ID   LCN8_MOUSE              Reviewed;         175 AA.
AC   Q924P3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Epididymal-specific lipocalin-8;
DE   AltName: Full=Epididymal 17 kDa lipocalin;
DE            Short=EP17;
DE            Short=mEP17;
DE   Flags: Precursor;
GN   Name=Lcn8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=129/SvJ;
RX   PubMed=11181548; DOI=10.1210/endo.142.3.8045;
RA   Lareyre J.-J., Winfrey V.P., Kasper S., Ong D.E., Matusik R.J., Olson G.E.,
RA   Orgebin-Crist M.-C.;
RT   "Gene duplication gives rise to a new 17-kilodalton lipocalin that shows
RT   epididymal region-specific expression and testicular factor(s)
RT   regulation.";
RL   Endocrinology 142:1296-1308(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in male fertility. May act as a retinoid
CC       carrier protein within the epididymis.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in epididymis.
CC       {ECO:0000269|PubMed:11181548}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF082221; AAK58105.1; -; Genomic_DNA.
DR   EMBL; BC048433; AAH48433.1; -; mRNA.
DR   CCDS; CCDS15786.1; -.
DR   RefSeq; NP_149157.1; NM_033145.1.
DR   AlphaFoldDB; Q924P3; -.
DR   SMR; Q924P3; -.
DR   STRING; 10090.ENSMUSP00000043902; -.
DR   GlyGen; Q924P3; 2 sites.
DR   PhosphoSitePlus; Q924P3; -.
DR   PaxDb; Q924P3; -.
DR   PRIDE; Q924P3; -.
DR   ProteomicsDB; 265049; -.
DR   Antibodypedia; 32229; 111 antibodies from 20 providers.
DR   DNASU; 78076; -.
DR   Ensembl; ENSMUST00000038482; ENSMUSP00000043902; ENSMUSG00000036449.
DR   GeneID; 78076; -.
DR   KEGG; mmu:78076; -.
DR   UCSC; uc008ita.1; mouse.
DR   CTD; 138307; -.
DR   MGI; MGI:2135945; Lcn8.
DR   VEuPathDB; HostDB:ENSMUSG00000036449; -.
DR   eggNOG; ENOG502TDU8; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_107634_0_0_1; -.
DR   InParanoid; Q924P3; -.
DR   OMA; QKIAGFW; -.
DR   OrthoDB; 1291941at2759; -.
DR   PhylomeDB; Q924P3; -.
DR   TreeFam; TF337931; -.
DR   BioGRID-ORCS; 78076; 1 hit in 74 CRISPR screens.
DR   PRO; PR:Q924P3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q924P3; protein.
DR   Bgee; ENSMUSG00000036449; Expressed in lumbar subsegment of spinal cord and 27 other tissues.
DR   Genevisible; Q924P3; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0009725; P:response to hormone; IDA:MGI.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..175
FT                   /note="Epididymal-specific lipocalin-8"
FT                   /id="PRO_0000017917"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        79..166
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   175 AA;  19866 MW;  898CAF3D9B2AA8A7 CRC64;
     MEARLLSNVC GFFLVFLLQA ESTRVELVPE KIAGFWKEVA VASDQKLVLK AQRRVEGLFL
     TFSGGNVTVK AVYNSSGSCV TESSLGSERD TVGEFAFPGN REIHVLDTDY ERYTILKLTL
     LWQGRNFHVL KYFTRSLENE DEPGFWLFRE MTADQGLYML ARHGRCAELL KEGLV