ID   LCN9_HUMAN              Reviewed;         176 AA.
AC   Q8WX39; C9J5F0; Q6JVE7;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 3.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Epididymal-specific lipocalin-9;
DE   AltName: Full=MUP-like lipocalin;
DE   Flags: Precursor;
GN   Name=LCN9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA   Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA   Orgebin-Crist M.-C.;
RT   "Molecular evolution of epididymal lipocalin genes localized on mouse
RT   chromosome 2.";
RL   Gene 339:49-59(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- INTERACTION:
CC       Q8WX39; Q8IV50-2: LYSMD2; NbExp=3; IntAct=EBI-19762110, EBI-19761491;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AY301270; AAQ81975.1; -; mRNA.
DR   EMBL; AL158822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001001676.1; NM_001001676.1.
DR   AlphaFoldDB; Q8WX39; -.
DR   SMR; Q8WX39; -.
DR   BioGRID; 134206; 105.
DR   IntAct; Q8WX39; 1.
DR   STRING; 9606.ENSP00000277526; -.
DR   DrugBank; DB02924; (4R)-limonene 1Alpha,2Alpha-epoxide.
DR   DrugBank; DB03087; 2-(Sec-Butyl)Thiazole.
DR   DrugBank; DB04512; 2-Isobutyl-3-methoxypyrazine.
DR   DrugBank; DB01760; 2-Methoxy-3-Isopropylpyrazine.
DR   DrugBank; DB03711; 6-Hydroxy-6-Methyl-Heptan-3-One.
DR   GlyGen; Q8WX39; 2 sites.
DR   iPTMnet; Q8WX39; -.
DR   PhosphoSitePlus; Q8WX39; -.
DR   BioMuta; LCN9; -.
DR   DMDM; 338817980; -.
DR   MassIVE; Q8WX39; -.
DR   PaxDb; Q8WX39; -.
DR   PeptideAtlas; Q8WX39; -.
DR   PRIDE; Q8WX39; -.
DR   Antibodypedia; 56511; 79 antibodies from 18 providers.
DR   DNASU; 392399; -.
DR   Ensembl; ENST00000277526.8; ENSP00000277526.4; ENSG00000148386.10.
DR   GeneID; 392399; -.
DR   CTD; 392399; -.
DR   DisGeNET; 392399; -.
DR   GeneCards; LCN9; -.
DR   HGNC; HGNC:17442; LCN9.
DR   HPA; ENSG00000148386; Not detected.
DR   MIM; 612903; gene.
DR   neXtProt; NX_Q8WX39; -.
DR   PharmGKB; PA134879860; -.
DR   VEuPathDB; HostDB:ENSG00000148386; -.
DR   eggNOG; ENOG502RTZI; Eukaryota.
DR   InParanoid; Q8WX39; -.
DR   OMA; AYEGENK; -.
DR   OrthoDB; 1232437at2759; -.
DR   PhylomeDB; Q8WX39; -.
DR   TreeFam; TF338197; -.
DR   PathwayCommons; Q8WX39; -.
DR   Reactome; R-HSA-804914; Transport of fatty acids.
DR   SignaLink; Q8WX39; -.
DR   BioGRID-ORCS; 392399; 4 hits in 1053 CRISPR screens.
DR   GenomeRNAi; 392399; -.
DR   Pharos; Q8WX39; Tdark.
DR   PRO; PR:Q8WX39; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8WX39; protein.
DR   Bgee; ENSG00000148386; Expressed in substantia nigra and 50 other tissues.
DR   ExpressionAtlas; Q8WX39; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002971; Maj_urinary.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01221; MAJORURINARY.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..176
FT                   /note="Epididymal-specific lipocalin-9"
FT                   /id="PRO_0000017918"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..161
FT                   /evidence="ECO:0000250"
FT   VARIANT         65
FT                   /note="H -> Y (in dbSNP:rs12352552)"
FT                   /id="VAR_056167"
FT   VARIANT         90
FT                   /note="C -> F (in dbSNP:rs7875283)"
FT                   /id="VAR_056168"
SQ   SEQUENCE   176 AA;  20285 MW;  F15525B66B909180 CRC64;
     MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI KENGDLRVFV
     RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS INYEGQNTVA VSETDYRLFI
     TFHLQNFRNG TETHTLALYE TCEKYGLGSQ NIIDLTNKDP CYSKHYRSPP RPPMRW