ID   LCNM_LACLL              Reviewed;          37 AA.
AC   P83002;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2002, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Bacteriocin lactococcin MMFII;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   STRAIN=MMFII;
RX   PubMed=11728715; DOI=10.1111/j.1574-6968.2001.tb10924.x;
RA   Ferchichi M., Frere J., Mabrouk K., Manai M.;
RT   "Lactococcin MMFII, a novel class IIa bacteriocin produced by Lactococcus
RT   lactis MMFII, isolated from a Tunisian dairy product.";
RL   FEMS Microbiol. Lett. 205:49-55(2001).
RN   [2]
RP   SYNTHESIS, AND 3D-STRUCTURE MODELING.
RC   STRAIN=MMFII;
RX   PubMed=11708769; DOI=10.1006/bbrc.2001.5908;
RA   Ferchichi M., Fathallah M., Mansuelle P., Rochat H., Sabatier J.-M.,
RA   Manai M., Mabrouk K.;
RT   "Chemical synthesis, molecular modeling, and antimicrobial activity of a
RT   novel bacteriocin, MMFII.";
RL   Biochem. Biophys. Res. Commun. 289:13-18(2001).
CC   -!- FUNCTION: Bacteriocin active against Listeria monocytogenes and
CC       Lactococcus cremoris. {ECO:0000269|PubMed:11728715}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=4143.66; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11728715};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P83002; -.
DR   SMR; P83002; -.
DR   TCDB; 1.C.24.1.14; the pediocin (pediocin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023384; Bacteriocin_IIa_CS.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
DR   PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Bacteriocin lactococcin MMFII"
FT                   /id="PRO_0000044637"
FT   DISULFID        9..14
SQ   SEQUENCE   37 AA;  4145 MW;  3AC16CEAD33332C5 CRC64;
     TSYGNGVHCN KSKCWIDVSE LETYKAGTVS NPKDILW