JVE9-1]
DR RefSeq; NP_848564.2; NM_178469.3. [Q6JVE9-2]
DR AlphaFoldDB; Q6JVE9; -.
DR SMR; Q6JVE9; -.
DR BioGRID; 126509; 15.
DR STRING; 9606.ENSP00000360753; -.
DR GlyGen; Q6JVE9; 2 sites.
DR iPTMnet; Q6JVE9; -.
DR PhosphoSitePlus; Q6JVE9; -.
DR BioMuta; LCN8; -.
DR DMDM; 62286816; -.
DR PaxDb; Q6JVE9; -.
DR PeptideAtlas; Q6JVE9; -.
DR PRIDE; Q6JVE9; -.
DR Antibodypedia; 32229; 111 antibodies from 20 providers.
DR DNASU; 138307; -.
DR Ensembl; ENST00000371688.8; ENSP00000360753.3; ENSG00000204001.10. [Q6JVE9-2]
DR Ensembl; ENST00000612714.1; ENSP00000482512.1; ENSG00000204001.10. [Q6JVE9-1]
DR GeneID; 138307; -.
DR KEGG; hsa:138307; -.
DR MANE-Select; ENST00000371688.8; ENSP00000360753.3; NM_178469.4; NP_848564.2. [Q6JVE9-2]
DR UCSC; uc004cjb.2; human. [Q6JVE9-1]
DR CTD; 138307; -.
DR DisGeNET; 138307; -.
DR GeneCards; LCN8; -.
DR HGNC; HGNC:27038; LCN8.
DR HPA; ENSG00000204001; Tissue enriched (epididymis).
DR MIM; 612902; gene.
DR neXtProt; NX_Q6JVE9; -.
DR OpenTargets; ENSG00000204001; -.
DR PharmGKB; PA134958919; -.
DR VEuPathDB; HostDB:ENSG00000204001; -.
DR eggNOG; ENOG502TDU8; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_107634_0_0_1; -.
DR InParanoid; Q6JVE9; -.
DR OMA; QKIAGFW; -.
DR OrthoDB; 1291941at2759; -.
DR PhylomeDB; Q6JVE9; -.
DR TreeFam; TF337931; -.
DR PathwayCommons; Q6JVE9; -.
DR BioGRID-ORCS; 138307; 30 hits in 1065 CRISPR screens.
DR GenomeRNAi; 138307; -.
DR Pharos; Q6JVE9; Tbio.
DR PRO; PR:Q6JVE9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6JVE9; protein.
DR Bgee; ENSG00000204001; Expressed in corpus epididymis and 90 other tissues.
DR ExpressionAtlas; Q6JVE9; baseline and differential.
DR Genevisible; Q6JVE9; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0009725; P:response to hormone; IEA:Ensembl.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..175
FT /note="Epididymal-specific lipocalin-8"
FT /id="PRO_0000017916"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 79..166
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..31
FT /note="MPGAAEALPTVTVTLVAGAVPPASGALTAHC -> MEELDRQK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040219"
SQ SEQUENCE 175 AA; 19080 MW; 47501262CA6BD5F8 CRC64;
MPGAAEALPT VTVTLVAGAV PPASGALTAH CIGGFWREVG VASDQSLVLT APKRVEGLFL
TLSGSNLTVK VAYNSSGSCE IEKIVGSEID STGKFAFPGH REIHVLDTDY EGYAILRVSL
MWRGRNFRVL KYFTRSLEDK DRLGFWKFRE LTADTGLYLA ARPGRCAELL KEELI
