ID   LCNA_LACLC              Reviewed;          75 AA.
AC   P0A313; Q00563;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Bacteriocin lactococcin-A;
DE            Short=LCN-A;
DE   Flags: Precursor;
GN   Name=lcnA;
OS   Lactococcus lactis subsp. cremoris (Streptococcus cremoris).
OG   Plasmid p9B4-6.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=9B4; PLASMID=p9B4-6;
RX   PubMed=1901707; DOI=10.1128/aem.57.2.492-498.1991;
RA   van Belkum M.J., Hayema B.J., Jeeninga R.E., Kok J., Venema G.;
RT   "Organization and nucleotide sequences of two lactococcal bacteriocin
RT   operons.";
RL   Appl. Environ. Microbiol. 57:492-498(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 22-75.
RC   STRAIN=LMG 2130;
RX   PubMed=1904860; DOI=10.1128/jb.173.12.3879-3887.1991;
RA   Holo H., Nilssen O., Nes I.F.;
RT   "Lactococcin A, a new bacteriocin from Lactococcus lactis subsp. cremoris:
RT   isolation and characterization of the protein and its gene.";
RL   J. Bacteriol. 173:3879-3887(1991).
CC   -!- FUNCTION: Kills Lactococci.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
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DR   EMBL; M63675; AAA25163.1; -; Genomic_DNA.
DR   PIR; A39443; A39443.
DR   RefSeq; WP_015081786.1; NZ_WJUW01000098.1.
DR   AlphaFoldDB; P0A313; -.
DR   SMR; P0A313; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR007464; Bacteriocin_IId.
DR   Pfam; PF04369; Lactococcin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Host cell membrane; Host membrane; Membrane; Plasmid; Secreted;
KW   Transmembrane; Transmembrane helix.
FT   PROPEP          1..21
FT                   /evidence="ECO:0000269|PubMed:1904860"
FT                   /id="PRO_0000002768"
FT   CHAIN           22..75
FT                   /note="Bacteriocin lactococcin-A"
FT                   /id="PRO_0000002769"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   75 AA;  8070 MW;  C328BC1313F6DB68 CRC64;
     MKNQLNFNIV SDEELSEANG GKLTFIQSTA AGDLYYNTNT HKYVYQQTQN AFGAAANTIV
     NGWMGGAAGG FGLHH