ID   LCNA_LACLL              Reviewed;          75 AA.
AC   P0A312; Q00563;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Bacteriocin lactococcin-A;
DE            Short=LCN-A;
DE   Flags: Precursor;
GN   Name=lcnA;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG   Plasmid pNP2.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Biovar diacetylactis WM4;
RX   PubMed=1622271; DOI=10.1128/aem.58.6.1952-1961.1992;
RA   Stoddard G.W., Petzel J.P., van Belkum M.J., Kok J., McKay L.L.;
RT   "Molecular analyses of the lactococcin A gene cluster from Lactococcus
RT   lactis subsp. lactis biovar diacetylactis WM4.";
RL   Appl. Environ. Microbiol. 58:1952-1961(1992).
CC   -!- FUNCTION: Kills Lactococci.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
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DR   EMBL; M90969; AAA92856.1; -; Genomic_DNA.
DR   PIR; A39443; A39443.
DR   RefSeq; WP_015081786.1; NZ_WJUM01000062.1.
DR   AlphaFoldDB; P0A312; -.
DR   SMR; P0A312; -.
DR   TCDB; 1.C.22.1.1; the lactococcin a (lactococcin a) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR007464; Bacteriocin_IId.
DR   Pfam; PF04369; Lactococcin; 1.
PE   4: Predicted;
KW   Antibiotic; Antimicrobial; Bacteriocin; Host cell membrane; Host membrane;
KW   Membrane; Plasmid; Secreted; Transmembrane; Transmembrane helix.
FT   PROPEP          1..21
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000002766"
FT   CHAIN           22..75
FT                   /note="Bacteriocin lactococcin-A"
FT                   /id="PRO_0000002767"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   75 AA;  8070 MW;  C328BC1313F6DB68 CRC64;
     MKNQLNFNIV SDEELSEANG GKLTFIQSTA AGDLYYNTNT HKYVYQQTQN AFGAAANTIV
     NGWMGGAAGG FGLHH