LCNCL_LACLA
ID LCNCL_LACLA Reviewed; 715 AA.
AC Q9CJB8;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Lactococcin transport/processing ATP-binding protein LcnC-like;
DE EC=3.4.22.-;
DE EC=7.-.-.-;
GN Name=lcnC; OrderedLocusNames=LL0079; ORFNames=L82520;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Involved in the export process of a bacteriocin lactococcin.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. HlyB family.
CC {ECO:0000305}.
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DR EMBL; AE005176; AAK04177.1; -; Genomic_DNA.
DR PIR; G86634; G86634.
DR RefSeq; NP_266235.1; NC_002662.1.
DR RefSeq; WP_010905094.1; NC_002662.1.
DR AlphaFoldDB; Q9CJB8; -.
DR SMR; Q9CJB8; -.
DR STRING; 272623.L82520; -.
DR MEROPS; C39.001; -.
DR PaxDb; Q9CJB8; -.
DR EnsemblBacteria; AAK04177; AAK04177; L82520.
DR KEGG; lla:L82520; -.
DR PATRIC; fig|272623.7.peg.88; -.
DR eggNOG; COG2274; Bacteria.
DR HOGENOM; CLU_000604_84_3_9; -.
DR OMA; QQSHFIE; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043214; F:ABC-type bacteriocin transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005897; Pept_C39_ABC_bacteriocin.
DR InterPro; IPR005074; Peptidase_C39.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF03412; Peptidase_C39; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR TIGRFAMs; TIGR01193; bacteriocin_ABC; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50990; PEPTIDASE_C39; 1.
PE 3: Inferred from homology;
KW ATP-binding; Bacteriocin transport; Cell membrane; Hydrolase; Membrane;
KW Nucleotide-binding; Protease; Protein transport; Reference proteome;
KW Thiol protease; Translocase; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..715
FT /note="Lactococcin transport/processing ATP-binding protein
FT LcnC-like"
FT /id="PRO_0000092398"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 11..138
FT /note="Peptidase C39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362"
FT DOMAIN 168..450
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 482..715
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362,
FT ECO:0000255|PROSITE-ProRule:PRU00434"
FT ACT_SITE 17
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362"
FT BINDING 515..522
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00362,
FT ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 715 AA; 79865 MW; 360EBFEDFDBD8255 CRC64;
MKFKKKNYTS QVDEMDCGCA ALSMILKSYG TEKSLASLRL LAGTTIEGTS ALGIKKAGEG
LGFVVQVLRA DASLFEMKKV PYPFIAHVIK NQKYPHYYVI TGANKNSVFI ADPDPTVKMT
KLSKEVFLSE WTGISLFLSP TPSYQPTKEK TSSLLSFIPI ITRQKKVILN IVIASFIVTL
INILGSYYLQ SMIDSYIPNA LMGTLGIISV GLLLTYIIQQ VLEFAKAFLL NVLSQRLAID
VILSYIRHIF QLPMSFFSTR RTGEITSRFS DASSILDAIA STILSLFLDL TIVLMTGLIL
GLQNMQLFLL VLLAIPLYIV VIIIFTPLFE RQNHEVMQTN AILNSSIIED INGIETIKAL
ASEQERYQKI DYEFASYLKE AFTLQQSEAI QTAIKTTVQL VLNVLILWFG ATLVMHQKIT
LGQLITFNAL LSYFTNPITN IINLQTKLQK ARVANERLNE VYLVPSEFEE KKTELSLSHF
NLNMSEISYQ YGFGRKVLSE IKLSIKENEK LTIVGISGSG KSTLVKLLVN FFQPTSGTIT
LGGIDLQQFD KHQLRRLINY LPQQPYIFTG SIMDNLLLGA SEATSQEEII RAVELAEIRA
DIEQMQLGYQ TELSSDASSL SGGQKQRIAL ARALLSPAKI LILDEATSNL DMITEKKILK
NLLALDKTII FIAHRLSVAE MSHRIIVIEQ GKVIESGSHS ELLAQNGFYA QLYHN
