LCN9_MOUSE
ID LCN9_MOUSE Reviewed; 178 AA.
AC Q9D267; Q80ZC4;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Epididymal-specific lipocalin-9;
DE AltName: Full=MUP-like lipocalin;
DE Flags: Precursor;
GN Name=Lcn9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6 X DBA/2; TISSUE=Epididymis;
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in epididymis. Not detected in all other
CC tissues tested. {ECO:0000269|PubMed:15363845}.
CC -!- DEVELOPMENTAL STAGE: First detected after 3 weeks postnatal
CC development. {ECO:0000269|PubMed:15363845}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AF435738; AAO50215.1; -; mRNA.
DR EMBL; AK020305; BAB32064.1; -; mRNA.
DR CCDS; CCDS15792.1; -.
DR RefSeq; NP_084235.1; NM_029959.2.
DR AlphaFoldDB; Q9D267; -.
DR SMR; Q9D267; -.
DR STRING; 10090.ENSMUSP00000023978; -.
DR GlyGen; Q9D267; 3 sites.
DR PhosphoSitePlus; Q9D267; -.
DR PaxDb; Q9D267; -.
DR PRIDE; Q9D267; -.
DR ProteomicsDB; 292245; -.
DR Antibodypedia; 56511; 79 antibodies from 18 providers.
DR DNASU; 77704; -.
DR Ensembl; ENSMUST00000023978; ENSMUSP00000023978; ENSMUSG00000023210.
DR GeneID; 77704; -.
DR KEGG; mmu:77704; -.
DR UCSC; uc008itm.1; mouse.
DR CTD; 392399; -.
DR MGI; MGI:1924954; Lcn9.
DR VEuPathDB; HostDB:ENSMUSG00000023210; -.
DR eggNOG; ENOG502RTZI; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_094061_4_0_1; -.
DR InParanoid; Q9D267; -.
DR OMA; AYEGENK; -.
DR OrthoDB; 1331491at2759; -.
DR PhylomeDB; Q9D267; -.
DR TreeFam; TF338197; -.
DR Reactome; R-MMU-804914; Transport of fatty acids.
DR BioGRID-ORCS; 77704; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9D267; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D267; protein.
DR Bgee; ENSMUSG00000023210; Expressed in morula and 11 other tissues.
DR Genevisible; Q9D267; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002971; Maj_urinary.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01221; MAJORURINARY.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..178
FT /note="Epididymal-specific lipocalin-9"
FT /id="PRO_0000017919"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..176
FT /evidence="ECO:0000250"
FT CONFLICT 68
FT /note="N -> I (in Ref. 1; AAO50215)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 178 AA; 20503 MW; 400AD2D4658A93FF CRC64;
MVLLLVLGLV LSLATAQFNL HTAVRRDYNL ARISGTWYLD SIASDNMTRI EENGDLRLFI
RNIKLLNNGS LQFDFHFMLQ GECVAVTMVC EKTKNNGEFS VAYEGKNKVL LLETDYSMYI
IFYMQNIKNG TKTQVLALYG RSILLDKTHQ REFENICNLY GLDSQNIIDM TKKDFCFL
