ID   LCNL1_HUMAN             Reviewed;         164 AA.
AC   Q6ZST4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Lipocalin-like 1 protein;
GN   Name=LCNL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-68.
RC   TISSUE=Caudate nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; AK127160; BAC86862.1; -; mRNA.
DR   EMBL; AL807752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43908.1; -.
DR   RefSeq; NP_997393.3; NM_207510.3.
DR   AlphaFoldDB; Q6ZST4; -.
DR   SMR; Q6ZST4; -.
DR   BioGRID; 135151; 2.
DR   IntAct; Q6ZST4; 2.
DR   MINT; Q6ZST4; -.
DR   STRING; 9606.ENSP00000386162; -.
DR   iPTMnet; Q6ZST4; -.
DR   PhosphoSitePlus; Q6ZST4; -.
DR   BioMuta; LCNL1; -.
DR   DMDM; 296434562; -.
DR   PaxDb; Q6ZST4; -.
DR   PRIDE; Q6ZST4; -.
DR   Antibodypedia; 66991; 14 antibodies from 5 providers.
DR   DNASU; 401562; -.
DR   Ensembl; ENST00000408973.3; ENSP00000386162.2; ENSG00000214402.7.
DR   GeneID; 401562; -.
DR   KEGG; hsa:401562; -.
DR   MANE-Select; ENST00000408973.3; ENSP00000386162.2; NM_207510.4; NP_997393.3.
DR   UCSC; uc004ckh.2; human.
DR   CTD; 401562; -.
DR   GeneCards; LCNL1; -.
DR   HGNC; HGNC:34436; LCNL1.
DR   HPA; ENSG00000214402; Tissue enhanced (brain, choroid plexus, testis).
DR   neXtProt; NX_Q6ZST4; -.
DR   OpenTargets; ENSG00000214402; -.
DR   PharmGKB; PA164722092; -.
DR   VEuPathDB; HostDB:ENSG00000214402; -.
DR   eggNOG; ENOG502S0P6; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_1622841_0_0_1; -.
DR   InParanoid; Q6ZST4; -.
DR   OMA; AGSWCLW; -.
DR   OrthoDB; 1107052at2759; -.
DR   PhylomeDB; Q6ZST4; -.
DR   PathwayCommons; Q6ZST4; -.
DR   SignaLink; Q6ZST4; -.
DR   BioGRID-ORCS; 401562; 8 hits in 1059 CRISPR screens.
DR   ChiTaRS; LCNL1; human.
DR   GenomeRNAi; 401562; -.
DR   Pharos; Q6ZST4; Tdark.
DR   PRO; PR:Q6ZST4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q6ZST4; protein.
DR   Bgee; ENSG00000214402; Expressed in left testis and 82 other tissues.
DR   Genevisible; Q6ZST4; HS.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..164
FT                   /note="Lipocalin-like 1 protein"
FT                   /id="PRO_0000348470"
FT   VARIANT         68
FT                   /note="A -> T (in dbSNP:rs17578859)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_046189"
SQ   SEQUENCE   164 AA;  17784 MW;  E0C265A527C6A0BB CRC64;
     MVGVVSDDQD FLDSKDTMKM AVVLVTPLGN GDLALKFGYP TPHGGCQKMD TTFTEGAVPG
     QFSNPAMALS DIRVAFSDYQ HFALLYLEMR KGGLRNQWLQ LYGGRAAGRR PRHPRFGSGM
     SPLCLHQPFL HAEGGTAGSW CLWPRVPAPP CPSLPLFAPP APSL